Regulating protein activity is important throughout lifescience research. Even though there are several systems available for regulation of proteins all suffer from certain disadvantages. Some are dependend on chemical stimuli, do not allow fast regulation, are not easily usable for many proteins or result in only a small difference in activity of the proteins.
Aiming to overcome all of these drawbacks we engineer a novel system for light dependend regulation of protein degradation resulting in a rapid change of activity. Our system can be not only of great importance for fundamental science to investigate protein function but also for bioreactors and biological machines to accurately control their activity.
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