Team:Concordia/Modeling

From 2013.igem.org

(Difference between revisions)
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<div class="container">
<div class="container">
-
  <div class="allContainer">
+
 
-
    <div class="title">
+
    <div class="allContainer">
-
      <h1 class='text-right'>Numerical Analysis of Gene Regulatory Network Protein Synthesis and Decay</h1>
+
      <div class="title">
-
    </div>
+
        <img src="img/logo.png" alt="logo"/>
-
    <h3 class="parameters-label section-expand">+ Parameters</h3 >
+
        <h1 class='text-right'>Numerical Analysis of Gene Regulatory Network Protein Synthesis and Decay</h1>
-
    <div class="all-parameters" style='display:none;'>
+
      </div>
-
      <div class="parameter-section-row">
+
      <h3 class="parameters-label section-expand">+ Parameters</h3 >
-
        <!-- Gas -->
+
      <div class="all-parameters" style='display:none;'>
-
        <div class="parameter-section">
+
          <div class="parameter-section-row">
-
          <p class="section-collapse">&#45; Gas Protein synthesis parameters</p>
+
          <!-- Gas -->
-
          <div class='parameter-control-container'>
+
          <div class="parameter-section">
-
            <div class='parameter-control'>
+
            <p class="section-collapse">&#45; Gas Protein synthesis parameters</p>
-
              <span class="parameter-control-label">Half-life:</span>
+
            <div class='parameter-control-container'>
-
              <div class="input-group">
+
              <div class='parameter-control'>
-
                <input id="GasProteinHalfLifeInput" type="text" class="form-control" placeholder="20"> </input><span class="input-group-addon">units</span>
+
                <span class="parameter-control-label">Half-life:</span>
 +
                <div class="input-group">
 +
                  <input id="GasProteinHalfLifeInput" type="text" class="form-control" placeholder="20"> </input><span class="input-group-addon">units</span>
 +
                </div>
               </div>
               </div>
-
            </div>
+
              <div class='parameter-control'>
-
            <div class='parameter-control'>
+
                <span class="parameter-control-label">Promoter Strength:</span>
-
              <span class="parameter-control-label">Promoter Strength:</span>
+
                <div class="input-group">
-
              <div class="input-group">
+
                 <input id="GasProteinStrengthInput" type="text" class="form-control" placeholder="1"> </input><span class="input-group-addon">units</span>
                 <input id="GasProteinStrengthInput" type="text" class="form-control" placeholder="1"> </input><span class="input-group-addon">units</span>
 +
                </div>
               </div>
               </div>
-
            </div>
+
              <div class='parameter-control'>
-
            <div class='parameter-control'>
+
                <span class="parameter-control-label">Protein Size Factor:</span>
-
              <span class="parameter-control-label">Protein Size Factor:</span>
+
                <div class="input-group">
-
              <div class="input-group">
+
                 <input id="GasProteinSizeInput" type="text" class="form-control" placeholder="4"> </input><span class="input-group-addon">units</span>
                 <input id="GasProteinSizeInput" type="text" class="form-control" placeholder="4"> </input><span class="input-group-addon">units</span>
 +
                </div>
               </div>
               </div>
-
            </div>
+
              <div class='parameter-control'>
-
            <div class='parameter-control'>
+
                <span class="parameter-control-label">Turn-off threshold:</span>
-
              <span class="parameter-control-label">Turn-off threshold:</span>
+
                <div class="input-group">
-
              <div class="input-group">
+
                 <input id="GasProteinThresholdInput" type="text" class="form-control" placeholder="25"> </input><span class="input-group-addon">units</span>
                 <input id="GasProteinThresholdInput" type="text" class="form-control" placeholder="25"> </input><span class="input-group-addon">units</span>
 +
                </div>
               </div>
               </div>
-
            </div>
+
              <div class='parameter-control'>
-
            <div class='parameter-control'>
+
                <span class="parameter-control-label">Turn-off sensitivity:</span>
-
              <span class="parameter-control-label">Turn-off sensitivity:</span>
+
                <div class="input-group">
-
              <div class="input-group">
+
                 <input id="GasProteinSensitivityInput" type="text" class="form-control" placeholder="3"> </input><span class="input-group-addon">units</span>
