http://2013.igem.org/wiki/index.php?title=Special:Contributions&feed=atom&limit=250&target=21Robin12&year=&month=2013.igem.org - User contributions [en]2024-03-29T07:34:14ZFrom 2013.igem.orgMediaWiki 1.16.5http://2013.igem.org/Team:UCL/static/wiki.cssTeam:UCL/static/wiki.css2013-10-05T03:57:46Z<p>21Robin12: </p>
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}</div>21Robin12http://2013.igem.org/Team:UCL/ModelingTeam:UCL/Modeling2013-10-05T03:56:22Z<p>21Robin12: </p>
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<p class="major_title">DRY LAB</p><br />
<p class="minor_title">Modelling The Treatment And Finding New Parts</p><br />
<p class="abstract_text" style="color:#404040;"><br />
Mathematical modelling provides a powerful tool for scientists of all disciplines, allowing inspection and manipulation of a system in ways which are unachievable in the lab. In the context of biology, we can use mathematical models to study the behaviour of a single cell or an entire ecosystem. In fact, inspecting a mathematical model is very much like a laboratory experiment – the main difference being that in modelling, the environment is artificial. <br><br><br />
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Click the abstracts below to read more.<br />
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<a href="https://static.igem.org/mediawiki/2013/f/f3/Twobrain.png" data-lightbox="image-1" title="UCL iGEM 2013"><br />
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<img src="https://static.igem.org/mediawiki/2013/a/aa/Modelling_pic.jpg"><br />
</a><br />
</div><br />
<br />
<div class="col_abstract"><br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Overview"><br />
<p class="abstract_title">Model Overview</p><br />
<p class="abstract_text"><br />
Mathematical modelling provides a powerful tool for scientists of all disciplines, allowing inspection and manipulation of a system in ways which are unachievable in the lab. In the context of biology, we can use mathematical models to study the behaviour of a single cell or an entire ecosystem. In fact, inspecting a mathematical model is very much like a laboratory experiment – the main difference being that in modelling, the environment is artificial. <br />
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</div><br />
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<div class="col_abstract"><br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Two"><br />
<p class="abstract_title">Simulation Results</p><br />
<p class="abstract_text"><br />
For all the complex calculations and mechanisms behind a model, it is without much worth if it cannot produce useful results. In general, 'useful results' are defined as successful predictions about the effects of modifying some parameter - if we can use a model to determine the effect of each variable upon the outcome, we can better design our system in the real world. <br />
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<img src="https://static.igem.org/mediawiki/2013/6/69/University_of_Westminster.png"><br />
</a><br />
</div><br />
<br />
<div class="col_abstract"><br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Westminster"><br />
<p class="abstract_title">Westminster collaboration</p><br />
<p class="abstract_text"><br />
Since Westminster's iGEM team had not produced a model of their own, and their project has several similarities to ours, we have constructed an additional model, also in C#, and sent this to Westminster's team for them to use. The model simulates bed bugs moving randomly in a cubic room. One of their proposed "blood traps" is integrated into the simulation, which visually demonstrates bed bugs being attracted and then subsequently killed by the device. <br />
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<a href="https://static.igem.org/mediawiki/2013/8/89/BioInformatics.gif" data-lightbox="image-1" title="Bioinformatics Co-alteration Searching Algorithm UCL iGEM 2013"><br />
<img src="https://static.igem.org/mediawiki/2013/8/89/BioInformatics.gif"><br />
</a><br />
</div><br />
<br />
<div class="col_abstract"><br />
<br />
<br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Bioinformatics"><br />
<p class="abstract_title">Bioinformatics</p><br />
<p class="abstract_text">Using bioinformatics we can identify key genes whose dysfunction drives disease states. In so doing, we are should be able to come up with new parts that target these dysfunctional genes to increase the efficacy of synthetic biological constructs. <br />
</p><br />
</a><br />
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</html></div>21Robin12http://2013.igem.org/File:University_of_Westminster.pngFile:University of Westminster.png2013-10-05T03:55:52Z<p>21Robin12: </p>
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<div></div>21Robin12http://2013.igem.org/Team:UCL/ModelingTeam:UCL/Modeling2013-10-05T03:54:50Z<p>21Robin12: </p>
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<div class="row_large"><br />
<br />
<div class="col_left"><br />
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<p class="major_title">DRY LAB</p><br />
<p class="minor_title">Modelling The Treatment And Finding New Parts</p><br />
<p class="abstract_text" style="color:#404040;"><br />
Mathematical modelling provides a powerful tool for scientists of all disciplines, allowing inspection and manipulation of a system in ways which are unachievable in the lab. In the context of biology, we can use mathematical models to study the behaviour of a single cell or an entire ecosystem. In fact, inspecting a mathematical model is very much like a laboratory experiment – the main difference being that in modelling, the environment is artificial. <br><br><br />
</p><br />
<p class="abstract_text" style="color:#C14645;"><br />
Click the abstracts below to read more.<br />
</p><br />
<br />
</div><br />
<br />
<div class="col_right"><br />
<a href="https://static.igem.org/mediawiki/2013/f/f3/Twobrain.png" data-lightbox="image-1" title="UCL iGEM 2013"><br />
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<img src="https://static.igem.org/mediawiki/2013/a/aa/Modelling_pic.jpg"><br />
</a><br />
</div><br />
<br />
<div class="col_abstract"><br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Overview"><br />
<p class="abstract_title">Model Overview</p><br />
<p class="abstract_text"><br />
Mathematical modelling provides a powerful tool for scientists of all disciplines, allowing inspection and manipulation of a system in ways which are unachievable in the lab. In the context of biology, we can use mathematical models to study the behaviour of a single cell or an entire ecosystem. In fact, inspecting a mathematical model is very much like a laboratory experiment – the main difference being that in modelling, the environment is artificial. <br />
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</div><br />
<br />
<div class="col_abstract"><br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Two"><br />
<p class="abstract_title">Simulation Results</p><br />
<p class="abstract_text"><br />
For all the complex calculations and mechanisms behind a model, it is without much worth if it cannot produce useful results. In general, 'useful results' are defined as successful predictions about the effects of modifying some parameter - if we can use a model to determine the effect of each variable upon the outcome, we can better design our system in the real world. <br />
</p><br />
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</div><br />
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<a href="https://static.igem.org/mediawiki/2013/8/89/BioInformatics.gif" data-lightbox="image-1" title="Bioinformatics Co-alteration Searching Algorithm UCL iGEM 2013"><br />
<img src="https://static.igem.org/mediawiki/2013/8/89/BioInformatics.gif"><br />
</a><br />
</div><br />
<br />
<div class="col_abstract"><br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Westminster"><br />
<p class="abstract_title">Westminster collaboration</p><br />
<p class="abstract_text"><br />
Since Westminster's iGEM team had not produced a model of their own, and their project has several similarities to ours, we have constructed an additional model, also in C#, and sent this to Westminster's team for them to use. The model simulates bed bugs moving randomly in a cubic room. One of their proposed "blood traps" is integrated into the simulation, which visually demonstrates bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
</a><br />
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<div class="gap"><br />
</div><br />
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<a href="https://static.igem.org/mediawiki/2013/8/89/BioInformatics.gif" data-lightbox="image-1" title="Bioinformatics Co-alteration Searching Algorithm UCL iGEM 2013"><br />
<img src="https://static.igem.org/mediawiki/2013/8/89/BioInformatics.gif"><br />
</a><br />
</div><br />
<br />
<div class="col_abstract"><br />
<br />
<br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Bioinformatics"><br />
<p class="abstract_title">Bioinformatics</p><br />
<p class="abstract_text">Using bioinformatics we can identify key genes whose dysfunction drives disease states. In so doing, we are should be able to come up with new parts that target these dysfunctional genes to increase the efficacy of synthetic biological constructs. <br />
</p><br />
</a><br />
</div><br />
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</div><br />
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<div class="gap"><br />
</div><br />
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</html></div>21Robin12http://2013.igem.org/Team:UCL/ModelingTeam:UCL/Modeling2013-10-05T03:54:15Z<p>21Robin12: </p>
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<p class="major_title">DRY LAB</p><br />
<p class="minor_title">Modelling The Treatment And Finding New Parts</p><br />
<p class="abstract_text" style="color:#404040;"><br />
Awaiting Input.<br><br><br />
</p><br />
<p class="abstract_text" style="color:#C14645;"><br />
Click the abstracts below to read more.<br />
</p><br />
<br />
</div><br />
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<div class="col_right"><br />
<a href="https://static.igem.org/mediawiki/2013/f/f3/Twobrain.png" data-lightbox="image-1" title="UCL iGEM 2013"><br />
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<a href="https://static.igem.org/mediawiki/2013/a/aa/Modelling_pic.jpg" data-lightbox="image-1" title="Modelling Overview UCL iGEM 2013"><br />
<img src="https://static.igem.org/mediawiki/2013/a/aa/Modelling_pic.jpg"><br />
</a><br />
</div><br />
<br />
<div class="col_abstract"><br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Overview"><br />
<p class="abstract_title">Model Overview</p><br />
<p class="abstract_text"><br />
Mathematical modelling provides a powerful tool for scientists of all disciplines, allowing inspection and manipulation of a system in ways which are unachievable in the lab. In the context of biology, we can use mathematical models to study the behaviour of a single cell or an entire ecosystem. In fact, inspecting a mathematical model is very much like a laboratory experiment – the main difference being that in modelling, the environment is artificial. <br />
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<div class="col_abstract"><br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Two"><br />
<p class="abstract_title">Simulation Results</p><br />
<p class="abstract_text"><br />
For all the complex calculations and mechanisms behind a model, it is without much worth if it cannot produce useful results. In general, 'useful results' are defined as successful predictions about the effects of modifying some parameter - if we can use a model to determine the effect of each variable upon the outcome, we can better design our system in the real world. <br />
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</a><br />
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<a href="https://static.igem.org/mediawiki/2013/8/89/BioInformatics.gif" data-lightbox="image-1" title="Bioinformatics Co-alteration Searching Algorithm UCL iGEM 2013"><br />
<img src="https://static.igem.org/mediawiki/2013/8/89/BioInformatics.gif"><br />
</a><br />
</div><br />
<br />
<div class="col_abstract"><br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Westminster"><br />
<p class="abstract_title">Westminster collaboration</p><br />
<p class="abstract_text"><br />
Since Westminster's iGEM team had not produced a model of their own, and their project has several similarities to ours, we have constructed an additional model, also in C#, and sent this to Westminster's team for them to use. The model simulates bed bugs moving randomly in a cubic room. One of their proposed "blood traps" is integrated into the simulation, which visually demonstrates bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
</a><br />
</div><br />
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</div><br />
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<div class="gap"><br />
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<p class="abstract_text">Using bioinformatics we can identify key genes whose dysfunction drives disease states. In so doing, we are should be able to come up with new parts that target these dysfunctional genes to increase the efficacy of synthetic biological constructs. <br />
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<p class="major_title">WESTMINSTER MODELING COLLABORATION</p><br />
<p class="minor_title">Another model based on the UCL simulation</p><br />
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<p class="body_text"><br />
Since Westminster's iGEM team had not produced a model of their own, and their project has several similarities to ours, we have constructed an additional model, also in C#, and sent this to Westminster's team for them to use. The model simulates bed bugs moving randomly in a cubic room. One of their proposed "blood traps" is integrated into the simulation, which visually demonstrates bed bugs being attracted and then subsequently killed by the device. <br />
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This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
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Below this animation are a couple of graphs demonstrating the potential uses of the model. The first shows the approach of a single bedbug to the device; note the random fluctuation in addition to the directional motion. The second graph shows the effect of room size on time taken for all bedbugs to reach the device and die.<br />
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<p class="body_text"><br />
<span class="plainlinks"><br />
<a href="https://2013.igem.org/Team:Westminster/Modelling" target="_blank"><br />
Click here to visit the Westminster iGEM collaboration page</a></span><br />
</p><br />
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<p class="major_title">DRY LAB</p><br />
<p class="minor_title">Modelling The Treatment And Finding New Parts</p><br />
<p class="abstract_text" style="color:#404040;"><br />
Awaiting Input.<br><br><br />
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<p class="abstract_text" style="color:#C14645;"><br />
Click the abstracts below to read more.<br />
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<a href="https://static.igem.org/mediawiki/2013/f/f3/Twobrain.png" data-lightbox="image-1" title="UCL iGEM 2013"><br />
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<p class="abstract_title">Model Overview</p><br />
<p class="abstract_text"><br />
Mathematical modelling provides a powerful tool for scientists of all disciplines, allowing inspection and manipulation of a system in ways which are unachievable in the lab. In the context of biology, we can use mathematical models to study the behaviour of a single cell or an entire ecosystem. In fact, inspecting a mathematical model is very much like a laboratory experiment – the main difference being that in modelling, the environment is artificial. <br />
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For all the complex calculations and mechanisms behind a model, it is without much worth if it cannot produce useful results. In general, 'useful results' are defined as successful predictions about the effects of modifying some parameter - if we can use a model to determine the effect of each variable upon the outcome, we can better design our system in the real world. <br />
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<p class="abstract_title">Westminster collaboration</p><br />
<p class="abstract_text"><br />
Since Westminster's iGEM team had not produced a model of their own, and their project has several similarities to ours, we have constructed an additional model, also in C#, and sent this to Westminster's team for them to use. The model simulates bed bugs moving randomly in a cubic room. One of their proposed "blood traps" is integrated into the simulation, which visually demonstrates bed bugs being attracted and then subsequently killed by the device. <br />
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<p class="abstract_title">Bioinformatics</p><br />
<p class="abstract_text">Using bioinformatics we can identify key genes whose dysfunction drives disease states. In so doing, we are should be able to come up with new parts that target these dysfunctional genes to increase the efficacy of synthetic biological constructs. <br />
</p><br />
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What were the skies like when you were young?<br />
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They were beautiful, the most beautiful skies as a <br />
matter of fact. The sunsets were purple and red and <br />
yellow and on fire, and the clouds would catch the <br />
colours everywhere.<br />
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Unfortunately, we are no longer accepting submissions. Scroll down to view Eternal Sunshine...<br />
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It's been a good journey thus far with StJohn's expertise in primer design. I will always remember the special bond in the form of Facebook messages consisting of DNA codes and scientific papers. Wishing StJohn a wonderful year in Montreal!<br />
