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From 2013.igem.org

NRP-UEA-Norwich iGEM 2013 team. Our team is based at the School of Biological Sciences at The Univeristy of East Anglia on the Norwich Research Park

Team NRP-UEA-Norwich iGEM 2013 are developing a biosensor that will enable the identification of novel antimycin-producing strains of streptomycetes. Antibiotic resistance is a rapidly growing global problem and is being exacerbated by the failure to discover new antibiotics. Antimycins produced by streptomycetes are active against various fungi through inhibition of the final stage of electron transport, and it has also been suggested that modified antimycins could be effective anti-cancer drugs. Building up a library of antimycin gene clusters will broaden known pathway (biosynthetic) diversity with the foresight of facilitating genetic engineering. In the long term, pathways could be engineered to create new variants of antimycin with unique or enhanced properties.

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