                 <input id="GasProteinSensitivityInput" type="text" class="form-control" placeholder="3"> </input><span class="input-group-addon">units</span>
 +
                </div>
               </div>
               </div>
-
            </div>
+
              <li class="divider"></li>
-
            <li class="divider"></li>
+
              <div class='parameter-control'>
-
            <div class='parameter-control'>
+
                <span class="parameter-control-label">Gas Prod factor:</span>
-
              <span class="parameter-control-label">Gas Prod factor:</span>
+
                <div class="input-group">
-
              <div class="input-group">
+
                 <input id="GasProductionInput" type="text" class="form-control" placeholder="1"> </input><span class="input-group-addon">units</span>
                 <input id="GasProductionInput" type="text" class="form-control" placeholder="1"> </input><span class="input-group-addon">units</span>
 +
                </div>
               </div>
               </div>
-
            </div>
+
              <div class='parameter-control'>
-
            <div class='parameter-control'>
+
                <span class="parameter-control-label">Gas Diffusion rates:</span>
-
              <span class="parameter-control-label">Gas Diffusion rates:</span>
+
                <div class="input-group">
-
              <div class="input-group">
+
                 <input id="GasDiffusionInput" type="text" class="form-control" placeholder="39.5"> </input><span class="input-group-addon">units</span>
                 <input id="GasDiffusionInput" type="text" class="form-control" placeholder="39.5"> </input><span class="input-group-addon">units</span>
 +
                </div>
 +
              </div>
 +
              <div class='parameter-control'>
 +
                <button id="bttnGraphGasRate" type="button" class="btn btn-default">Graph</button>
 +
              </div>
 +
              <div class='graph-container'>
 +
                <p class="section-collapse"> &#45; Rate of gas as a function of Gas Protein</p>
 +
                <div  id='gas-rate-graph' class='rate-graph'>
 +
                </div>
 +
                <p class="section-collapse"> &#45; Rate of Gas Protein as a function of Repressor</p>
 +
                <div  id='gas-protein-rate-graph' class='rate-graph'>
 +
                </div>
               </div>
               </div>
             </div>
             </div>
-
            <div class='parameter-control'>
+
          </div>
-
              <button id="bttnGraphGasRate" type="button" class="btn btn-default">Graph</button>
+
          <!-- Repressor -->
-
             </div>
+
          <div class="parameter-section">
-
            <div class='graph-container'>
+
            <p class="section-collapse">&#45; Repressor synthesis parameters</p>
-
              <p class="section-collapse"> &#45; Rate of gas as a function of Gas Protein</p>
+
             <div class='parameter-control-container'>
-
              <div id='gas-rate-graph' class='rate-graph'>
+
              <div class='parameter-control'>
 +
                <span class="parameter-control-label">Half-life:</span>
 +
                <div class="input-group">
 +
                  <input id="RepressorHalfLifeInput" type="text" class="form-control" placeholder="20"> </input><span class="input-group-addon">units</span>
 +
                </div>
               </div>
               </div>
-
               <p class="section-collapse"> &#45; Rate of Gas Protein as a function of Repressor</p>
+
               <div class='parameter-control'>
-
              <div  id='gas-protein-rate-graph' class='rate-graph'>
+
                <span class="parameter-control-label">Promoter Strength:</span>
 +
                <div class="input-group">
 +
                <input id="RepressorStrengthInput" type="text" class="form-control" placeholder="4"> </input><span class="input-group-addon">units</span>
 +
                </div>
 +
              </div>
 +
              <div class='parameter-control'>
 +
                <span class="parameter-control-label">Protein Size Factor:</span>
 +
                <div class="input-group">
 +
                <input id="RepressorSizeInput" type="text" class="form-control" placeholder="1"> </input><span class="input-group-addon">units</span>
 +
                </div>
 +
              </div>
 +
              <div class='parameter-control'>
 +
                <span class="parameter-control-label">Turn-off threshold:</span>
 +
                <div class="input-group">
 +
                <input id="RepressorThresholdInput" type="text" class="form-control" placeholder="25"> </input><span class="input-group-addon">units</span>
 +
                </div>
 +
              </div>
 +
              <div class='parameter-control'>
 +
                <span class="parameter-control-label">Turn-off sensitivity:</span>
 +
