Team:UCL/Project/Chemotaxis

INSERTING THE CIRCUIT

Ways to get GEM into the brain

It is all very well having designed a genetic circuit to combat a disease, but unless it can be feasibly transfected into the correct cells, or unless one can easily implant the transfected cells in sufficient quantity, in the correct locales and without significant bodily damage, that circuit is practically useless. Therefore, we have considered some methods of getting our genetically engineered microglia (GEM) into the brain that could plausibly seen in future clinical practice.