From 2013.igem.org

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  • E. coli
  • Methanococcus
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  • Engineering Seminar
  • Clarke Middle School
• Human Practice
• The Team
  • Meet The Team
  • Official Team Profile
• Acknowledgements

Human Practice

Geraniol, among other isoprenoids, have shown to inhibit the growth of pancreatic cancers. The use of geraniol as a tumor suppressor works effectively without significantly raising blood cholesterol levels.[http://http://www.ncbi.nlm.nih.gov/pubmed/9075204 (1)]

Geraniol has been shown to inhibit prostate cancer growth in mice. Efficiency of inhibition is significantly increased using geraniol in additional to the chemical docetaxel. The inhibition of prostate cancer is achieved by restoring the cells ability to experience cell cycle arrest and apoptosis. [http://http://www.ncbi.nlm.nih.gov/pubmed/21371438 (2)]

Geraniol was tested as a secondary chemical to aid in the inhibition of colonic cancer growth. Geraniol increases sensitivity of 5-fluorouracil (5-FU) treatment. The addition of geraniol in a 5-FU treatment shows double the anti-prolific effect on colonic cancer cells. [http://www.ncbi.nlm.nih.gov/pubmed/11961066 (3)]

Geraniol shows applications in cancer treatment, along with biofuels and environmental enhancement. Furthermore, our methanogen model exhibits great genetic conservation with methanogenic archaea in the human body, and thus enhancing engineering in this organism creates new opportunities for human applications.