                <div class="input-group">
 +
                <input id="RepressorSensitivityInput" type="text" class="form-control" placeholder="3"> </input><span class="input-group-addon">units</span>
 +
                </div>
 +
              </div>
 +
              <div class='parameter-control'>
 +
                <button id="bttnGraphRepRate" type="button" class="btn btn-default">Graph</button>
 +
              </div>
 +
              <div class='graph-container'>
 +
                <p class="section-collapse"> &#45; Rate of Repressor as a function of Gas</p>
 +
                <div  id='rep-rate-graph' class='rate-graph'>
 +
                </div>
               </div>
               </div>
             </div>
             </div>
           </div>
           </div>
-
        </div>
+
          <!-- AHLR -->
-
        <!-- Repressor -->
+
          <div class="parameter-section">
-
        <div class="parameter-section">
+
           <p class="section-collapse"> &#45; AHLR synthesis parameters</p>
-
           <p class="section-collapse">&#45; Repressor synthesis parameters</p>
+
           <div class='parameter-control-container'>
           <div class='parameter-control-container'>
             <div class='parameter-control'>
             <div class='parameter-control'>
               <span class="parameter-control-label">Half-life:</span>
               <span class="parameter-control-label">Half-life:</span>
               <div class="input-group">
               <div class="input-group">
-
                 <input id="RepressorHalfLifeInput" type="text" class="form-control" placeholder="20"> </input><span class="input-group-addon">units</span>
+
                 <input id="AhlrHalfLifeInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
               </div>
               </div>
             </div>
             </div>
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               <span class="parameter-control-label">Promoter Strength:</span>
               <span class="parameter-control-label">Promoter Strength:</span>
               <div class="input-group">
               <div class="input-group">
-
                <input id="RepressorStrengthInput" type="text" class="form-control" placeholder="4"> </input><span class="input-group-addon">units</span>
+
              <input id="AhlrStrengthInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
               </div>
               </div>
             </div>
             </div>
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               <span class="parameter-control-label">Protein Size Factor:</span>
               <span class="parameter-control-label">Protein Size Factor:</span>
               <div class="input-group">
               <div class="input-group">
-
                <input id="RepressorSizeInput" type="text" class="form-control" placeholder="1"> </input><span class="input-group-addon">units</span>
+
              <input id="AhlrSizeInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
               </div>
               </div>
             </div>
             </div>
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               <span class="parameter-control-label">Turn-off threshold:</span>
               <span class="parameter-control-label">Turn-off threshold:</span>
               <div class="input-group">
               <div class="input-group">
-
                <input id="RepressorThresholdInput" type="text" class="form-control" placeholder="25"> </input><span class="input-group-addon">units</span>
+
              <input id="AhlrThresholdInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
               </div>
               </div>
             </div>
             </div>
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               <span class="parameter-control-label">Turn-off sensitivity:</span>
               <span class="parameter-control-label">Turn-off sensitivity:</span>
               <div class="input-group">
               <div class="input-group">
-
                <input id="RepressorSensitivityInput" type="text" class="form-control" placeholder="3"> </input><span class="input-group-addon">units</span>
+
              <input id="AhlrSensitivityInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
-
              </div>
+
-
            </div>
+
-
            <div class='parameter-control'>
+
-
              <button id="bttnGraphRepRate" type="button" class="btn btn-default">Graph</button>
+
-
            </div>
+
-
            <div class='graph-container'>
+
-
              <p class="section-collapse"> &#45; Rate of Repressor as a function of Gas</p>
+
-
              <div  id='rep-rate-graph' class='rate-graph'>
+
               </div>
               </div>
             </div>
             </div>
           </div>
           </div>
         </div>
         </div>
-
        <!-- AHLR -->
 
