Team:ATOMS-Turkiye/Project/Module2

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This module is continuation of module 1 and the module mainly consists of specific tumor killer proteins which are expected to decrease cancer cell proliferation and to induce apoptosis. We have two specific apoptotic proteins called Apoptin and E4orf4. In our project plan, engineered bacteria secrete these proteins and these tumor killers penetrate into cancer cells to induce apoptosis within the cells. Through cancer cell penetration, cell penetrating peptides called TAT (Transactivating Transcription peptide) and MPG (designed cell penetrating peptide) have critical roles. Cell penetrating peptides fused with Apoptin and E4orf4 selectively kill tumor cells while normal cells remain undamaged. This  point of view takes the advantage of synthetic biology and implies a new targeted therapeutic approach in future.  
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This module mainly consists of specific proteins secreted by our enginereed bacteria which act as a targeted tumor killer. Our choice of killer proteins are E4of4 and apoptin. Following bacterial secretion, spesific proteins penetrate into cancer cells and induce apoptosis within them. Recent studies have shown that the cancer specific proteins Apoptin and E4of4 have the ability of inducing apoptosis once inside a cancer cell. At this point, tumor specificity  is very crucial as it has the potential of damaging healthy cells during the contemporary cancer treatment. MPG and TAT were our choice of peptides which are capable of penetrating cancer cells together with Apoptin and E4of4; therefore decreasing the cancer populations rate of growth.
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Latest revision as of 15:31, 19 May 2014

Overview

This module mainly consists of specific proteins secreted by our enginereed bacteria which act as a targeted tumor killer. Our choice of killer proteins are E4of4 and apoptin. Following bacterial secretion, spesific proteins penetrate into cancer cells and induce apoptosis within them. Recent studies have shown that the cancer specific proteins Apoptin and E4of4 have the ability of inducing apoptosis once inside a cancer cell. At this point, tumor specificity is very crucial as it has the potential of damaging healthy cells during the contemporary cancer treatment. MPG and TAT were our choice of peptides which are capable of penetrating cancer cells together with Apoptin and E4of4; therefore decreasing the cancer populations rate of growth.

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