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The memories of family holidays when you are young are such a mix of emotive events. Stress, arguments, adventure, taking in the wondrous sights of a new place... For me, they are the best of memories, because they distil the essence of what family is and inspire a love for travel.<br />
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I am not religious, but there is something awe inspiring about cathedrals. I suppose that's the point. I've visited many, and treasure these memories because they are a safe place to retreat to when things in the present get hectic.<br />
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This is me and some incredible young people I had the pleasure of teaching for a week at a summer camp in Romania. For me, the whole experience is a reminder of how many good people there are in the world, and how knowing people for such a short amount of time can still yield the richest memories and life-long friendships.<br />
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Going to Namibia and watching the elephants around the waterhole at sunset. They were the most beautiful animals I had ever seen. I hope I never forget this image.<br />
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This is a picture that evokes one of the best days of my life. To me its pictorial form represents a day that will never be replicated and perhaps even an era that has come to pass.<br />
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Visiting America and seeing amazing places like NYC with my best friend who I met online. Amazing in every way, from exploring, to knowing that there are no barriers to meeting fantastic people who can bring happiness into our life.<br />
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This is a photo of me and my grandparents from when I was little. As a child,I used to spend my summer holiday at my grandparents and those moments were the best moments of my life, the single time when I was truly happy day after day. I've never been as happy as then. Certainly I don't want to forget these memories! I want to keep those memories alive as well as my grandfather's image,who passed away a long time ago. Hope I will be able to cherish my childhood memories till my dying day.<br />
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Memories are whey are because of the people you share them with<br />
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This is my favourite object. Its special because it reminds me of personal discovery and surprise, and how surprises occur constantly, even in old environments.<br />
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This was the beginning of my time at uni. It was my first week with people who would become great friends. I've loved my time at uni and this photo reminds me of some the amazing times I have had there.<br />
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There is something mesmerizing about this place; I felt free and honored to be able to witness it.<br />
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Going home from hospital with my two lovely babies and my wonderful husband.<br />
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A time when life was fun, frivolous and uncomplicated!<br />
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Perfect day celebrating birthday and public holiday with friends and family in a gorgeous setting and the knowledge that I was newly pregnant with my son!<br />
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There's a cliff thats particularly soft and green. Underneath there's dark slate shattered everywhere and its nosey and dangerous, but when you lie down its silent, and the softness of the moss muffles everything so all you can see is the sky- even the wind just misses your face. Its the perfect place to just be.<br />
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It represents ambition, the past and the future.<br />
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The perpetual cocktail party.<br />
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The annual bonfire night gathering. The air was always so cold and crisp and nipped at our rosy little cheeks<br />
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My sister and I when we were toddlers.<br />
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2011, wild winter which I missed, but below the upsetting snow there are the stairs of my childhood which were climbed up and down for so many times by me and my father.<br />
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My most treasured memory. Having fun with a group of awesome people in a whole, as one family. <3<br />
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My one and only<br />
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My prom with my beloved one.<br />
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We went to Miss Kiew's house on her 18th birthday cause we are irreplaceable friends. ;P we da bombs. Went there and bully her. As usual. 😂<br />
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Leo Forum 2013 <br />
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Every moment spent with my family is worth remembering.<br />
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Good friends are hard to find, harder to leave, and impossible to forget.<br />
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Why is this memory so special to you?<br />
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Life-changing experience on a student exchange programme all the way to Melbourne, Australia.<br />
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Missing the fun and adventurous times with the best mates!<br />
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Dubrovnik 2012 - this was the view from our bedroom window!<br />
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The beginning of the first story I ever wrote: early 1970s Bermondsey shines through. The place has changed.<br />
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When young, I was often taken to see the high cliffs at Beachy Head. I would throw the stones hard. One time the tide had rushed in to the foot of the cliff and I thought the water looked like flames.<br />
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I used to sell had-drawn T-shirts around the markets in London. As time passed, hare-brained messes like this became rarer. Good fun though!<br />
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Aged 7, around the street there was a dirty greenhouse packed with Cacti in the small concrete front garden. One time, some vandals smashed it, so when my parents weren't looking, I leant over the fence at the maw of the cactus. It looked quite like this.<br />
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The island of La Graciosa, by Lanzarote. This is the first time I had ever seen such a deserted place. The wind was horribly strong, so the waves and foam were brightly lit by the sun. It looked like a scene from Walking with Dinosaurs.<br />
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His name is Domo and he has a friend called Axalotyl. He travels with me everywhere. Like me, he needs glasses because his eyes are minute and way too far apart.<br />
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Recently, I walked out of London, due Southeast on a hot summer's day. When the Voyager probe left the solar system, it took a final look at the planets which were splayed across the sky like London's new glass towers are over this cornfield.<br />
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One of my first gigs. I played to dinosaurs and whalebones.<br />
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When I slept here was terrified of the sound of rushing water. There were lots of strange weeds growing out of the cracks in in the foundations.<br />
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My first year in University, I would run out of the halls and up primrose hill. I had a choice at this stage whether I took the hill steeply or gently, but I was getting a weird mix of runner's high and sleep deprivation. This would be the place I'd aim for.<br />
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I get to this bit of the road on the way home, and I'd always be astonished by how grey it was. Look at it! They must have tried so hard!<br />
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This is the worst flat I ever lived in. I think I was almost electrocuted here.<br />
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On a bike by the lake just outside outside Beijing. It was completely still and the heat was oppressive. Shortly after I took this, an enormous fish (no idea what kind) leapt clean out of the water.<br />
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I had a day off work, so I spent a day reading a book watching people various people sleep on this bench.<br />
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This was from an extraordinary museum. It made me think of the circle of life. It lined a cast bronze bottle and it was lit by cream coloured lighting.<br />
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I camped in Cornwall and for the first time I saw vegetable grown on an industrial scale. That night, I dreamt of bins full of cauliflowers.<br />
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The one and only time I went to a large commercial music festival. It was in Ireland, so it was a mud bath. People fought in the mud. I wore a black coat, black trousers and black boots, and I realised to my surprise that people found me attractive...<br />
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Shanghai is the most stupidly large city I have ever seen. Until I saw it, Paris and London seemed like the centre of the world. I sat half awake in that jam and felt that shock for at least an hour.<br />
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One morning, just after the london riots, I was furious. Really furious and helpless, and I was essentially under curfew, so I went to Brighton. I knew the dawn was beautiful, but right then, those contrails looked like fish guts.<br />
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I saw a Van Gough like crow field. Silly but true.<br />
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I joined the Trinis in the Notting Hill Carnival. We threw chocolate milk about and sang until our throats ached as we went around the corner down Ladbroke Grove.<br />
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In Glasgow, the towers look like gravestones. I was recommended this place by the tourist office in midwinter. It was miserable, and this is about the only time I ever felt homesick.<br />
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From the depths of Dungeness. "Blue lines" by Massive Attack was blaring out of the hut just by me. I found the skeleton of this crab claw in the crunchy gravel and put it on a rusted iron box in front of the Power station. That felt perfect.<br />
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This is a stash of heavy iron balls I found in my garden in Plymouth. That's history.<br />
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Comments: I was dressed funny out on the rocks of Dun Laoghaire in Dublin bay. A wolfhound and a golden retriever walked calmly and gingerly over the rocks. I was after finding someone as serene walking the coast path. She looked a good bet, but she gave me a hard stare.<br />
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There was a sofa outside in the graveyard, knew it was going to go mouldy, but the summer was still young. There was even a small firepit. I wanted to show my girlfriend. One night some sausagehead let the whole thing burn. Nothing left but melted plastic and small resealable bags.<br />
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My brother found a pig mask, so we set out to do Halloween properly. I wore a hollowed pumpkin over my head, speared with marshmallows, candles and wet twigs. My friend wore a morph suit. He fed me a Favorite Chicken burger through my pumpkin-flap. We took the bus to Lewisham and paced the top of Blackheath. My candles hardly lit.<br />
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Camping. We made a nasty lunch out of the remaining food and we sat among the bracken and some of us got sunburnt. We had a speaker, so we listened to Satie's Gnossiennes and Brand New Second Hand. The trees looked more than just alive: they were out to get us. Some guys from the village fired spud guns at us.<br />
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The Council planted sunflowers in the park. - A special year.<br />
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If you have never had fresh noodles before, they are the most extraordinary thing. Try it.<br />
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It was when I saw it in a snowstorm that I realised what an effort of will Peckham is.<br />
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</html></div>21Robin12http://2013.igem.org/Team:UCL/MemoriesTeam:UCL/Memories2013-10-05T03:45:31Z<p>21Robin12: </p>
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What were the skies like when you were young?<br />
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They were beautiful, the most beautiful skies as a <br />
matter of fact. The sunsets were purple and red and <br />
yellow and on fire, and the clouds would catch the <br />
colours everywhere.<br />
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Unfortunately, we are no longer accepting submissions. Scroll down to view Eternal Sunshine...<br />
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It's been a good journey thus far with StJohn's expertise in primer design. I will always remember the special bond in the form of Facebook messages consisting of DNA codes and scientific papers. Wishing StJohn a wonderful year in Montreal!<br />
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The memories of family holidays when you are young are such a mix of emotive events. Stress, arguments, adventure, taking in the wondrous sights of a new place... For me, they are the best of memories, because they distil the essence of what family is and inspire a love for travel.<br />
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I am not religious, but there is something awe inspiring about cathedrals. I suppose that's the point. I've visited many, and treasure these memories because they are a safe place to retreat to when things in the present get hectic.<br />
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This is me and some incredible young people I had the pleasure of teaching for a week at a summer camp in Romania. For me, the whole experience is a reminder of how many good people there are in the world, and how knowing people for such a short amount of time can still yield the richest memories and life-long friendships.<br />
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Going to Namibia and watching the elephants around the waterhole at sunset. They were the most beautiful animals I had ever seen. I hope I never forget this image.<br />
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This is a picture that evokes one of the best days of my life. To me its pictorial form represents a day that will never be replicated and perhaps even an era that has come to pass.<br />
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Visiting America and seeing amazing places like NYC with my best friend who I met online. Amazing in every way, from exploring, to knowing that there are no barriers to meeting fantastic people who can bring happiness into our life.<br />
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This is a photo of me and my grandparents from when I was little. As a child,I used to spend my summer holiday at my grandparents and those moments were the best moments of my life, the single time when I was truly happy day after day. I've never been as happy as then. Certainly I don't want to forget these memories! I want to keep those memories alive as well as my grandfather's image,who passed away a long time ago. Hope I will be able to cherish my childhood memories till my dying day.<br />
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Memories are whey are because of the people you share them with<br />
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This is my favourite object. Its special because it reminds me of personal discovery and surprise, and how surprises occur constantly, even in old environments.<br />
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This was the beginning of my time at uni. It was my first week with people who would become great friends. I've loved my time at uni and this photo reminds me of some the amazing times I have had there.<br />
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There is something mesmerizing about this place; I felt free and honored to be able to witness it.<br />
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Going home from hospital with my two lovely babies and my wonderful husband.<br />
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A time when life was fun, frivolous and uncomplicated!<br />
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Perfect day celebrating birthday and public holiday with friends and family in a gorgeous setting and the knowledge that I was newly pregnant with my son!<br />
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There's a cliff thats particularly soft and green. Underneath there's dark slate shattered everywhere and its nosey and dangerous, but when you lie down its silent, and the softness of the moss muffles everything so all you can see is the sky- even the wind just misses your face. Its the perfect place to just be.<br />
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It represents ambition, the past and the future.<br />