-
        <div class="parameter-section">
 
-
          <p class="section-collapse"> &#45; AHLR synthesis parameters</p>
 
-
          <div class='parameter-control-container'>
 
-
            <div class='parameter-control'>
 
-
      <span class="parameter-control-label">Half-life:</span>
 
-
      <div class="input-group">
 
-
                <input  id="AhlrHalfLifeInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
 
-
      </div>
 
-
            </div>
 
-
            <div class='parameter-control'>
 
-
      <span class="parameter-control-label">Promoter Strength:</span>
 
-
      <div class="input-group">
 
-
<input  id="AhlrStrengthInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
 
-
      </div>
 
-
            </div>
 
-
            <div class='parameter-control'>
 
-
      <span class="parameter-control-label">Protein Size Factor:</span>
 
-
      <div class="input-group">
 
-
<input id="AhlrSizeInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
 
-
      </div>
 
-
            </div>
 
-
            <div class='parameter-control'>
 
-
      <span class="parameter-control-label">Turn-off threshold:</span>
 
-
      <div class="input-group">
 
-
<input id="AhlrThresholdInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
 
-
      </div>
 
-
            </div>
 
-
            <div class='parameter-control'>
 
-
      <span class="parameter-control-label">Turn-off sensitivity:</span>
 
-
      <div class="input-group">
 
-
<input id="AhlrSensitivityInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
 
-
      </div>
 
-
            </div>
 
-
          </div>
 
         </div>
         </div>
-
      </div>
+
       
-
     
+
       
-
     
+
       
-
     
+
        <!-- ******************* ROW 1 ******************* -->
-
      <!-- ******************* ROW 1 ******************* -->
+
       
-
     
+
       
-
     
+
       
-
     
+
        <div class="parameter-section-row">
-
      <div class="parameter-section-row">
+
         <!-- Algorithmic -->
         <!-- Algorithmic -->
-
        <div class="parameter-section">
+
          <div class="parameter-section">
-
          <p class="section-expand">&#43; Algorithmic Parameters</p>
+
            <p class="section-expand">&#43; Algorithmic Parameters</p>
-
          <div class='parameter-control-container' style='display: none;'>
+
            <div class='parameter-control-container' style='display: none;'>
-
            <div class='parameter-control'>
+
              <div class='parameter-control'>
-
              <span class="parameter-control-label">Delta Time:</span>
+
                <span class="parameter-control-label">Delta Time:</span>
-
              <div class="input-group">
+
                <div class="input-group">
-
                <input id="DeltaTimeInput" type="text" class="form-control" placeholder="0.125"> </input><span class="input-group-addon">min</span>
+
                  <input id="DeltaTimeInput" type="text" class="form-control" placeholder="0.125"> </input><span class="input-group-addon">min</span>
 +
                </div>
               </div>
               </div>
-
            </div>
+
              <div class='parameter-control'>
-
            <div class='parameter-control'>
+
                <span class="parameter-control-label">Data-to-Graph Ratio:</span>
-
              <span class="parameter-control-label">Data-to-Graph Ratio:</span>
+
                <div class="input-group">
-
              <div class="input-group">
+
                 <input id='DataToGraphPointRatioInput' type="text" class="form-control" placeholder="3"> </input><span class="input-group-addon">N/A</span>
                 <input id='DataToGraphPointRatioInput' type="text" class="form-control" placeholder="3"> </input><span class="input-group-addon">N/A</span>
 +
                </div>
               </div>
               </div>
-
            </div>
+
              <div class='parameter-control'>
-
            <div class='parameter-control'>
+
                <span class="parameter-control-label">Data size:</span>
-
              <span class="parameter-control-label">Data size:</span>
+
