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Http://2013.igem.org/Team:TU-Delft/LabWork/General Concepts
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General Concepts
Our project deals with E.coli cells which sense auto-inducing peptides (AIPs) from the Staphylococcus aureus and starts producing antimicrobial peptides in order to kill the Staphylococcus aureus. Autoinducing peptides are involved in inter-species communication in gram-positive bacteria. Many of these peptides are exported by dedicated systems, post translationally modified in various ways, and finally sensed by other cells via membrane-located receptors that are part of two-component regulatory systems. Autoinducing peptide-based quorum sensing systems are displayed by various gram-positive bacteria like Staphylococcus aureus .