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The perpetual cocktail party.<br />
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The annual bonfire night gathering. The air was always so cold and crisp and nipped at our rosy little cheeks<br />
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My sister and I when we were toddlers.<br />
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2011, wild winter which I missed, but below the upsetting snow there are the stairs of my childhood which were climbed up and down for so many times by me and my father.<br />
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My most treasured memory. Having fun with a group of awesome people in a whole, as one family. <3<br />
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My one and only<br />
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My prom with my beloved one.<br />
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We went to Miss Kiew's house on her 18th birthday cause we are irreplaceable friends. ;P we da bombs. Went there and bully her. As usual. 😂<br />
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Leo Forum 2013 <br />
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Every moment spent with my family is worth remembering.<br />
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Good friends are hard to find, harder to leave, and impossible to forget.<br />
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Why is this memory so special to you?<br />
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Life-changing experience on a student exchange programme all the way to Melbourne, Australia.<br />
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Missing the fun and adventurous times with the best mates!<br />
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Dubrovnik 2012 - this was the view from our bedroom window!<br />
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The beginning of the first story I ever wrote: early 1970s Bermondsey shines through. The place has changed.<br />
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When young, I was often taken to see the high cliffs at Beachy Head. I would throw the stones hard. One time the tide had rushed in to the foot of the cliff and I thought the water looked like flames.<br />
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I used to sell had-drawn T-shirts around the markets in London. As time passed, hare-brained messes like this became rarer. Good fun though!<br />
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Aged 7, around the street there was a dirty greenhouse packed with Cacti in the small concrete front garden. One time, some vandals smashed it, so when my parents weren't looking, I leant over the fence at the maw of the cactus. It looked quite like this.<br />
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The island of La Graciosa, by Lanzarote. This is the first time I had ever seen such a deserted place. The wind was horribly strong, so the waves and foam were brightly lit by the sun. It looked like a scene from Walking with Dinosaurs.<br />
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His name is Domo and he has a friend called Axalotyl. He travels with me everywhere. Like me, he needs glasses because his eyes are minute and way too far apart.<br />
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Recently, I walked out of London, due Southeast on a hot summer's day. When the Voyager probe left the solar system, it took a final look at the planets which were splayed across the sky like London's new glass towers are over this cornfield.<br />
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One of my first gigs. I played to dinosaurs and whalebones.<br />
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When I slept here was terrified of the sound of rushing water. There were lots of strange weeds growing out of the cracks in in the foundations.<br />
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My first year in University, I would run out of the halls and up primrose hill. I had a choice at this stage whether I took the hill steeply or gently, but I was getting a weird mix of runner's high and sleep deprivation. This would be the place I'd aim for.<br />
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I get to this bit of the road on the way home, and I'd always be astonished by how grey it was. Look at it! They must have tried so hard!<br />
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This is the worst flat I ever lived in. I think I was almost electrocuted here.<br />
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On a bike by the lake just outside outside Beijing. It was completely still and the heat was oppressive. Shortly after I took this, an enormous fish (no idea what kind) leapt clean out of the water.<br />
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I had a day off work, so I spent a day reading a book watching people various people sleep on this bench.<br />
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This was from an extraordinary museum. It made me think of the circle of life. It lined a cast bronze bottle and it was lit by cream coloured lighting.<br />
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I camped in Cornwall and for the first time I saw vegetable grown on an industrial scale. That night, I dreamt of bins full of cauliflowers.<br />
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The one and only time I went to a large commercial music festival. It was in Ireland, so it was a mud bath. People fought in the mud. I wore a black coat, black trousers and black boots, and I realised to my surprise that people found me attractive...<br />
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Shanghai is the most stupidly large city I have ever seen. Until I saw it, Paris and London seemed like the centre of the world. I sat half awake in that jam and felt that shock for at least an hour.<br />
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One morning, just after the london riots, I was furious. Really furious and helpless, and I was essentially under curfew, so I went to Brighton. I knew the dawn was beautiful, but right then, those contrails looked like fish guts.<br />
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I saw a Van Gough like crow field. Silly but true.<br />
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I joined the Trinis in the Notting Hill Carnival. We threw chocolate milk about and sang until our throats ached as we went around the corner down Ladbroke Grove.<br />
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In Glasgow, the towers look like gravestones. I was recommended this place by the tourist office in midwinter. It was miserable, and this is about the only time I ever felt homesick.<br />
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From the depths of Dungeness. "Blue lines" by Massive Attack was blaring out of the hut just by me. I found the skeleton of this crab claw in the crunchy gravel and put it on a rusted iron box in front of the Power station. That felt perfect.<br />
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This is a stash of heavy iron balls I found in my garden in Plymouth. That's history.<br />
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Comments: I was dressed funny out on the rocks of Dun Laoghaire in Dublin bay. A wolfhound and a golden retriever walked calmly and gingerly over the rocks. I was after finding someone as serene walking the coast path. She looked a good bet, but she gave me a hard stare.<br />
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There was a sofa outside in the graveyard, knew it was going to go mouldy, but the summer was still young. There was even a small firepit. I wanted to show my girlfriend. One night some sausagehead let the whole thing burn. Nothing left but melted plastic and small resealable bags.<br />
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My brother found a pig mask, so we set out to do Halloween properly. I wore a hollowed pumpkin over my head, speared with marshmallows, candles and wet twigs. My friend wore a morph suit. He fed me a Favorite Chicken burger through my pumpkin-flap. We took the bus to Lewisham and paced the top of Blackheath. My candles hardly lit.<br />
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Camping. We made a nasty lunch out of the remaining food and we sat among the bracken and some of us got sunburnt. We had a speaker, so we listened to Satie's Gnossiennes and Brand New Second Hand. The trees looked more than just alive: they were out to get us. Some guys from the village fired spud guns at us.<br />
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The Council planted sunflowers in the park. - A special year.<br />
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If you have never had fresh noodles before, they are the most extraordinary thing. Try it.<br />
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It was when I saw it in a snowstorm that I realised what an effort of will Peckham is.<br />
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</html></div>21Robin12http://2013.igem.org/Team:UCL/MemoriesTeam:UCL/Memories2013-10-05T03:43:45Z<p>21Robin12: </p>
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What were the skies like when you were young?<br />
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They were beautiful, the most beautiful skies as a <br />
matter of fact. The sunsets were purple and red and <br />
yellow and on fire, and the clouds would catch the <br />
colours everywhere.<br />
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<br>Click to learn more.<br />
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It's been a good journey thus far with StJohn's expertise in primer design. I will always remember the special bond in the form of Facebook messages consisting of DNA codes and scientific papers. Wishing StJohn a wonderful year in Montreal!<br />
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The memories of family holidays when you are young are such a mix of emotive events. Stress, arguments, adventure, taking in the wondrous sights of a new place... For me, they are the best of memories, because they distil the essence of what family is and inspire a love for travel.<br />
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I am not religious, but there is something awe inspiring about cathedrals. I suppose that's the point. I've visited many, and treasure these memories because they are a safe place to retreat to when things in the present get hectic.<br />
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This is me and some incredible young people I had the pleasure of teaching for a week at a summer camp in Romania. For me, the whole experience is a reminder of how many good people there are in the world, and how knowing people for such a short amount of time can still yield the richest memories and life-long friendships.<br />
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Going to Namibia and watching the elephants around the waterhole at sunset. They were the most beautiful animals I had ever seen. I hope I never forget this image.<br />
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This is a picture that evokes one of the best days of my life. To me its pictorial form represents a day that will never be replicated and perhaps even an era that has come to pass.<br />
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Visiting America and seeing amazing places like NYC with my best friend who I met online. Amazing in every way, from exploring, to knowing that there are no barriers to meeting fantastic people who can bring happiness into our life.<br />
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This is a photo of me and my grandparents from when I was little. As a child,I used to spend my summer holiday at my grandparents and those moments were the best moments of my life, the single time when I was truly happy day after day. I've never been as happy as then. Certainly I don't want to forget these memories! I want to keep those memories alive as well as my grandfather's image,who passed away a long time ago. Hope I will be able to cherish my childhood memories till my dying day.<br />
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Memories are whey are because of the people you share them with<br />
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This is my favourite object. Its special because it reminds me of personal discovery and surprise, and how surprises occur constantly, even in old environments.<br />
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This was the beginning of my time at uni. It was my first week with people who would become great friends. I've loved my time at uni and this photo reminds me of some the amazing times I have had there.<br />
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There is something mesmerizing about this place; I felt free and honored to be able to witness it.<br />
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Going home from hospital with my two lovely babies and my wonderful husband.<br />
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A time when life was fun, frivolous and uncomplicated!<br />
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Perfect day celebrating birthday and public holiday with friends and family in a gorgeous setting and the knowledge that I was newly pregnant with my son!<br />
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There's a cliff thats particularly soft and green. Underneath there's dark slate shattered everywhere and its nosey and dangerous, but when you lie down its silent, and the softness of the moss muffles everything so all you can see is the sky- even the wind just misses your face. Its the perfect place to just be.<br />
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It represents ambition, the past and the future.<br />
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The perpetual cocktail party.<br />
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The annual bonfire night gathering. The air was always so cold and crisp and nipped at our rosy little cheeks<br />
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My sister and I when we were toddlers.<br />
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2011, wild winter which I missed, but below the upsetting snow there are the stairs of my childhood which were climbed up and down for so many times by me and my father.<br />
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My most treasured memory. Having fun with a group of awesome people in a whole, as one family. <3<br />
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My one and only<br />
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My prom with my beloved one.<br />
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We went to Miss Kiew's house on her 18th birthday cause we are irreplaceable friends. ;P we da bombs. Went there and bully her. As usual. 😂<br />
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Leo Forum 2013 <br />
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Every moment spent with my family is worth remembering.<br />
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Good friends are hard to find, harder to leave, and impossible to forget.<br />
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Why is this memory so special to you?<br />
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Life-changing experience on a student exchange programme all the way to Melbourne, Australia.<br />
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Missing the fun and adventurous times with the best mates!<br />
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Dubrovnik 2012 - this was the view from our bedroom window!<br />
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The beginning of the first story I ever wrote: early 1970s Bermondsey shines through. The place has changed.<br />
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When young, I was often taken to see the high cliffs at Beachy Head. I would throw the stones hard. One time the tide had rushed in to the foot of the cliff and I thought the water looked like flames.<br />
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I used to sell had-drawn T-shirts around the markets in London. As time passed, hare-brained messes like this became rarer. Good fun though!<br />
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Aged 7, around the street there was a dirty greenhouse packed with Cacti in the small concrete front garden. One time, some vandals smashed it, so when my parents weren't looking, I leant over the fence at the maw of the cactus. It looked quite like this.<br />
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The island of La Graciosa, by Lanzarote. This is the first time I had ever seen such a deserted place. The wind was horribly strong, so the waves and foam were brightly lit by the sun. It looked like a scene from Walking with Dinosaurs.<br />
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His name is Domo and he has a friend called Axalotyl. He travels with me everywhere. Like me, he needs glasses because his eyes are minute and way too far apart.<br />
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Recently, I walked out of London, due Southeast on a hot summer's day. When the Voyager probe left the solar system, it took a final look at the planets which were splayed across the sky like London's new glass towers are over this cornfield.<br />
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One of my first gigs. I played to dinosaurs and whalebones.<br />
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When I slept here was terrified of the sound of rushing water. There were lots of strange weeds growing out of the cracks in in the foundations.<br />
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My first year in University, I would run out of the halls and up primrose hill. I had a choice at this stage whether I took the hill steeply or gently, but I was getting a weird mix of runner's high and sleep deprivation. This would be the place I'd aim for.<br />