                <div class="input-group">
-
              <div class="input-group">
+
                 <input id="DataSizeInput" type="text" class="form-control" placeholder="3200"> </input><span class="input-group-addon">N/A</span>
                 <input id="DataSizeInput" type="text" class="form-control" placeholder="3200"> </input><span class="input-group-addon">N/A</span>
 +
                </div>
               </div>
               </div>
             </div>
             </div>
           </div>
           </div>
-
        </div>
+
          <!-- Empty place holders TODO: Move beofre algo -->
-
        <!-- Empty place holders TODO: Move beofre algo -->
+
          <div class="parameter-section">
-
        <div class="parameter-section">
+
            <p class="section-collapse"> - AHL Parameters</p>
-
          <p class="section-collapse"> - AHL Parameters</p>
+
            <div class='parameter-control-container'>
-
          <div class='parameter-control-container'>
+
             <div class='parameter-control'>
             <div class='parameter-control'>
-
      <span class="parameter-control-label">Half-life:</span>
+
              <span class="parameter-control-label">Half-life:</span>
-
      <div class="input-group">
+
              <div class="input-group">
                 <input  id="AhlHalfLifeInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
                 <input  id="AhlHalfLifeInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
-
      </div>
+
              </div>
             </div>
             </div>
             <div class='parameter-control'>
             <div class='parameter-control'>
-
      <span class="parameter-control-label">Promoter Strength:</span>
+
              <span class="parameter-control-label">Promoter Strength:</span>
-
      <div class="input-group">
+
              <div class="input-group">
-
<input  id="AhlStrengthInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
+
              <input  id="AhlStrengthInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
-
      </div>
+
              </div>
             </div>
             </div>
             <div class='parameter-control'>
             <div class='parameter-control'>
-
      <span class="parameter-control-label">Protein Size Factor:</span>
+
              <span class="parameter-control-label">Protein Size Factor:</span>
-
      <div class="input-group">
+
              <div class="input-group">
-
<input id="AhlSizeInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
+
              <input id="AhlSizeInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
-
      </div>
+
              </div>
             </div>
             </div>
             <div class='parameter-control'>
             <div class='parameter-control'>
-
      <span class="parameter-control-label">Turn-off threshold:</span>
+
              <span class="parameter-control-label">Turn-off threshold:</span>
-
      <div class="input-group">
+
              <div class="input-group">
-
<input id="AhlThresholdInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
+
              <input id="AhlThresholdInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
-
      </div>
+
              </div>
             </div>
             </div>
             <div class='parameter-control'>
             <div class='parameter-control'>
-
      <span class="parameter-control-label">Turn-off sensitivity:</span>
+
              <span class="parameter-control-label">Turn-off sensitivity:</span>
-
      <div class="input-group">
+
              <div class="input-group">
-
<input id="AhlSensitivityInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
+
              <input id="AhlSensitivityInput" type="text" class="form-control" placeholder="default"> </input><span class="input-group-addon">units</span>
-
      </div>
+
              </div>
             </div>
             </div>
 +
          </div>
 +
          </div>
 +
          <div class="parameter-section">
 +
            <p class="section-collapse"></p>
           </div>
           </div>
         </div>
         </div>
-
         <div class="parameter-section">
+
       
