Team:Carnegie Mellon/Modeling

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Intracellular model

The intracellular model attempts to simulate the synthesis and action of

KillerRed. It includes:

mRNA synthesis and degradation KillerRed synthesis, maturation, and degradation KillerRed states: singlet, singlet excited, triplet excited, and deactivated Superoxide production (by KillerRed) Superoxide elimination (by superoxide dismutase)

Parameters:

mRNA synthesis: adapted from Kennell and Riezman 1977. mRNA degradation: Bernstein, Lin, Cohen, and Lin-Chao 2002. KillerRed synthesis: from Kennell and Riezman 1977 and our own fluorescence data Superoxide production: adapted from Tsien and Waggoner 1995; Song, Hennink, Young, and Tanke 1995; and our own fluorescence data.

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