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Team:Carnegie Mellon/Modeling
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Intracellular model
The intracellular model attempts to simulate the synthesis and action of KillerRed. It includes:
mRNA synthesis and degradation KillerRed synthesis, maturation, and degradation KillerRed states: singlet, singlet excited, triplet excited, and deactivated Superoxide production (by KillerRed) Superoxide elimination (by superoxide dismutase)
Parameters:
mRNA synthesis: adapted from Kennell and Riezman 1977.
mRNA degradation: Bernstein, Lin, Cohen, and Lin-Chao 2002.
KillerRed synthesis: from Kennell and Riezman 1977 and our own fluorescence data
Superoxide production: adapted from Tsien and Waggoner 1995; Song, Hennink, Young, and Tanke 1995; and our own fluorescence data.