-
           <p class="section-collapse"></p>
+
       
 +
       
 +
        <!-- ******************* ROW 2 ******************* -->
 +
       
 +
       
 +
       
 +
         <div class="parameter-section-row" >
 +
           <button id="bttnRun" type="button" class="btn btn-primary">Run</button>
         </div>
         </div>
       </div>
       </div>
-
        
+
       <li class='divider'></li>
-
     
+
      <div class="dock">
-
     
+
        <div class="graph-select">
-
      <!-- ******************* ROW 2 ******************* -->
+
        <span class="graph-select-label">Gas Protein </span>
-
     
+
        <div class="graph-group-dropdown-container">
-
     
+
-
     
+
-
      <div class="parameter-section-row" >
+
-
        <button id="bttnRun" type="button" class="btn btn-primary">Run</button>
+
-
      </div>
+
-
    </div>
+
-
    <li class='divider'></li>
+
-
    <div class="dock">
+
-
      <div class="graph-select">
+
-
        <span class="graph-select-label">Gas Protein </span>
+
-
        <div class="graph-group-dropdown-container">
+
           <span class="graph-group-dropdown-label">group:</span>
           <span class="graph-group-dropdown-label">group:</span>
           <select id="gas-protein-group" class="graph-group-dropdown form-control" >
           <select id="gas-protein-group" class="graph-group-dropdown form-control" >
Line 315: Line 318:
             <option>5</option>
             <option>5</option>
           </select>
           </select>
 +
          </div>
         </div>
         </div>
-
      </div>
+
        <div class="graph-select">
-
      <div class="graph-select">
+
          <span class="graph-select-label"> Gas</span>
-
        <span class="graph-select-label"> Gas</span>
+
          <div class="graph-group-dropdown-container">
-
        <div class="graph-group-dropdown-container">
+
           <span class="graph-group-dropdown-label">group:</span>
           <span class="graph-group-dropdown-label">group:</span>
           <select id="gas-group" class="graph-group-dropdown form-control">
           <select id="gas-group" class="graph-group-dropdown form-control">
Line 328: Line 331:
             <option>5</option>
             <option>5</option>
           </select>
           </select>
 +
          </div>
         </div>
         </div>
-
      </div>
+
        <div class="graph-select">
-
      <div class="graph-select">
+
          <span class="graph-select-label"> Gas Protein Repressor</span>
-
        <span class="graph-select-label"> Gas Protein Repressor</span>
+
          <div class="graph-group-dropdown-container">
-
        <div class="graph-group-dropdown-container">
+
           <span class="graph-group-dropdown-label">group:</span>
           <span class="graph-group-dropdown-label">group:</span>
           <select id="repressor-group" class="graph-group-dropdown form-control" >
           <select id="repressor-group" class="graph-group-dropdown form-control" >
Line 341: Line 344:
             <option>5</option>
             <option>5</option>
           </select>
           </select>
 +
          </div>
         </div>
         </div>
-
      </div>
+
        <div class="graph-select">
-
      <div class="graph-select">
+
          <span class="graph-select-label">AHLR</span>
-
        <span class="graph-select-label">AHLR</span>
+
          <div class="graph-group-dropdown-container">
-
        <div class="graph-group-dropdown-container">
+
           <span class="graph-group-dropdown-label">group:</span>
           <span class="graph-group-dropdown-label">group:</span>
           <select id="ahlr-group" class="graph-group-dropdown form-control" >
           <select id="ahlr-group" class="graph-group-dropdown form-control" >
Line 354: Line 357:
             <option>5</option>
             <option>5</option>
           </select>
           </select>
 +
          </div>
         </div>
         </div>
-
      </div>
+
        <div class="graph-select">
-
      <div class="graph-select">
+
          <span class="graph-select-label"> AHL Synthesis</span>
-
        <span class="graph-select-label"> AHL Synthesis</span>
+
          <div class="graph-group-dropdown-container">
-
        <div class="graph-group-dropdown-container">
+
           <span class="graph-group-dropdown-label">group:</span>
           <span class="graph-group-dropdown-label">group:</span>
           <select id="ahl-group" class="form-control graph-group-dropdown" >
           <select id="ahl-group" class="form-control graph-group-dropdown" >
Line 367: Line 370:
             <option selected="selected">5</option>
             <option selected="selected">5</option>
           </select>
           </select>
 +
          </div>
         </div>
         </div>
       </div>
       </div>
 +
      <div class="graph-display">
 +
        <div class="graph-label section-collapse"> - Graph group 1</div>
 +
        <div id="graph-group1" class="graph"></div>
 +
        <div class="graph-label section-collapse"> - Graph group 2</div>
 +
        <div id="graph-group2" class="graph"></div>
 +
        <div class="graph-label section-collapse"> - Graph group 3</div>
 +
        <div id="graph-group3" class="graph"></div>
 +
        <div class="graph-label section-collapse"> - Graph group 4</div>
 +
        <div id="graph-group4" class="graph"></div>
 +
        <div class="graph-label section-collapse"> - Graph group 5</div>
 +
        <div id="graph-group5" class="graph"></div>
 +
       
 +
      </div>
 +
      <li class='divider'></li>
     </div>
     </div>
-
    <div class="graph-display">
+
-
      <div class="graph-label section-collapse"> - Graph group 1</div>
+
-
      <div id="graph-group1" class="graph"></div>
+
<div class="description">
-
       <div class="graph-label section-collapse"> - Graph group 2</div>
+
       <h2>Governing equations</h2>
-
      <div id="graph-group2" class="graph"></div>
+
      <h3>Gas production/dissipation</h3>
-
      <div class="graph-label section-collapse"> - Graph group 3</div>
+
      <p>
-
      <div id="graph-group3" class="graph"></div>
+
The rate of production of gas is proportional to the amount of gas protein in the system, and some gas  
-
      <div class="graph-label section-collapse"> - Graph group 4</div>
+
        dissipates at a constant rate. Thus,         
-
      <div id="graph-group4" class="graph"></div>
+
        $$ {dQ_{gas} \over dt}  = P_{gas} \cdot Q_{gp} - D_{gas}  $$
-
      <div class="graph-label section-collapse"> - Graph group 5</div>
+
</p><br>
-
      <div id="graph-group5" class="graph"></div>
+
      <h3>Gas Protein Production/Decay</h3>
-
     
+
<p>
-
    </div>
+
        The production of the gas protein is affected negatively by its size,  
-
    <li class='divider'></li>
+
        and positively by the promoter strength. <br><br>
-
  </div>
+
        Given enough repressor, the production of the protein drops exponentially to zero.<br>
-
 
