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From 2013.igem.org

Model 1

Overview

This model simulates the behaviour of a hemochromatosis suffering person's duodenum. We compute the quantity of iron absorbed by the organism. Our genetically modified bacterias are also released in the duodenum and produce siderophores to chelate the solved iron, thus making it unavailable for intestinal absorption.

Assumptions

• Bacterias don't settle in the duodenum
• No iron regulation
• Constant iron flow
• Homogeneous fluid
• The bacterial quantity is constant
• The bacterial natural absorption is insignificant compared to the chelation

Model Description

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Equation System

A : Total quantity of iron absorbed by the duodenum (mol)
S : Quantity of solved iron (mol)
P : Total quantity of enterobactin produced by our population of bacteria (mol)
Q : Total quantity of chelated iron (mol)
N : Number of bacteria

Results

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Conclusion

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