Team:Michigan/Modeling

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Overview Introduction Expression Model Switch Model Inducible Hbif Model Future Directions

Contents

Overview

Best model.jpg

Model of Recombinase Expression

Model of the Switch

Model of Inducible Hbif

Introduction

• switch modeling 

   • goals: produce both states of switch, use model to optimize switch

• mass action modeling 

   • what is mass action

• pros of mass action modeling, i.e. why we used it

• form of mass action models/solvability doc

• analytical modeling 

   • formulation

   • reduction

   • solution

   • equilibration

   • stabilization

   • calibration

   • optimization

File:Solvability.pdf

Expression Model

Expression.jpg
ExpressionModelFigure.png
ExpressionModel1.png
ExpressionModel2.png
ExpressionModel3.png
ExpressionModel4.png
ExpressionModel5.png

Switch Model

Switch.jpg
SwitchModelFigure.png
SwitchModel1.png
SwitchModel2.png
SwitchModel3.png
SwitchModel4-1.png
SwitchModel4-2.png
SwitchModel5-1.png
SwitchModel5-2.png

Inducible Hbif Model

InducedHbif.jpg
InducibleHbifModelFigure.png

System:

InducibleHbifModel1.png

Conservation Equation:

InducibleHbifModel2.png

Reduced System:

InducibleHbifModel3.png

Solution:

InducibleHbifModel4.png

Steady State:

InducibleHbifModel5.png

Calibration:

InducibleHbifModel6-1.png
InducibleHbifModel6-2.png

Future Directions

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