+
        Furthermore, it degrades with a given half-life. <br>
-
 
+
        Thus,
-
  <div class="description">
+
        $$
-
    <h2>Governing equations</h2>
+
        {dQ_{gp}\over dt} = \left\{  
-
    <h3>Gas production/dissipation</h3>
+
        \begin{array}{l l}
-
    <p>
+
          -{Q_{gp} \cdot ln(1/2) \over \tau_{\text{gp-halflife}} } + P_{prom\_str} \cdot P_{size\_fact} \cdot e ^ { {- ( Q_{rep} - P_{thresh} ) / P_{thresh\_sensitivity} }} & \quad \text{if $Q_{rep} >= P_{thresh}$ }\\
-
      The rate of production of gas is proportional to the amount of gas protein in the system, and some gas  
+
          -{Q_{gp} \cdot ln(1/2) \over \tau_{\text{gp-halflife}} } + P_{prom\_str} \cdot P_{size\_fact}  & \quad \text{o.w. }
-
      dissipates at a constant rate. Thus,         
+
        \end{array} \right.
-
      $$ {dQ_{gas} \over dt}  = P_{gas} \cdot Q_{gp} - D_{gas}  $$
+
        $$
-
    </p><br>
+
        Alright. The first half of this stuff is the half-life. Tau itself is the half-life.<br>
-
    <h3>Gas Protein Production/Decay</h3>
+
        For this reason, the half-life is present regardless of the amount of repressor.<br>
-
    <p>
+
        The second part is the production. <br><br>
-
      The production of the gas protein is affected negatively by its size,  
+
        On the second equation, if the repressor is at small quantities, then the production is uninhibited. <br>
-
      and positively by the promoter strength. <br><br>
+
        On the first equation, if there is enough repressor, the production quickly drops to zero, at an exponential rate.
-
      Given enough repressor, the production of the protein drops exponentially to zero.<br>
+
        How sensitive, or quick this "switch-off" occurs is controlled by the threshold sensitivity.<br>
-
      Furthermore, it degrades with a given half-life. <br>
+
        The larger this factor, the slower the switch-off/switch-on.
-
      Thus,
+
</p><br>
-
      $$
+
      <h3>Repressor Production/Decay</h3>
-
      {dQ_{gp}\over dt} = \left\{  
+
<p>
-
      \begin{array}{l l}
+
The repressor is promoted by the presence of gas. It will not be produced, if there is no gas.<br>
-
      -{Q_{gp} \cdot ln(1/2) \over \tau_{\text{gp-halflife}} } + P_{prom\_str} \cdot P_{size\_fact} \cdot e ^ { {- ( Q_{rep} - P_{thresh} ) / P_{thresh\_sensitivity} }} & \quad \text{if $Q_{rep} >= P_{thresh}$ }\\
+
        There has to be enough gas for the repressor to be generated. This is the repressor's threshold.<br>
-
      -{Q_{gp} \cdot ln(1/2) \over \tau_{\text{gp-halflife}} } + P_{prom\_str} \cdot P_{size\_fact}  & \quad \text{o.w. }
+
        The repressor itself has a half-life.<br>
-
      \end{array} \right.
+
        Thus,
-
      $$
+
        $$
-
      Alright. The first half of this stuff is the half-life. Tau itself is the half-life.<br>
+
        {dQ_{rep}\over dt} = \left\{  
-
      For this reason, the half-life is present regardless of the amount of repressor.<br>
+
        \begin{array}{l l}
-
      The second part is the production. <br><br>
+
          -{Q_{rep} \cdot ln(1/2) \over \tau_{\text{rep-halflife}} } + R_{prom\_str} \cdot R_{size\_fact} - R_{prom\_str} \cdot R_{size\_fact} \cdot e ^ { {- ( Q_{gas} - R_{thresh} ) / R_{thresh\_sensitivity} }} & \quad \text{if $Q_{gas} >= R_{thresh}$ }\\
-
      On the second equation, if the repressor is at small quantities, then the production is uninhibited. <br>
+
          -{Q_{rep} \cdot ln(1/2) \over \tau_{\text{rep-halflife}} }  & \quad \text{o.w. }
-
      On the first equation, if there is enough repressor, the production quickly drops to zero, at an exponential rate.
+
        \end{array} \right.
-
      How sensitive, or quick this "switch-off" occurs is controlled by the threshold sensitivity.<br>
+
        $$
-
      The larger this factor, the slower the switch-off/switch-on.
+
</p>
-
    </p><br>
+
      <br><br>
-
    <h3>Repressor Production/Decay</h3>
+
      <p>
-
    <p>
+
        &copy; COMPUT-E.COLI, Gabriel Belmonte<br/>
-
      The repressor is promoted by the presence of gas. It will not be produced, if there is no gas.<br>
+
        Powered by:<br/>
-
      There has to be enough gas for the repressor to be generated. This is the repressor's threshold.<br>
+
        &nbsp;&nbsp;<a href="https://developers.google.com/chart/">Google Visualization</a> for graphing<br/>
-
      The repressor itself has a half-life.<br>
+
        &nbsp;&nbsp;<a href="http://www.mathjax.org/">MathJax</a> for LaTeX math equation rendering.<br/>
-
      Thus,
+
      </p>
-
      $$
+
</div>
-
      {dQ_{rep}\over dt} = \left\{  
+
-
      \begin{array}{l l}
+
-
      -{Q_{rep} \cdot ln(1/2) \over \tau_{\text{rep-halflife}} } + R_{prom\_str} \cdot R_{size\_fact} - R_{prom\_str} \cdot R_{size\_fact} \cdot e ^ { {- ( Q_{gas} - R_{thresh} ) / R_{thresh\_sensitivity} }} & \quad \text{if $Q_{gas} >= R_{thresh}$ }\\
+
-
      -{Q_{rep} \cdot ln(1/2) \over \tau_{\text{rep-halflife}} }  & \quad \text{o.w. }
+
-
      \end{array} \right.
+
-
      $$
+
-
    </p>
+
-
    <br><br>
+
-
    <p>
+
-
      &copy; COMPUT-E.COLI Simulation, Gabriel Belmonte<br/>
+
-
      Powered by:<br/>
+
-
      &nbsp;&nbsp;<a href="https://developers.google.com/chart/">Google Visualization</a> for graphing<br/>
+
-
      &nbsp;&nbsp;<a href="http://www.mathjax.org/">MathJax</a> for LaTeX math equation rendering.<br/>
+
-
    </p>
+
-
  </div>
+
</div>
</div>