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I get to this bit of the road on the way home, and I'd always be astonished by how grey it was. Look at it! They must have tried so hard!<br />
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This is the worst flat I ever lived in. I think I was almost electrocuted here.<br />
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On a bike by the lake just outside outside Beijing. It was completely still and the heat was oppressive. Shortly after I took this, an enormous fish (no idea what kind) leapt clean out of the water.<br />
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I had a day off work, so I spent a day reading a book watching people various people sleep on this bench.<br />
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This was from an extraordinary museum. It made me think of the circle of life. It lined a cast bronze bottle and it was lit by cream coloured lighting.<br />
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I camped in Cornwall and for the first time I saw vegetable grown on an industrial scale. That night, I dreamt of bins full of cauliflowers.<br />
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The one and only time I went to a large commercial music festival. It was in Ireland, so it was a mud bath. People fought in the mud. I wore a black coat, black trousers and black boots, and I realised to my surprise that people found me attractive...<br />
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Shanghai is the most stupidly large city I have ever seen. Until I saw it, Paris and London seemed like the centre of the world. I sat half awake in that jam and felt that shock for at least an hour.<br />
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One morning, just after the london riots, I was furious. Really furious and helpless, and I was essentially under curfew, so I went to Brighton. I knew the dawn was beautiful, but right then, those contrails looked like fish guts.<br />
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I saw a Van Gough like crow field. Silly but true.<br />
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I joined the Trinis in the Notting Hill Carnival. We threw chocolate milk about and sang until our throats ached as we went around the corner down Ladbroke Grove.<br />
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In Glasgow, the towers look like gravestones. I was recommended this place by the tourist office in midwinter. It was miserable, and this is about the only time I ever felt homesick.<br />
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From the depths of Dungeness. "Blue lines" by Massive Attack was blaring out of the hut just by me. I found the skeleton of this crab claw in the crunchy gravel and put it on a rusted iron box in front of the Power station. That felt perfect.<br />
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This is a stash of heavy iron balls I found in my garden in Plymouth. That's history.<br />
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Comments: I was dressed funny out on the rocks of Dun Laoghaire in Dublin bay. A wolfhound and a golden retriever walked calmly and gingerly over the rocks. I was after finding someone as serene walking the coast path. She looked a good bet, but she gave me a hard stare.<br />
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There was a sofa outside in the graveyard, knew it was going to go mouldy, but the summer was still young. There was even a small firepit. I wanted to show my girlfriend. One night some sausagehead let the whole thing burn. Nothing left but melted plastic and small resealable bags.<br />
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My brother found a pig mask, so we set out to do Halloween properly. I wore a hollowed pumpkin over my head, speared with marshmallows, candles and wet twigs. My friend wore a morph suit. He fed me a Favorite Chicken burger through my pumpkin-flap. We took the bus to Lewisham and paced the top of Blackheath. My candles hardly lit.<br />
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Camping. We made a nasty lunch out of the remaining food and we sat among the bracken and some of us got sunburnt. We had a speaker, so we listened to Satie's Gnossiennes and Brand New Second Hand. The trees looked more than just alive: they were out to get us. Some guys from the village fired spud guns at us.<br />
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The Council planted sunflowers in the park. - A special year.<br />
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If you have never had fresh noodles before, they are the most extraordinary thing. Try it.<br />
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It was when I saw it in a snowstorm that I realised what an effort of will Peckham is.<br />
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</html></div>21Robin12http://2013.igem.org/Team:UCL/AchievementsTeam:UCL/Achievements2013-10-05T03:35:27Z<p>21Robin12: </p>
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<p class="major_title">MEDAL CRITERIA</p><br />
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<p class="minor_title">Bronze Medal</p><br />
<div class="full_row"><br />
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<p class="body_text"><br />
• We have registered our <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">team</a> of eleven undergraduates. <br />
</p><br />
<p class="body_text"><br />
• We have completed the judging form.<br />
</p><br />
<p class="body_text"><br />
• We have created a beautiful team wiki in keeping with the iGEM guidelines.<br />
</p><br />
<p class="body_text"><br />
• We have a poster and presentation ready for the regional jamboree in Lyon.<br />
</p><br />
<p class="body_text"><br />
• We have developed two new <a href="https://2013.igem.org/Team:UCL/Project/Parts" target="_blank">BioBricks</a> and have submitted them to the iGEM Registry<br />
</div><br />
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<p class="minor_title">Silver Medal</p><br />
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• We have proved our zeocin resistance BioBrick <a href="https://2013.igem.org/Team:UCL/Project/Parts" target="_blank">worked as expected</a> by characterising it in HeLa cells. We did this by by creating a zeocin kill curve with and without our <a href="https://2013.igem.org/Team:UCL/Project/Marker" target="_blank">zeocin resistance</a> BioBrick. <br />
</p><br />
<p class="body_text"><br />
• Due to the gravity of Alzheimer's disease and the perceived sovereignty of the brain, we have taken the ethics of using synthetic biological treatments very seriously. We produced a <a href="https://2013.igem.org/Team:UCL/Practice/Neuroethics" target="_blank">neuroethics</a> and a <a href="https://2013.igem.org/Team:UCL/Practice/Report" target="_blank">feasibility</a> report, consulted numerous experts and provided a concise but detailed <a href="https://2013.igem.org/Team:UCL/Background" target="_blank">background</a> to our project, which shows how our proposed <a href="https://2013.igem.org/Team:UCL/Project/Circuit" target="_blank">genetic circuit</a> is advised by multiple theories for the causation of Alzheimer's pathology.<br />
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Gold Medal<br />
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<p class="body_text"><br />
• We collaborated with iGEM Westminster, by modelling how well their bed-bug killing device will operate in a bedroom as well advising them on how to run a speed debate using our format. One of our team members, Alex Bates, also attended as guest speaker at their speed debate event.<br />
</p><br />
<p class="body_text"><br />
Full details on collaboration with iGEM Westminster can be found below.<br />
</p><br />
<p class="body_text"><br />
• Our <a href="https://2013.igem.org/Team:UCL/Project/Circuit" target="_blank">Human Practices</a> deal with an entirely new area for iGEM and, indeed, almost a completely new avenue of research for synthetic biology as a field - the <a href="https://2013.igem.org/Team:UCL/Practice/Neuroethics" target="_blank">fusion</a> of neuroscience and synthetic biology. We use a variety of strong methods for social and ethical analysis, and outreach. Please see the section below for a summary of what we achieved.<br />
</p><br />
<p class="body_text"><br />
• Outside of this theme, we also engaged in outreach by training and advising the UCL Academy iGEM high school team. This was the first time a British iGEM team has helped run an iGEM HS team.<br />
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<p class="major_title">ABOVE AND BEYOND</p><br />
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<p class="minor_title">Project</p><br />
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• Developed and experimentally validated the first selectable marker (Zeocin) in a mammalian system (HeLa cells). <br />
</p><br />
<p class="body_text"><br />
• Plan to use genetically engineered microglia cells; the first human brain cells to be used in iGEM, when they arrive so results will be available post jamboree. <br />
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<p class="minor_title">Human Practices</p><br />
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• We have looked at an entirely new ethical area for iGEM that has also essentially not been covered in academia; the neuroethics of genetic engineering. We have dubbed this <a href="https://2013.igem.org/Team:UCL/Practice" target="_blank">'Neuro-genethics'</a>. <br />
</p><br />
<p class="body_text"><br />
• We have produced an extensive 20 page <a href="https://2013.igem.org/Team:UCL/Practice/Neuroethics" target="_blank">report</a> that looks into neuro-genethics and what synthetic biology could achieve in neuroscience.<br />
</p><br />
<p class="body_text"><br />
• We have engaged the public on this topic by getting their opinions at the <a href="http://www.artscatalyst.org/" target="_blank">Arts Catalyst</a>, running a <a href="https://2013.igem.org/Team:UCL/Practice/Debate" target="_blank">speed debate</a> and a <a href="https://2013.igem.org/Team:UCL/Practice/TED" target="_blank">TED debate</a>, conducting an <a href="https://2013.igem.org/Team:UCL/Practice/Survey" target="_blank">online survey</a> and producing a <a href="https://2013.igem.org/Team:UCL/Practice/Documentary" target="_blank">documentary </a> on synthetic neurobiology.<br />
</p><br />
<p class="body_text"><br />
• We ran one of iGEM's first <a href="https://2013.igem.org/Team:UCL/Practice/Creative" target="_blank">creative writing competitions</a>, to gauge public opinion on brain modification and highlight the impact of fiction on society's views.<br />
</p><br />
<p class="body_text"><br />
• Petcha Kutcha style presentation to enguage prospective students of the UCL Engineering Department about iGEM.<br />
</p><br />
<p class="body_text"><br />
• We created an original memory bank, <a href="https://2013.igem.org/Team:UCL/Memories" target="_blank">Eternal Sunshine</a>, which highlights how precious memories are, indicating the desperate need to cure Alzheimer's disease. <br />
</p><br />
<p class="body_text"><br />
• We created a <a href="https://2013.igem.org/Team:UCL/Practice/Report" target="_blank">feasibility report</a> on implementing our treatment.<br />
</p><br />
<p class="body_text"><br />
• Attended and aided in the running of YSB 1.0 (held at UCL) along with other UK iGEM teams to discuss projects and potential collaborations. <br />
</p><br />
<p class="body_text"><br />
• Through Eternal Sunshine and the creative writing competition we have successfully reached out to a diverse range of people from every corner of the globe, from the USA , to China, to Saudi Arabia and so on. <br />
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<p class="minor_title">Modelling</p><br />
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• We are the first iGEM team to use a <a href="https://2013.igem.org/Team:UCL/Modeling" target="_blank">protein network analysis approach</a>. Network based bioinformatics can feedback into synthetic biology by informing the choice of parts in therapeutic genetic circuits.<br />
</p><br />
<p class="body_text"><br />
• We have developed <a href="https://2013.igem.org/Team:UCL/Modeling/Overview" target="_blank">an advanced piece of software</a> in C# with both numerical and graphical output. The model takes into account all major elements of the proposed mechanism.<br />
</p><br />
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• We have used the model to qualitatively demonstrate the feasibility of our proposed mechanism – setting all variables with their real values, microglia cells effectively clear plaques from a region of the brain.<br />
</p><br />
<p class="body_text"><br />
• We have also used our model to <a href="https://2013.igem.org/Team:UCL/Modeling/Two" target="_blank">investigate the effect of altering various parameters</a>. Although the model is artificial, since it accurately represents the real world, the results of these investigations could be used to better design our plaque clearing mechanism. Additionally, we used the model to produce an accelerated-time animation of microglia cells clearing plaques, and 3D images of signal distribution once simulation is complete.<br />
</p><br />
<p class="body_text"><br />
• We have made the entire source code available <span class="plainlinks"><a href="https://github.com/21robin12/ucligemmodel" target="_blank">via GitHub</a></span>.<br />
</p><br />
<p class="body_text"><br />
• Furthermore, we have developed <a href="https://2013.igem.org/Team:Westminster/Modelling" target="_blank">an entirely separate model for the Westminster iGEM team</a>. The entire source code for this has been sent to them for further development, in addition to a published version of the software which members of their team, even those without any coding experience, can use.<br />
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<p class="minor_title">Wiki</p><br />
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• We have developed an, original attractive wiki using art work by our artists in residence, <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Fong Yi Khoo</a> and <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Oran Maguire</a>.<br />
</p><br />
<p class="body_text"><br />
• We have included an extensive neuroscience background section, which explains and compares multiple theories for the causation of Alzheimer's disease, so that readers can fully understand the pros and cons of our genetic circuit. <br />
</p><br />
<p class="body_text"><br />
• We have included a full complement of citations that link to PubMed pages so that it is easy to see from where our ideas and explanations have been drawn, and which papers have inspired us.<br />
</p><br />
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<p class="minor_title">Collaboration with Westminster iGEM</p><br />
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<b>Model (ROBIN WRITES HERE)</b><br />
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Movement of bed-bugs towards blood meal<br />
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<p class="minor_title">Mentoring iGEM HS</p><br />
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Two members of the UCL iGEM team volunteered as advisers to the UCL Academy iGEM team – <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Ruxi</a> and <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Khaicheng</a>, under the guidance of Aurelija Grigonyte, a member of the UCL iGEM 2012 team. During the high school team’s brainstorming process, we provided them with guidance and resources for their research. We also supervised their lab work in the UCL Biochemical Engineering department.<br />
</p><br />
<p class="body_text"><br />
UCL is the first university in the UK to be the sole sponsor of an academy – a non-selective mixed state school in our home borough of Camden. UCL Academy represents a unique opportunity to blur the boundaries between secondary and higher education.<br />
</p><br />
<p class="body_text"><br />
The academy is one of the first UK high schools to participate in iGEM this year, and is the only UK team so far to have attended the <a href="https://2013hs.igem.org/Main_Page" target="_blank">High School iGEM Jamboree</a> at MIT, Boston. The team aimed to revolutionise the recycling industry by proposing a home system that converts cellulose into glucose, allowing the up-cycling of paper into a commercial product of bioplastic - polyhydroxybutyrate (PHB) <br />
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For information about their iGEM project, check out their wiki <a href="https://2013hs.igem.org/Team:UCL_Academy" target="_blank">here</a>. <br />
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</html></div>21Robin12http://2013.igem.org/Team:UCL/AchievementsTeam:UCL/Achievements2013-10-05T03:34:38Z<p>21Robin12: </p>
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<p class="major_title">MEDAL CRITERIA</p><br />
<br />
<p class="minor_title">Bronze Medal</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
• We have registered our <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">team</a> of eleven undergraduates. <br />
</p><br />
<p class="body_text"><br />
• We have completed the judging form.<br />
</p><br />
<p class="body_text"><br />
• We have created a beautiful team wiki in keeping with the iGEM guidelines.<br />
</p><br />
<p class="body_text"><br />
• We have a poster and presentation ready for the regional jamboree in Lyon.<br />
</p><br />
<p class="body_text"><br />
• We have developed two new <a href="https://2013.igem.org/Team:UCL/Project/Parts" target="_blank">BioBricks</a> and have submitted them to the iGEM Registry<br />
</div><br />
<br />
<p class="minor_title">Silver Medal</p><br />
<div class="full_row"><br />
<div class="gap"><br />
