Team:Ciencias-UNAM

From 2013.igem.org

Revision as of 22:55, 21 September 2013 by Nataquinones (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Home

HOME

PROJECT

HUMAN PRACTICES

TEAM

SAFETY

Overview

General Design

Wet Lab

Dry Lab

Conclusions

References

Bios

Sponsors

Overview

Journalism

Interviews

THE PROJECT

THE PEOPLE

PARTS

ACHIEVEMENTS

We designed a synthetic system in E. coli to express an antimicrobial peptide (Cathelicidin LL-37) in vivo only in the presence of a quorum sensing molecule (AI-2) and expel it with an efflux pump in order to act against targeted gastrointestinal pathogens. This is an effort to explore alternatives were some drug administration issues could be solved with Synthetic Biology.

We are the team from Facultad de Ciencias, UNAM in Mexico City. Our team brings together students and teachers from all over the country, with various backgrounds and interests.

We submitted several devices mainly to test and use the following parts: Cathelicidin LL-37: An antimicrobial peptide against bacterial infection; MarA: A peptide responsible for an efflux pump in E. coli that is related to its resistance to cathelicidin and similar peptides asRNA-LuxS: An antisense RNA we designed to inhibit the expression of LuxS, thus inhibiting the production of AI-2, as an alternative to using a LuxS(-) chassis.

Praesent libero arcu, convallis et dapibus sit amet, aliquet nec nibh. Nulla eu aliquam orci. Phasellus vitae nunc ut urna tincidunt accumsan vel ac dui. Donec tempus quis quam vitae ultrices. Vestibulum congue nec odio eget dictum. Sed tincidunt velit enim. Fusce metus augue, lobortis eget viverra sit amet, fringilla.

Read the abstract

Meet the team