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From 2013.igem.org

E. coli Nissle 1917

E. coli Nissle 1917 is a lowly-immunogenic strain of Escherichia coli used in commercial probiotics, such as Mutaflor. The ASU iGEM team aims to port our final vaccine construct into Nissle for safe use as a vaccine delivery vector. Because Nissle has properties that make it lowly immunogenic, it serves as a stronger candidate for a vaccine vector compared to current chassis, such as Salmonella and Listeria, because it is less likely to trigger an immune response to pathogen associated molecular patterns (PAMPs) on the bacteria itself.