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<p class="body_text"><br />
• We have proved our zeocin resistance BioBrick <a href="https://2013.igem.org/Team:UCL/Project/Parts" target="_blank">worked as expected</a> by characterising it in HeLa cells. We did this by by creating a zeocin kill curve with and without our <a href="https://2013.igem.org/Team:UCL/Project/Marker" target="_blank">zeocin resistance</a> BioBrick. <br />
</p><br />
<p class="body_text"><br />
• Due to the gravity of Alzheimer's disease and the perceived sovereignty of the brain, we have taken the ethics of using synthetic biological treatments very seriously. We produced a <a href="https://2013.igem.org/Team:UCL/Practice/Neuroethics" target="_blank">neuroethics</a> and a <a href="https://2013.igem.org/Team:UCL/Practice/Report" target="_blank">feasibility</a> report, consulted numerous experts and provided a concise but detailed <a href="https://2013.igem.org/Team:UCL/Background" target="_blank">background</a> to our project, which shows how our proposed <a href="https://2013.igem.org/Team:UCL/Project/Circuit" target="_blank">genetic circuit</a> is advised by multiple theories for the causation of Alzheimer's pathology.<br />
</p><br />
</div><br />
<br />
<p class="minor_title"><br />
Gold Medal<br />
</p><br />
<div class="full_row"><br />
<div class="gap"><br />
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</p><br />
<p class="body_text"><br />
• We collaborated with iGEM Westminster, by modelling how well their bed-bug killing device will operate in a bedroom as well advising them on how to run a speed debate using our format. One of our team members, Alex Bates, also attended as guest speaker at their speed debate event.<br />
</p><br />
<p class="body_text"><br />
Full details on collaboration with iGEM Westminster can be found below.<br />
</p><br />
<p class="body_text"><br />
• Our <a href="https://2013.igem.org/Team:UCL/Project/Circuit" target="_blank">Human Practices</a> deal with an entirely new area for iGEM and, indeed, almost a completely new avenue of research for synthetic biology as a field - the <a href="https://2013.igem.org/Team:UCL/Practice/Neuroethics" target="_blank">fusion</a> of neuroscience and synthetic biology. We use a variety of strong methods for social and ethical analysis, and outreach. Please see the section below for a summary of what we achieved.<br />
</p><br />
<p class="body_text"><br />
• Outside of this theme, we also engaged in outreach by training and advising the UCL Academy iGEM high school team. This was the first time a British iGEM team has helped run an iGEM HS team.<br />
</p><br />
</div><br />
<br />
<div class="gap"><br />
</div><br />
<br />
<p class="major_title">ABOVE AND BEYOND</p><br />
<br />
<p class="minor_title">Project</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
• Developed and experimentally validated the first selectable marker (Zeocin) in a mammalian system (HeLa cells). <br />
</p><br />
<p class="body_text"><br />
• Plan to use genetically engineered microglia cells; the first human brain cells to be used in iGEM, when they arrive so results will be available post jamboree. <br />
</p><br />
</div><br />
<br />
<p class="minor_title">Human Practices</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
• We have looked at an entirely new ethical area for iGEM that has also essentially not been covered in academia; the neuroethics of genetic engineering. We have dubbed this <a href="https://2013.igem.org/Team:UCL/Practice" target="_blank">'Neuro-genethics'</a>. <br />
</p><br />
<p class="body_text"><br />
• We have produced an extensive 20 page <a href="https://2013.igem.org/Team:UCL/Practice/Neuroethics" target="_blank">report</a> that looks into neuro-genethics and what synthetic biology could achieve in neuroscience.<br />
</p><br />
<p class="body_text"><br />
• We have engaged the public on this topic by getting their opinions at the <a href="http://www.artscatalyst.org/" target="_blank">Arts Catalyst</a>, running a <a href="https://2013.igem.org/Team:UCL/Practice/Debate" target="_blank">speed debate</a> and a <a href="https://2013.igem.org/Team:UCL/Practice/TED" target="_blank">TED debate</a>, conducting an <a href="https://2013.igem.org/Team:UCL/Practice/Survey" target="_blank">online survey</a> and producing a <a href="https://2013.igem.org/Team:UCL/Practice/Documentary" target="_blank">documentary </a> on synthetic neurobiology.<br />
</p><br />
<p class="body_text"><br />
• We ran one of iGEM's first <a href="https://2013.igem.org/Team:UCL/Practice/Creative" target="_blank">creative writing competitions</a>, to gauge public opinion on brain modification and highlight the impact of fiction on society's views.<br />
</p><br />
<p class="body_text"><br />
• Petcha Kutcha style presentation to enguage prospective students of the UCL Engineering Department about iGEM.<br />
</p><br />
<p class="body_text"><br />
• We created an original memory bank, <a href="https://2013.igem.org/Team:UCL/Memories" target="_blank">Eternal Sunshine</a>, which highlights how precious memories are, indicating the desperate need to cure Alzheimer's disease. <br />
</p><br />
<p class="body_text"><br />
• We created a <a href="https://2013.igem.org/Team:UCL/Practice/Report" target="_blank">feasibility report</a> on implementing our treatment.<br />
</p><br />
<p class="body_text"><br />
• Attended and aided in the running of YSB 1.0 (held at UCL) along with other UK iGEM teams to discuss projects and potential collaborations. <br />
</p><br />
<p class="body_text"><br />
• Through Eternal Sunshine and the creative writing competition we have successfully reached out to a diverse range of people from every corner of the globe, from the USA , to China, to Saudi Arabia and so on. <br />
</p><br />
</div><br />
<br />
<p class="minor_title">Modelling</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
• We are the first iGEM team to use a <a href="https://2013.igem.org/Team:UCL/Modeling" target="_blank">protein network analysis approach</a>. Network based bioinformatics can feedback into synthetic biology by informing the choice of parts in therapeutic genetic circuits.<br />
</p><br />
<p class="body_text"><br />
• We have developed <a href="https://2013.igem.org/Team:UCL/Modeling/Overview" target="_blank">an advanced piece of software</a> in C# with both numerical and graphical output. The model takes into account all major elements of the proposed mechanism.<br />
</p><br />
<p class="body_text"><br />
• We have used the model to qualitatively demonstrate the feasibility of our proposed mechanism – setting all variables with their real values, microglia cells effectively clear plaques from a region of the brain.<br />
</p><br />
<p class="body_text"><br />
• We have also used our model to <a href="https://2013.igem.org/Team:UCL/Modeling/Two" target="_blank">investigate the effect of altering various parameters</a>. Although the model is artificial, since it accurately represents the real world, the results of these investigations could be used to better design our plaque clearing mechanism. Additionally, we used the model to produce an accelerated-time animation of microglia cells clearing plaques, and 3D images of signal distribution once simulation is complete.<br />
</p><br />
<p class="body_text"><br />
• We have made the entire source code available <a href="https://github.com/21robin12/ucligemmodel" target="_blank">via GitHub</a>.<br />
</p><br />
<p class="body_text"><br />
• Furthermore, we have developed <a href="https://2013.igem.org/Team:Westminster/Modelling" target="_blank">an entirely separate model for the Westminster iGEM team</a>. The entire source code for this has been sent to them for further development, in addition to a published version of the software which members of their team, even those without any coding experience, can use.<br />
</p<br />
<br />
<br />
<br />
<br />
</p><br />
</div><br />
<br />
<p class="minor_title">Wiki</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
• We have developed an, original attractive wiki using art work by our artists in residence, <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Fong Yi Khoo</a> and <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Oran Maguire</a>.<br />
</p><br />
<p class="body_text"><br />
• We have included an extensive neuroscience background section, which explains and compares multiple theories for the causation of Alzheimer's disease, so that readers can fully understand the pros and cons of our genetic circuit. <br />
</p><br />
<p class="body_text"><br />
• We have included a full complement of citations that link to PubMed pages so that it is easy to see from where our ideas and explanations have been drawn, and which papers have inspired us.<br />
</p><br />
</div><br />
<br />
<p class="minor_title">Collaboration with Westminster iGEM</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
<b>Model (ROBIN WRITES HERE)</b><br />
</p><br />
<p class="body_text"><br />
Movement of bed-bugs towards blood meal<br />
</div><br />
<br />
<p class="minor_title">Mentoring iGEM HS</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
Two members of the UCL iGEM team volunteered as advisers to the UCL Academy iGEM team – <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Ruxi</a> and <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Khaicheng</a>, under the guidance of Aurelija Grigonyte, a member of the UCL iGEM 2012 team. During the high school team’s brainstorming process, we provided them with guidance and resources for their research. We also supervised their lab work in the UCL Biochemical Engineering department.<br />
</p><br />
<p class="body_text"><br />
UCL is the first university in the UK to be the sole sponsor of an academy – a non-selective mixed state school in our home borough of Camden. UCL Academy represents a unique opportunity to blur the boundaries between secondary and higher education.<br />
</p><br />
<p class="body_text"><br />
The academy is one of the first UK high schools to participate in iGEM this year, and is the only UK team so far to have attended the <a href="https://2013hs.igem.org/Main_Page" target="_blank">High School iGEM Jamboree</a> at MIT, Boston. The team aimed to revolutionise the recycling industry by proposing a home system that converts cellulose into glucose, allowing the up-cycling of paper into a commercial product of bioplastic - polyhydroxybutyrate (PHB) <br />
</p><br />
</p><br />
<div class="small_image_right" style="background-image:url('https://static.igem.org/mediawiki/2013/b/b0/IMG_4769-1024x68211.jpg');height:280px;width:650px;"><br />
</div><br />
</p><br />
<p class="body_text"><br />
For information about their iGEM project, check out their wiki <a href="https://2013hs.igem.org/Team:UCL_Academy" target="_blank">here</a>. <br />
</p><br />
</div><br />
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</html></div>21Robin12http://2013.igem.org/Team:UCL/AchievementsTeam:UCL/Achievements2013-10-05T03:33:52Z<p>21Robin12: </p>
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<p class="major_title">MEDAL CRITERIA</p><br />
<br />
<p class="minor_title">Bronze Medal</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
• We have registered our <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">team</a> of eleven undergraduates. <br />
</p><br />
<p class="body_text"><br />
• We have completed the judging form.<br />
</p><br />
<p class="body_text"><br />
• We have created a beautiful team wiki in keeping with the iGEM guidelines.<br />
</p><br />
<p class="body_text"><br />
• We have a poster and presentation ready for the regional jamboree in Lyon.<br />
</p><br />
<p class="body_text"><br />
• We have developed two new <a href="https://2013.igem.org/Team:UCL/Project/Parts" target="_blank">BioBricks</a> and have submitted them to the iGEM Registry<br />
</div><br />
<br />
<p class="minor_title">Silver Medal</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
• We have proved our zeocin resistance BioBrick <a href="https://2013.igem.org/Team:UCL/Project/Parts" target="_blank">worked as expected</a> by characterising it in HeLa cells. We did this by by creating a zeocin kill curve with and without our <a href="https://2013.igem.org/Team:UCL/Project/Marker" target="_blank">zeocin resistance</a> BioBrick. <br />
</p><br />
<p class="body_text"><br />
• Due to the gravity of Alzheimer's disease and the perceived sovereignty of the brain, we have taken the ethics of using synthetic biological treatments very seriously. We produced a <a href="https://2013.igem.org/Team:UCL/Practice/Neuroethics" target="_blank">neuroethics</a> and a <a href="https://2013.igem.org/Team:UCL/Practice/Report" target="_blank">feasibility</a> report, consulted numerous experts and provided a concise but detailed <a href="https://2013.igem.org/Team:UCL/Background" target="_blank">background</a> to our project, which shows how our proposed <a href="https://2013.igem.org/Team:UCL/Project/Circuit" target="_blank">genetic circuit</a> is advised by multiple theories for the causation of Alzheimer's pathology.<br />
</p><br />
</div><br />
<br />
<p class="minor_title"><br />
Gold Medal<br />
</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
</p><br />
<p class="body_text"><br />
• We collaborated with iGEM Westminster, by modelling how well their bed-bug killing device will operate in a bedroom as well advising them on how to run a speed debate using our format. One of our team members, Alex Bates, also attended as guest speaker at their speed debate event.<br />
</p><br />
<p class="body_text"><br />
Full details on collaboration with iGEM Westminster can be found below.<br />
</p><br />
<p class="body_text"><br />
• Our <a href="https://2013.igem.org/Team:UCL/Project/Circuit" target="_blank">Human Practices</a> deal with an entirely new area for iGEM and, indeed, almost a completely new avenue of research for synthetic biology as a field - the <a href="https://2013.igem.org/Team:UCL/Practice/Neuroethics" target="_blank">fusion</a> of neuroscience and synthetic biology. We use a variety of strong methods for social and ethical analysis, and outreach. Please see the section below for a summary of what we achieved.<br />
</p><br />
<p class="body_text"><br />
• Outside of this theme, we also engaged in outreach by training and advising the UCL Academy iGEM high school team. This was the first time a British iGEM team has helped run an iGEM HS team.<br />
</p><br />
</div><br />
<br />
<div class="gap"><br />
</div><br />
<br />
<p class="major_title">ABOVE AND BEYOND</p><br />
<br />
<p class="minor_title">Project</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
• Developed and experimentally validated the first selectable marker (Zeocin) in a mammalian system (HeLa cells). <br />
</p><br />
<p class="body_text"><br />
• Plan to use genetically engineered microglia cells; the first human brain cells to be used in iGEM, when they arrive so results will be available post jamboree. <br />
</p><br />
</div><br />
<br />
<p class="minor_title">Human Practices</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
• We have looked at an entirely new ethical area for iGEM that has also essentially not been covered in academia; the neuroethics of genetic engineering. We have dubbed this <a href="https://2013.igem.org/Team:UCL/Practice" target="_blank">'Neuro-genethics'</a>. <br />
</p><br />
<p class="body_text"><br />
• We have produced an extensive 20 page <a href="https://2013.igem.org/Team:UCL/Practice/Neuroethics" target="_blank">report</a> that looks into neuro-genethics and what synthetic biology could achieve in neuroscience.<br />
</p><br />
<p class="body_text"><br />
• We have engaged the public on this topic by getting their opinions at the <a href="http://www.artscatalyst.org/" target="_blank">Arts Catalyst</a>, running a <a href="https://2013.igem.org/Team:UCL/Practice/Debate" target="_blank">speed debate</a> and a <a href="https://2013.igem.org/Team:UCL/Practice/TED" target="_blank">TED debate</a>, conducting an <a href="https://2013.igem.org/Team:UCL/Practice/Survey" target="_blank">online survey</a> and producing a <a href="https://2013.igem.org/Team:UCL/Practice/Documentary" target="_blank">documentary </a> on synthetic neurobiology.<br />
</p><br />
<p class="body_text"><br />
• We ran one of iGEM's first <a href="https://2013.igem.org/Team:UCL/Practice/Creative" target="_blank">creative writing competitions</a>, to gauge public opinion on brain modification and highlight the impact of fiction on society's views.<br />
</p><br />
<p class="body_text"><br />
• Petcha Kutcha style presentation to enguage prospective students of the UCL Engineering Department about iGEM.<br />
</p><br />
<p class="body_text"><br />
• We created an original memory bank, <a href="https://2013.igem.org/Team:UCL/Memories" target="_blank">Eternal Sunshine</a>, which highlights how precious memories are, indicating the desperate need to cure Alzheimer's disease. <br />
</p><br />
<p class="body_text"><br />
• We created a <a href="https://2013.igem.org/Team:UCL/Practice/Report" target="_blank">feasibility report</a> on implementing our treatment.<br />
</p><br />
<p class="body_text"><br />
• Attended and aided in the running of YSB 1.0 (held at UCL) along with other UK iGEM teams to discuss projects and potential collaborations. <br />
</p><br />
<p class="body_text"><br />
• Through Eternal Sunshine and the creative writing competition we have successfully reached out to a diverse range of people from every corner of the globe, from the USA , to China, to Saudi Arabia and so on. <br />
</p><br />
</div><br />
<br />
<p class="minor_title">Modelling</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
• We are the first iGEM team to use a <a href="https://2013.igem.org/Team:UCL/Modeling" target="_blank">protein network analysis approach</a>. Network based bioinformatics can feedback into synthetic biology by informing the choice of parts in therapeutic genetic circuits.<br />
• We have developed <a href="https://2013.igem.org/Team:UCL/Modeling/Overview" target="_blank">an advanced piece of software</a> in C# with both numerical and graphical output. The model takes into account all major elements of the proposed mechanism.<br />
• We have used the model to qualitatively demonstrate the feasibility of our proposed mechanism – setting all variables with their real values, microglia cells effectively clear plaques from a region of the brain.<br />
• We have also used our model to <a href="https://2013.igem.org/Team:UCL/Modeling/Two" target="_blank">investigate the effect of altering various parameters</a>. Although the model is artificial, since it accurately represents the real world, the results of these investigations could be used to better design our plaque clearing mechanism. Additionally, we used the model to produce an accelerated-time animation of microglia cells clearing plaques, and 3D images of signal distribution once simulation is complete.<br />
• We have made the entire source code available <a href="https://github.com/21robin12/ucligemmodel" target="_blank">via GitHub</a>.<br />
• Furthermore, we have developed <a href="https://2013.igem.org/Team:Westminster/Modelling" target="_blank">an entirely separate model for the Westminster iGEM team</a>. The entire source code for this has been sent to them for further development, in addition to a published version of the software which members of their team, even those without any coding experience, can use.<br />
<br />
<br />
<br />
<br />
</p><br />
</div><br />
<br />
<p class="minor_title">Wiki</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
• We have developed an, original attractive wiki using art work by our artists in residence, <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Fong Yi Khoo</a> and <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Oran Maguire</a>.<br />
</p><br />
<p class="body_text"><br />
• We have included an extensive neuroscience background section, which explains and compares multiple theories for the causation of Alzheimer's disease, so that readers can fully understand the pros and cons of our genetic circuit. <br />
</p><br />
<p class="body_text"><br />
• We have included a full complement of citations that link to PubMed pages so that it is easy to see from where our ideas and explanations have been drawn, and which papers have inspired us.<br />
</p><br />
</div><br />
<br />
<p class="minor_title">Collaboration with Westminster iGEM</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
<b>Model (ROBIN WRITES HERE)</b><br />
</p><br />
<p class="body_text"><br />
Movement of bed-bugs towards blood meal<br />
</div><br />
<br />
<p class="minor_title">Mentoring iGEM HS</p><br />
<div class="full_row"><br />
<div class="gap"><br />
</div><br />
<p class="body_text"><br />
Two members of the UCL iGEM team volunteered as advisers to the UCL Academy iGEM team – <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Ruxi</a> and <a href="https://2013.igem.org/Team:UCL/Team/Profile" target="_blank">Khaicheng</a>, under the guidance of Aurelija Grigonyte, a member of the UCL iGEM 2012 team. During the high school team’s brainstorming process, we provided them with guidance and resources for their research. We also supervised their lab work in the UCL Biochemical Engineering department.<br />
</p><br />
<p class="body_text"><br />
UCL is the first university in the UK to be the sole sponsor of an academy – a non-selective mixed state school in our home borough of Camden. UCL Academy represents a unique opportunity to blur the boundaries between secondary and higher education.<br />
</p><br />
<p class="body_text"><br />
The academy is one of the first UK high schools to participate in iGEM this year, and is the only UK team so far to have attended the <a href="https://2013hs.igem.org/Main_Page" target="_blank">High School iGEM Jamboree</a> at MIT, Boston. The team aimed to revolutionise the recycling industry by proposing a home system that converts cellulose into glucose, allowing the up-cycling of paper into a commercial product of bioplastic - polyhydroxybutyrate (PHB) <br />
</p><br />
</p><br />
<div class="small_image_right" style="background-image:url('https://static.igem.org/mediawiki/2013/b/b0/IMG_4769-1024x68211.jpg');height:280px;width:650px;"><br />
</div><br />
</p><br />
<p class="body_text"><br />
For information about their iGEM project, check out their wiki <a href="https://2013hs.igem.org/Team:UCL_Academy" target="_blank">here</a>. <br />
</p><br />
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</html></div>21Robin12http://2013.igem.org/Team:Westminster/ModellingTeam:Westminster/Modelling2013-10-05T03:15:48Z<p>21Robin12: </p>
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UCL Model Collaboration<br />
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<p><br />
Our project did not contain internal model generation, instead we received a model from the UCL iGEM team. The model simulated bed bugs moving randomly in a cubic room. One of our proposed blood traps was integrated into the simulation, which visually demonstrated bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<p><br />
Below this animation are a couple of graphs demonstrating the potential uses of the model. The first shows the approach of a single bedbug to the device; note the random fluctuation in addition to the directional motion. The second graph shows the effect of room size on time taken for all bedbugs to reach the device and die.<br />
<p><br />
The main collaboration for the Westminster project was with the UCL undergraduate team. The partnership was very beneficial to us and the UCL team were very helpful in enhancing our project!!<br />
</p><br />
<p><br />
The robust model allowed us to see how effective our device could be if it were to be developed as a real product, which is a very exciting prospect to consider that our project could be taken forward.<br />
</p><br />
<p><br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Westminster">Click here to visit the UCL iGEM collaboration page</a><br />
</p><br />
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<br />
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{{:Team:Westminster/template/footer}}</div>21Robin12http://2013.igem.org/Team:UCL/Modeling/WestminsterTeam:UCL/Modeling/Westminster2013-10-05T03:14:50Z<p>21Robin12: </p>
<hr />
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<br />
<p class="major_title">WESTMINSTER MODELING COLLABORATION</p><br />
<p class="minor_title">Another model based on the UCL simulation</p><br />
<br />
<p class="body_text"><br />
Since Westminster's iGEM team had not produced a model of their own, and their project has several similarities to ours, we have constructed an additional model, also in C#, and sent this to Westminster's team for them to use. The model simulates bed bugs moving randomly in a cubic room. One of their proposed "blood traps" is integrated into the simulation, which visually demonstrates bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p class="body_text"><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<p class="body_text"><br />
Below this animation are a couple of graphs demonstrating the potential uses of the model. The first shows the approach of a single bedbug to the device; note the random fluctuation in addition to the directional motion. The second graph shows the effect of room size on time taken for all bedbugs to reach the device and die.<br />
</p><br />
<br />
<p class="body_text"><br />
<span class="plainlinks"><br />
<a href="https://2013.igem.org/Team:Westminster/Modelling" target="_blank"><br />
Click here to visit the Westminster iGEM collaboration page</a></span><br />
</p><br />
<br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
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<div style="margin-left:auto;margin-right:auto;height:463px;width:723px;background-image:url('https://static.igem.org/mediawiki/2013/f/f7/Westgraph1.png');"></div><br />
<br />
<div style="margin-left:auto;margin-right:auto;height:451px;width:698px;background-image:url('https://static.igem.org/mediawiki/2013/1/1d/Westgraph2.png');"></div><br />
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</body><br />
</html></div>21Robin12http://2013.igem.org/File:Westgraph2.pngFile:Westgraph2.png2013-10-05T03:12:53Z<p>21Robin12: uploaded a new version of &quot;File:Westgraph2.png&quot;</p>
<hr />
<div></div>21Robin12http://2013.igem.org/Team:UCL/Modeling/WestminsterTeam:UCL/Modeling/Westminster2013-10-05T03:12:20Z<p>21Robin12: </p>
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</div><br />
<br />
<div class="full_page"><br />
<br />
<p class="major_title">WESTMINSTER MODELING COLLABORATION</p><br />
<p class="minor_title">Another model based on the UCL simulation</p><br />
<br />
<p class="body_text"><br />
Since Westminster's iGEM team had not produced a model of their own, and their project has several similarities to ours, we have constructed an additional model, also in C#, and sent this to Westminster's team for them to use. The model simulates bed bugs moving randomly in a cubic room. One of their proposed "blood traps" is integrated into the simulation, which visually demonstrates bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p class="body_text"><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<br />
<p class="body_text"><br />
<span class="plainlinks"><br />
<a href="https://2013.igem.org/Team:Westminster/Modelling" target="_blank"><br />
Click here to visit the Westminster iGEM collaboration page</a></span><br />
</p><br />
<br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
<br />
<div style="margin-left:auto;margin-right:auto;height:463px;width:723px;background-image:url('https://static.igem.org/mediawiki/2013/f/f7/Westgraph1.png');"></div><br />
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<div style="margin-left:auto;margin-right:auto;height:451px;width:698px;background-image:url('https://static.igem.org/mediawiki/2013/1/1d/Westgraph2.png');"></div><br />
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<hr />
<div></div>21Robin12http://2013.igem.org/File:Westgraph1.pngFile:Westgraph1.png2013-10-05T03:10:10Z<p>21Robin12: </p>
<hr />
<div></div>21Robin12http://2013.igem.org/Team:Westminster/ModellingTeam:Westminster/Modelling2013-10-05T02:45:31Z<p>21Robin12: </p>
<hr />
<div>{{:Team:Westminster/template/header}}<br />
<html><br />
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</html><br />
<!-- *** DO NOT TOUCH STUFF ABOVE UNLESS YOU KNOW WHAT YOU ARE DOING! *** --><br />
<html><br />
<h style="font-size:200%;"><br />
UCL Model Collaboration<br />
</h><br />
<br><br><br />
<p><br />
Our project did not contain internal model generation, instead we received a model from the UCL iGEM team. The model simulated bed bugs moving randomly in a cubic room. One of our proposed blood traps was integrated into the simulation, which visually demonstrated bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<p><br />
The main collaboration for the Westminster project was with the UCL undergraduate team. The partnership was very beneficial to us and the UCL team were very helpful in enhancing our project!!<br />
</p><br />
<p><br />
The robust model allowed us to see how effective our device could be if it were to be developed as a real product, which is a very exciting prospect to consider that our project could be taken forward.<br />
</p><br />
<p><br />
<a href="https://2013.igem.org/Team:UCL/Modeling/Westminster">Click here to visit the UCL iGEM collaboration page</a><br />
</p><br />
<br />
<br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
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<br />
<!-- *** DO NOT TOUCH STUFF BELOW UNLESS YOU KNOW WHAT YOU ARE DOING! *** --><br />
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</html><br />
{{:Team:Westminster/template/footer}}</div>21Robin12http://2013.igem.org/Team:UCL/Modeling/WestminsterTeam:UCL/Modeling/Westminster2013-10-05T02:44:38Z<p>21Robin12: </p>
<hr />
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<!-- START CONTENT ----------------------------------------------------------------------------------------------------><br />
<div class="gap"><br />
</div><br />
<br />
<div class="full_page"><br />
<br />
<p class="major_title">WESTMINSTER MODELING COLLABORATION</p><br />
<p class="minor_title">Another model based on the UCL simulation</p><br />
<br />
<p class="body_text"><br />
Since Westminster's iGEM team had not produced a model of their own, and their project has several similarities to ours, we have constructed an additional model, also in C#, and sent this to Westminster's team for them to use. The model simulates bed bugs moving randomly in a cubic room. One of their proposed "blood traps" is integrated into the simulation, which visually demonstrates bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p class="body_text"><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<br />
<p class="body_text"><br />
<span class="plainlinks"><br />
<a href="https://2013.igem.org/Team:Westminster/Modelling" target="_blank"><br />
Click here to visit the Westminster iGEM collaboration page</a></span><br />
</p><br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
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</html></div>21Robin12http://2013.igem.org/Team:UCL/Modeling/WestminsterTeam:UCL/Modeling/Westminster2013-10-05T02:44:27Z<p>21Robin12: </p>
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<!-- START CONTENT ----------------------------------------------------------------------------------------------------><br />
<div class="gap"><br />
</div><br />
<br />
<div class="full_page"><br />
<br />
<p class="major_title">WESTMINSTER MODELING COLLABORATION</p><br />
<p class="minor_title">Another model based on the UCL simulation</p><br />
<br />
<p class="body_text"><br />
Since Westminster's iGEM team had not produced a model of their own, and their project has several similarities to ours, we have constructed an additional model, also in C#, and sent this to Westminster's team for them to use. The model simulates bed bugs moving randomly in a cubic room. One of their proposed "blood traps" is integrated into the simulation, which visually demonstrates bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p class="body_text"><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<p class="body_text"><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<p class="body_text"><br />
<span class="plainlinks"><br />
<a href="https://2013.igem.org/Team:Westminster/Modelling" target="_blank"><br />
Click here to visit the Westminster iGEM collaboration page</a></span><br />
</p><br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
<br />
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</html></div>21Robin12http://2013.igem.org/Team:UCL/Modeling/WestminsterTeam:UCL/Modeling/Westminster2013-10-05T02:44:12Z<p>21Robin12: </p>
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<!-- START CONTENT ----------------------------------------------------------------------------------------------------><br />
<div class="gap"><br />
</div><br />
<br />
<div class="full_page"><br />
<br />
<p class="major_title">WESTMINSTER MODELING COLLABORATION</p><br />
<p class="minor_title">Another model based on the UCL simulation</p><br />
<br />
<p class="body_text"><br />
Since Westminster's iGEM team had not produced a model of their own, and their project has several similarities to ours, we have constructed an additional model, also in C#, and sent this to Westminster's team for them to use. The model simulates bed bugs moving randomly in a cubic room. One of their proposed "blood traps" is integrated into the simulation, which visually demonstrates bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p class="body_text"><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<p class="body_text"><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<br />
<span class="plainlinks"><br />
<a href="https://2013.igem.org/Team:Westminster/Modelling" target="_blank"><br />
Click here to visit the Westminster iGEM collaboration page</a></span><br />
<br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
<br />
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<br />
<!-- END CONTENT ------------------------------------------------------------------------------------------------------><br />
</div><br />
<br />
</div><br />
<br />
<script type="text/javascript" src="https://2013.igem.org/Team:UCL/static/footer.js?action=raw&ctype=text/javascript"> <br />
</script><br />
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</body><br />
</html></div>21Robin12http://2013.igem.org/Team:UCL/Modeling/WestminsterTeam:UCL/Modeling/Westminster2013-10-05T02:39:44Z<p>21Robin12: </p>
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<!-- START CONTENT ----------------------------------------------------------------------------------------------------><br />
<div class="gap"><br />
</div><br />
<br />
<div class="full_page"><br />
<br />
<p class="major_title">WESTMINSTER MODELING COLLABORATION</p><br />
<p class="minor_title">Another model based on the UCL simulation</p><br />
<br />
<p class="body_text"><br />
Our project did not contain internal model generation, instead we received a model from the UCL iGEM team. The model simulated bed bugs moving randomly in a cubic room. One of our proposed blood traps was integrated into the simulation, which visually demonstrated bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p class="body_text"><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<p class="body_text"><br />
The main collaboration for the Westminster project was with the UCL undergraduate team. The partnership was very beneficial to us and the UCL team were very helpful in enhancing our project!!<br />
</p><br />
<p class="body_text"><br />
The robust model allowed us to see how effective our device could be if it were to be developed as a real product, which is a very exciting prospect to consider that our project could be taken forward.<br />
</p><br />
<br><br><br />
<br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
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</html></div>21Robin12http://2013.igem.org/Team:UCL/Modeling/WestminsterTeam:UCL/Modeling/Westminster2013-10-05T02:39:12Z<p>21Robin12: </p>
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<p class="major_title">WESTMINSTER MODELING COLLABORATION</p><br />
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Our project did not contain internal model generation, instead we received a model from the UCL iGEM team. The model simulated bed bugs moving randomly in a cubic room. One of our proposed blood traps was integrated into the simulation, which visually demonstrated bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p class="body_text"><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<p class="body_text"><br />
The main collaboration for the Westminster project was with the UCL undergraduate team. The partnership was very beneficial to us and the UCL team were very helpful in enhancing our project!!<br />
</p><br />
<p class="body_text"><br />
The robust model allowed us to see how effective our device could be if it were to be developed as a real product, which is a very exciting prospect to consider that our project could be taken forward.<br />
</p><br />
<br><br><br />
<br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
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<h style="font-size:200%;"><br />
UCL Model Collaboration<br />
</h><br />
<br><br><br />
<p><br />
Our project did not contain internal model generation, instead we received a model from the UCL iGEM team. The model simulated bed bugs moving randomly in a cubic room. One of our proposed blood traps was integrated into the simulation, which visually demonstrated bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<p><br />
The main collaboration for the Westminster project was with the UCL undergraduate team. The partnership was very beneficial to us and the UCL team were very helpful in enhancing our project!!<br />
</p><br />
<p><br />
The robust model allowed us to see how effective our device could be if it were to be developed as a real product, which is a very exciting prospect to consider that our project could be taken forward.<br />
</p><br />
<br><br><br />
<br />
<br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
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<hr />
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<html><br />
<h style="font-size:200%;"><br />
UCL Model Collaboration<br />
</h><br />
<br><br><br />
<p><br />
Our project did not contain internal model generation, instead we received a model from the UCL iGEM team. The model simulated bed bugs moving randomly in a cubic room. One of our proposed blood traps was integrated into the simulation, which visually demonstrated bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p><br />
This simulation was written in C#, in a similar manner to UCL's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<p><br />
The main collaboration for the Westminster project was with the UCL undergraduate team. The partnership was very beneficial to us and the UCL team were very helpful in enhancing our project!!<br />
</p><br />
<p><br />
The robust model allowed us to see how effective our device could be if it were to be developed as a real product, which is a very exciting prospect to consider that our project could be taken forward.<br />
</p><br />
<br><br><br />
<br />
<br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
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{{:Team:Westminster/template/footer}}</div>21Robin12http://2013.igem.org/Team:Westminster/ModellingTeam:Westminster/Modelling2013-10-05T02:33:30Z<p>21Robin12: </p>
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<h style="font-size:200%;"><br />
UCL Model Collaboration<br />
</h><br />
<br><br />
<p><br />
Our project did not contain internal model generation, instead we received a model from the UCL iGEM team. The model simulated bed bugs moving randomly in a cubic room. One of our proposed blood traps was integrated into the simulation, which visually demonstrated bed bugs being attracted and then subsequently killed by the device. <br />
</p><br />
<p><br />
This simulation was written in C#, in a similar manner to UCl's own model. The animation below shows the model operating. Red dots represent bedbugs; as they move to the bottom-left hand corner of the floor, they are killed and removed from the model.<br />
</p><br />
<p><br />
The main collaboration for the Westminster project was with the UCL undergraduate team. The partnership was very beneficial to us and the UCL team were very helpful in enhancing our project!!<br />
</p><br />
<p><br />
The robust model allowed us to see how effective our device could be if it were to be developed as a real product, which is a very exciting prospect to consider that our project could be taken forward.<br />
</p><br />
<br><br><br />
<br />
<br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
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{{:Team:Westminster/template/footer}}</div>21Robin12http://2013.igem.org/Team:Westminster/ModellingTeam:Westminster/Modelling2013-10-05T02:31:27Z<p>21Robin12: </p>
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<h style="font-size:200%;"><br />
UCL Model Collaboration<br />
</h><br />
<p><br />
Our project did not contain internal model generation, instead we received a model from the UCL iGEM team. The model simulated bed bugs moving randomly in a bedspace. One of our proposed blood traps was integrated into the simulation, which visually demonstrated bed bugs being attracted and then subsequently killed by the device.<br />
</p><br />
<p><br />
The main collaboration for the Westminster project was with the UCL undergraduate team. The partnership was very beneficial to us and the UCL team were very helpful in enhancing our project!!<br />
</p><br />
<p><br />
The robust model allowed us to see how effective our device could be if it were to be developed as a real product, which is a very exciting prospect to consider that our project could be taken forward.<br />
</p><br />
<br />
<br />
<div style="margin-left:auto;margin-right:auto;height:783px;width:940px;background-image:url('https://static.igem.org/mediawiki/2013/b/b1/Bedbug_gif.gif');"></div><br />
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{{:Team:Westminster/template/footer}}</div>21Robin12http://2013.igem.org/Team:Westminster/ModellingTeam:Westminster/Modelling2013-10-05T02:30:51Z<p>21Robin12: </p>
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<!-- *** DO NOT TOUCH STUFF ABOVE UNLESS YOU KNOW WHAT YOU ARE DOING! *** --><br />
<html><br />
<h><br />
UCL Model Collaboration<br />
</h><br />
<p><br />
Our project did not contain internal model generation, instead we received a model from the UCL iGEM team. The model simulated bed bugs moving randomly in a bedspace. One of our proposed blood traps was integrated into the simulation, which visually demonstrated bed bugs being attracted and then subsequently killed by the device.<br />
</p><br />
<p><br />
The main collaboration for the Westminster project was with the UCL undergraduate team. The partnership was very beneficial to us and the UCL team were very helpful in enhancing our project!!<br />
</p><br />
<p><br />
The robust model allowed us to see how effective our device could be if it were to be developed as a real product, which is a very exciting prospect to consider that our project could be taken forward.<br />
</p><br />
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{{:Team:Westminster/template/footer}}</div>21Robin12http://2013.igem.org/File:Bedbug_gif.gifFile:Bedbug gif.gif2013-10-05T02:26:11Z<p>21Robin12: </p>
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<div></div>21Robin12http://2013.igem.org/Team:UCL/Modeling/OverviewTeam:UCL/Modeling/Overview2013-10-05T02:17:06Z<p>21Robin12: </p>
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<br />
<p class="major_title">WHAT IS A MODEL?</p><br />
<p class="minor_title">And how can it be used?</p><br />
<p class="body_text"><br />
Mathematical modelling provides a powerful tool for scientists of all disciplines, allowing inspection and manipulation of a system in ways which are unachievable in the lab. In the context of biology, we can use mathematical models to study the behaviour of a single cell or an entire ecosystem. In fact, inspecting a mathematical model is very much like a laboratory experiment – the main difference being that in modelling, the environment is artificial.<br />
</p><br />
<p class="body_text"><br />
To the right is a short animation showing the model’s graphical output. <b>Red dots represent amyloid plaques, and blue dots show microglia cells.</b> The red circle shows the boundary of a small hypothetical spherical section of the brain. Although the underlying mechanics of this animation are simply mathematical, the behaviour of the plaques and cells is surprisingly representative of the truth. This is the essence of a model.<br />
</p><br />
<br />
<p class="minor_title">UCL's iGEM model</p><br />
<br />
<p class="body_text"><br />
<span class="plainlinks"><br />
<a href="https://github.com/21robin12/ucligemmodel" target="_blank">The entire downloadable source code for the UCL model can be found on github. Click here, then download and compile the project to play with the iGEM model.</a></span><br><br><br />
When coupled with computational power, we can use mathematical modelling to produce intricate simulations of a very fine scale. This is exactly what the iGEM team has done this year, in producing a comprehensive model of the plaques and microglia in the brain. With many millions of cells present, mathematical tricks and techniques have been employed in order to allow computation of this highly complex system. For the end-user, this scaffolding is hidden from view: the final result will be a user-friendly windows application. <br />
</p><br />
<p class="body_text"><br />
The user-interface of the application is shown below. This interface hints at the internal operation of the model: a large number of numerical inputs are processed in a way representing the biological mechanics of the system, generating a set of numerical outputs. For example, these outputs could be the coordinates of a single microglia cell with corresponding time values, providing insight into how these cells move. Since almost every numerical factor can be altered by the user, the model can also be used to predict how a particular change would affect the system at large. <br />
</p><br />
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<br />
<p class="minor_title">Method Overview</p><br />
<p class="body_text"><br />
The brain is modelled as a 3D homogenous static medium, throughout which small ‘plaques’ are fixed. As far as the model is concerned, these plaques cause Alzheimer’s, and their removal would result in the reversal of the disease’s effects. At the start of the model (t=0), a number of microglia cells will be introduced to the system at a number of distinct points. These will then move throughout the brain, will the overall goal of binding to and removing the plaques. <br />
</p><br />
<p class="body_text"><br />
Every plaque and microglia cell is modelled individually, with the state of the system regularly sampled (roughly every minute). In between samplings, a number of processes take place. The diagram to the right outlines these processes.<br />
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<br />
<p class="major_title">WHAT IS A MODEL?</p><br />
<p class="minor_title">And how can it be used?</p><br />
<p class="body_text"><br />
Mathematical modelling provides a powerful tool for scientists of all disciplines, allowing inspection and manipulation of a system in ways which are unachievable in the lab. In the context of biology, we can use mathematical models to study the behaviour of a single cell or an entire ecosystem. In fact, inspecting a mathematical model is very much like a laboratory experiment – the main difference being that in modelling, the environment is artificial.<br />
</p><br />
<p class="body_text"><br />
To the right is a short animation showing the model’s graphical output. <b>Red dots represent amyloid plaques, and blue dots show microglia cells.</b> The red circle shows the boundary of a small hypothetical spherical section of the brain. Although the underlying mechanics of this animation are simply mathematical, the behaviour of the plaques and cells is surprisingly representative of the truth. This is the essence of a model.<br />
</p><br />
<br />
<p class="minor_title">UCL's iGEM model</p><br />
<br />
<p class="body_text"><br />
<a href="https://github.com/21robin12/ucligemmodel" target="_blank">The entire downloadable source code for the UCL model can be found on github. Click here, then download and compile the project to play with the iGEM model.</a><br><br><br />
When coupled with computational power, we can use mathematical modelling to produce intricate simulations of a very fine scale. This is exactly what the iGEM team has done this year, in producing a comprehensive model of the plaques and microglia in the brain. With many millions of cells present, mathematical tricks and techniques have been employed in order to allow computation of this highly complex system. For the end-user, this scaffolding is hidden from view: the final result will be a user-friendly windows application. <br />
</p><br />
<p class="body_text"><br />
The user-interface of the application is shown below. This interface hints at the internal operation of the model: a large number of numerical inputs are processed in a way representing the biological mechanics of the system, generating a set of numerical outputs. For example, these outputs could be the coordinates of a single microglia cell with corresponding time values, providing insight into how these cells move. Since almost every numerical factor can be altered by the user, the model can also be used to predict how a particular change would affect the system at large. <br />
</p><br />
<br />
<div class="gap"><br />
</div><br />
<div class="image_middle" style="background-image:url('https://static.igem.org/mediawiki/2013/7/76/Interface.png');width:976px;height:543px;"></div><br />
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<br />
<p class="minor_title">Method Overview</p><br />
<p class="body_text"><br />
The brain is modelled as a 3D homogenous static medium, throughout which small ‘plaques’ are fixed. As far as the model is concerned, these plaques cause Alzheimer’s, and their removal would result in the reversal of the disease’s effects. At the start of the model (t=0), a number of microglia cells will be introduced to the system at a number of distinct points. These will then move throughout the brain, will the overall goal of binding to and removing the plaques. <br />
</p><br />
<p class="body_text"><br />
Every plaque and microglia cell is modelled individually, with the state of the system regularly sampled (roughly every minute). In between samplings, a number of processes take place. The diagram to the right outlines these processes.<br />
</p><br />
<br />
<div class="gap"><br />
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Lorem ipsum dolor sit amet, consectetur adipiscing elit. Vivamus vel fringilla diam. Integer placerat sapien sed risus mollis, eget hendrerit lorem tincidunt. Cras a sem eros. Ut nec ligula eget tortor ornare tempus sit amet quis risus. Quisque condimentum, ipsum ac rhoncus ornare, tellus augue imperdiet libero, in venenatis justo arcu quis tellus. Vivamus magna libero, tempus ac augue at, placerat vulputate nunc. Praesent fringilla id erat ut sagittis. Sed nec semper risus, nec condimentum leo. Vestibulum pharetra pellentesque augue, non ultrices leo varius et. Vestibulum id egestas orci. Vestibulum metus ipsum, iaculis nec sapien in, fringilla cursus orci. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Curabitur eget vulputate ligula. Sed venenatis nulla et porta pharetra. Suspendisse pharetra suscipit justo sagittis consequat. Morbi eu iaculis diam, ac rhoncus urna. Pellentesque eros ligula, mollis vitae metus sit amet, interdum gravida nunc. Duis tempor quam id rhoncus sodales. Nunc commodo accumsan orci ut faucibus. Quisque vitae luctus libero. Nullam risus libero, convallis et viverra sit amet, convallis a neque. Integer adipiscing ac arcu sit amet luctus. In dignissim mauris non justo tempor, in rhoncus augue volutpat. Duis euismod sodales blandit. Vivamus volutpat molestie dignissim. Quisque cursus quam cursus dui faucibus convallis. Praesent dignissim, sem ut posuere accumsan, libero diam consequat libero, vel tempor dui mi sed massa. Aenean eros arcu, sollicitudin a euismod eu, placerat vel nunc. Nunc consequat blandit fermentum. Curabitur ante erat, lobortis ac faucibus a, sollicitudin egestas nisi. Morbi ut dolor scelerisque, fermentum est vitae, commodo tortor. Vestibulum ornare semper lorem vel volutpat. In erat ligula, auctor eu pellentesque vitae, sollicitudin id sapien. Duis pharetra sagittis purus hendrerit pharetra. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Vivamus elementum iaculis neque nec fringilla. Nunc a scelerisque nulla, et varius massa. In eu pretium eros. Quisque nec lacus elit. Mauris malesuada luctus dapibus. Vivamus eget ultricies sem. Quisque nulla tellus, euismod vel vehicula adipiscing, ornare sit amet dui. Sed eget mauris aliquam, feugiat diam vel, lacinia nunc. Ut vel est facilisis, dictum sem sit amet, lobortis arcu. In hac habitasse platea dictumst. Fusce ut accumsan sapien. Sed pharetra ullamcorper dolor vitae rutrum. Aliquam luctus mattis felis vitae semper. Vivamus id sodales purus. Cras quis quam non tortor tincidunt laoreet varius suscipit lectus. Curabitur faucibus et libero quis vulputate. Nunc sed gravida libero. Phasellus eleifend, metus mattis molestie luctus, augue libero lacinia massa, ac volutpat tortor tortor quis sapien. Donec ultrices felis ut arcu rutrum sollicitudin. Praesent nec ligula at risus hendrerit aliquam. Etiam vestibulum aliquam ultricies. Ut semper libero volutpat, rutrum enim et, eleifend nibh. Nulla ornare, elit sed laoreet condimentum, quam nunc auctor sem, eu commodo elit ante id magna. <br />
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What were the skies like when you were young?<br />
</p><br />
<p class="abstract_text" style="color : #404040;"><br />
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They were beautiful, the most beautiful skies as a <br />
matter of fact. The sunsets were purple and red and <br />
yellow and on fire, and the clouds would catch the <br />
colours everywhere.<br />
<br />
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<br>Click to learn more.<br />
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One of the main symptoms of Alzheimer's Disease is the loss of memory.<br />
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Eternal Sunshine is an online vault where a special memory can be stored. Upload an image along with a short message to add your memory to the vault, or scroll down to see uploaded memories.<br />
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Click to upload your memory to Eternal Sunshine.<br />
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It's been a good journey thus far with StJohn's expertise in primer design. I will always remember the special bond in the form of Facebook messages consisting of DNA codes and scientific papers. Wishing StJohn a wonderful year in Montreal!<br />
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The memories of family holidays when you are young are such a mix of emotive events. Stress, arguments, adventure, taking in the wondrous sights of a new place... For me, they are the best of memories, because they distil the essence of what family is and inspire a love for travel.<br />
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I am not religious, but there is something awe inspiring about cathedrals. I suppose that's the point. I've visited many, and treasure these memories because they are a safe place to retreat to when things in the present get hectic.<br />
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This is me and some incredible young people I had the pleasure of teaching for a week at a summer camp in Romania. For me, the whole experience is a reminder of how many good people there are in the world, and how knowing people for such a short amount of time can still yield the richest memories and life-long friendships.<br />
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Going to Namibia and watching the elephants around the waterhole at sunset. They were the most beautiful animals I had ever seen. I hope I never forget this image.<br />
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This is a picture that evokes one of the best days of my life. To me its pictorial form represents a day that will never be replicated and perhaps even an era that has come to pass.<br />
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Visiting America and seeing amazing places like NYC with my best friend who I met online. Amazing in every way, from exploring, to knowing that there are no barriers to meeting fantastic people who can bring happiness into our life.<br />
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This is a photo of me and my grandparents from when I was little. As a child,I used to spend my summer holiday at my grandparents and those moments were the best moments of my life, the single time when I was truly happy day after day. I've never been as happy as then. Certainly I don't want to forget these memories! I want to keep those memories alive as well as my grandfather's image,who passed away a long time ago. Hope I will be able to cherish my childhood memories till my dying day.<br />
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Memories are whey are because of the people you share them with<br />
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This is my favourite object. Its special because it reminds me of personal discovery and surprise, and how surprises occur constantly, even in old environments.<br />
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This was the beginning of my time at uni. It was my first week with people who would become great friends. I've loved my time at uni and this photo reminds me of some the amazing times I have had there.<br />
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There is something mesmerizing about this place; I felt free and honored to be able to witness it.<br />
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Going home from hospital with my two lovely babies and my wonderful husband.<br />
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A time when life was fun, frivolous and uncomplicated!<br />
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Perfect day celebrating birthday and public holiday with friends and family in a gorgeous setting and the knowledge that I was newly pregnant with my son!<br />
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There's a cliff thats particularly soft and green. Underneath there's dark slate shattered everywhere and its nosey and dangerous, but when you lie down its silent, and the softness of the moss muffles everything so all you can see is the sky- even the wind just misses your face. Its the perfect place to just be.<br />
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It represents ambition, the past and the future.<br />
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The perpetual cocktail party.<br />
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The annual bonfire night gathering. The air was always so cold and crisp and nipped at our rosy little cheeks<br />
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<p class="major_title">SIMULATION DATA</p><br />
<p class="minor_title">The power of modeling</p><br />
<p class="body_text"><br />
For all the complex calculations and mechanisms behind a model, it is without much worth if it cannot produce useful results. In general, 'useful results' are defined as successful predictions about the effects of modifying some parameter - if we can use a model to determine the effect of each variable upon the outcome, we can better design our system in the real world.<br />
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The results on this page represent a tiny fraction of the power of our model. Since any variable can be inspected at any time during the simulation, we can generate tables of data for any aspect of the model. Here, we provide a few examples of data output from our model. <br />
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<p class="minor_title">Signal concentration throughout the brain after one simulation</p><br />
<p class="body_text"><br />
In the image to the right is a diagram of a 2cm diameter spherical section of the brain, showing both signal concentrations once the simulation has finished. Red indicates a high concentration and green a low concentration. Signals are found in higher concentrations where more plaques are located, since the signals are only secreted once a threshold level of oxidative stress is reached. Notice that MMP-9 concentrations are higher than IP-10 concentrations - this is to be expected since the threshold oxidative stress level for MMP-9 is lower than that for IP-10.<br />
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These images were generated by firstly writing signal concentration data to a spreadsheet, then taking the logarithm of these values (since signal concentration varies greatly), and finally by colour-coding these values accordingly.<br />
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<p class="minor_title">Microglia effectiveness</p><br />
<p class="body_text"><br />
Since the entire project is concerned with the clearing of amyloid plaques, the main useful result from the model is the effect of changing each variable upon the ability of microglia to locate and degrade these plaques. Below are three graphs showing this. In the simulations behind these graphs, a number of microglia were introduced into the system at the same location, and the time taken for 50% of the plaques within a 10mm radius to be removed was measured. <br />
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<div></div>21Robin12http://2013.igem.org/File:Graph1.pngFile:Graph1.png2013-10-05T01:15:18Z<p>21Robin12: </p>
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<p class="major_title">SIMULATION DATA</p><br />
<p class="minor_title">The power of modeling</p><br />
<p class="body_text"><br />
For all the complex calculations and mechanisms behind a model, it is without much worth if it cannot produce useful results. In general, 'useful results' are defined as successful predictions about the effects of modifying some parameter - if we can use a model to determine the effect of each variable upon the outcome, we can better design our system in the real world.<br />
</p><br />
<p class="body_text"><br />
The results on this page represent a tiny fraction of the power of our model. Since any variable can be inspected at any time during the simulation, we can generate tables of data for any aspect of the model. Here, we provide a few examples of data output from our model. <br />
</p><br />
<p class="minor_title">Signal concentration throughout the brain after one simulation</p><br />
<p class="body_text"><br />
In the image to the right is a diagram of a 2cm diameter spherical section of the brain, showing both signal concentrations once the simulation has finished. Red indicates a high concentration and green a low concentration. Signals are found in higher concentrations where more plaques are located, since the signals are only secreted once a threshold level of oxidative stress is reached. Notice that MMP-9 concentrations are higher than IP-10 concentrations - this is to be expected since the threshold oxidative stress level for MMP-9 is lower than that for IP-10.<br />
</p><br />
<p class="body_text"><br />
These images were generated by firstly writing signal concentration data to a spreadsheet, then taking the logarithm of these values (since signal concentration varies greatly), and finally by colour-coding these values accordingly.<br />
</p><br />
<br />
<p class="minor_title">Microglia effectiveness</p><br />
<p class="body_text"><br />
Since the entire project is concerned with the clearing of amyloid plaques, the main useful result from the model is the effect of changing each variable upon the ability of microglia to locate and degrade these plaques. Below are three graphs showing this. In the simulations behind these graphs, a number of microglia were introduced into the system at the same location, and the time taken for 50% of the plaques within a 10mm radius to be removed was measured. <br />
</p><br />
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<p class="major_title">SIMULATION DATA</p><br />
<p class="minor_title">The power of modeling</p><br />
<p class="body_text"><br />
For all the complex calculations and mechanisms behind a model, it is without much worth if it cannot produce useful results. In general, 'useful results' are defined as successful predictions about the effects of modifying some parameter - if we can use a model to determine the effect of each variable upon the outcome, we can better design our system in the real world.<br />
</p><br />
<p class="body_text"><br />
The results on this page represent a tiny fraction of the power of our model. Since any variable can be inspected at any time during the simulation, we can generate tables of data for any aspect of the model. Here, we provide a few examples of data output from our model. <br />
</p><br />
<p class="minor_title">Signal concentration throughout the brain after one simulation</p><br />
<p class="body_text"><br />
In the image to the right is a diagram of a 2cm diameter spherical section of the brain, showing both signal concentrations once the simulation has finished. Red indicates a high concentration and green a low concentration. Signals are found in higher concentrations where more plaques are located, since the signals are only secreted once a threshold level of oxidative stress is reached. Notice that MMP-9 concentrations are higher than IP-10 concentrations - this is to be expected since the threshold oxidative stress level for MMP-9 is lower than that for IP-10.<br />
</p><br />
<p class="body_text"><br />
These images were generated by firstly writing signal concentration data to a spreadsheet, then taking the logarithm of these values (since signal concentration varies greatly), and finally by colour-coding these values accordingly.<br />
</p><br />
<br />
<p class="minor_title">Microglia effectiveness</p><br />
<p class="body_text"><br />
Since the entire project is concerned with the clearing of amyloid plaques, the main useful result from the model is the effect of changing each variable upon the ability of microglia to locate and degrade these plaques. Below are three graphs showing this. In the simulations behind these graphs, a number of microglia were introduced into the system at the same location, and the time taken for 50% of the plaques within a 10mm radius to be removed was measured. <br />
</p><br />
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<p class="major_title">SIMULATION DATA</p><br />
<p class="minor_title">The power of modeling</p><br />
<p class="body_text"><br />
For all the complex calculations and mechanisms behind a model, it is without much worth if it cannot produce useful results. In general, 'useful results' are defined as successful predictions about the effects of modifying some parameter - if we can use a model to determine the effect of each variable upon the outcome, we can better design our system in the real world.<br />
</p><br />
<p class="body_text"><br />
The results on this page represent a tiny fraction of the power of our model. Since any variable can be inspected at any time during the simulation, we can generate tables of data for any aspect of the model. Here, we provide a few examples of data output from our model. <br />
</p><br />
<p class="minor_title">Signal concentration throughout the brain after one simulation</p><br />
<p class="body_text"><br />
In the image to the right is a diagram of a 2cm diameter spherical section of the brain, showing both signal concentrations once the simulation has finished. Red indicates a high concentration and green a low concentration. Signals are found in higher concentrations where more plaques are located, since the signals are only secreted once a threshold level of oxidative stress is reached. Notice that MMP-9 concentrations are higher than IP-10 concentrations - this is to be expected since the threshold oxidative stress level for MMP-9 is lower than that for IP-10.<br />
</p><br />
<p class="body_text"><br />
These images were generated by firstly writing signal concentration data to a spreadsheet, then taking the logarithm of these values (since signal concentration varies greatly), and finally by colour-coding these values accordingly.<br />
</p><br />
<br />
<p class="minor_title">Microglia effectiveness</p><br />
<p class="body_text"><br />
Since the entire project is concerned with the clearing of amyloid plaques, the main useful result from the model is the effect of changing each variable upon the ability of microglia to locate and degrade these plaques. Below are three graphs showing this. In the simulations behind these graphs, a number of microglia were introduced into the system at the same location, and the time taken for 50% of the plaques within a 10mm radius to be removed was measured. <br />
</p><br />
<br />
<br />
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<p class="major_title">SIMULATION DATA</p><br />
<p class="minor_title">The power of modeling</p><br />
<p class="body_text"><br />
For all the complex calculations and mechanisms behind a model, it is without much worth if it cannot produce useful results. In general, 'useful results' are defined as successful predictions about the effects of modifying some parameter - if we can use a model to determine the effect of each variable upon the outcome, we can better design our system in the real world.<br />
</p><br />
<p class="body_text"><br />
The results on this page represent a tiny fraction of the power of our model. Since any variable can be inspected at any time during the simulation, we can generate tables of data for any aspect of the model. Here, we provide a few examples of data output from our model. <br />
</p><br />
<p class="minor_title">Signal concentration throughout the brain after one simulation</p><br />
<p class="body_text"><br />
In the image to the right is a diagram of a 2cm diameter spherical section of the brain, showing both signal concentrations once the simulation has finished. Red indicates a high concentration and green a low concentration. Signals are found in higher concentrations where more plaques are located, since the signals are only secreted once a threshold level of oxidative stress is reached. Notice that MMP-9 concentrations are higher than IP-10 concentrations - this is to be expected since the threshold oxidative stress level for MMP-9 is lower than that for IP-10.<br />
</p><br />
<p class="body_text"><br />
These images were generated by firstly writing signal concentration data to a spreadsheet, then taking the logarithm of these values (since signal concentration varies greatly), and finally by colour-coding these values accordingly.<br />
</p><br />
<br />
<p class="minor_title">Microglia effectiveness</p><br />
<p class="body_text"><br />
Since the entire project is concerned with the clearing of amyloid plaques, the main useful result from the model is the effect of changing each variable upon the ability of microglia to locate and degrade these plaques. Below are three graphs showing this. In the simulations behind these graphs, a number of microglia were introduced into the system at the same location, and the time taken for 50% of the plaques within a 10mm radius to be removed was measured. <br />
</p><br />
<br />
<br />
<div class="image_middle" style="height:659px;background-image:url('#');" ></div><br />
<div class="image_middle" style="height:658px;background-image:url('#');" ></div><br />
<div class="image_middle" style="height:656px;background-image:url('#');" ></div><br />
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