Revision as of 06:32, 27 September 2013

logo

Numerical Analysis of Gene Regulatory Network Protein Synthesis and Decay

+ Parameters

  • Gas Protein
    group:
    Gas
    group:
    Gas Protein Repressor
    group:
    AHLR
    group:
    AHL Synthesis
    group:
    - Graph group 1
    - Graph group 2
    - Graph group 3
    - Graph group 4
    - Graph group 5
  • Governing equations

    Gas production/dissipation

    The rate of production of gas is proportional to the amount of gas protein in the system, and some gas dissipates at a constant rate. Thus, $$ {dQ_{gas} \over dt} = P_{gas} \cdot Q_{gp} - D_{gas} $$


    Gas Protein Production/Decay

    The production of the gas protein is affected negatively by its size, and positively by the promoter strength.

    Given enough repressor, the production of the protein drops exponentially to zero.
    Furthermore, it degrades with a given half-life.
    Thus, $$ {dQ_{gp}\over dt} = \left\{ \begin{array}{l l} -{Q_{gp} \cdot ln(1/2) \over \tau_{\text{gp-halflife}} } + P_{prom\_str} \cdot P_{size\_fact} \cdot e ^ { {- ( Q_{rep} - P_{thresh} ) / P_{thresh\_sensitivity} }} & \quad \text{if $Q_{rep} >= P_{thresh}$ }\\ -{Q_{gp} \cdot ln(1/2) \over \tau_{\text{gp-halflife}} } + P_{prom\_str} \cdot P_{size\_fact} & \quad \text{o.w. } \end{array} \right. $$ Alright. The first half of this stuff is the half-life. Tau itself is the half-life.
    For this reason, the half-life is present regardless of the amount of repressor.
    The second part is the production.

    On the second equation, if the repressor is at small quantities, then the production is uninhibited.
    On the first equation, if there is enough repressor, the production quickly drops to zero, at an exponential rate. How sensitive, or quick this "switch-off" occurs is controlled by the threshold sensitivity.
    The larger this factor, the slower the switch-off/switch-on.


    Repressor Production/Decay

    The repressor is promoted by the presence of gas. It will not be produced, if there is no gas.
    There has to be enough gas for the repressor to be generated. This is the repressor's threshold.
    The repressor itself has a half-life.
    Thus, $$ {dQ_{rep}\over dt} = \left\{ \begin{array}{l l} -{Q_{rep} \cdot ln(1/2) \over \tau_{\text{rep-halflife}} } + R_{prom\_str} \cdot R_{size\_fact} - R_{prom\_str} \cdot R_{size\_fact} \cdot e ^ { {- ( Q_{gas} - R_{thresh} ) / R_{thresh\_sensitivity} }} & \quad \text{if $Q_{gas} >= R_{thresh}$ }\\ -{Q_{rep} \cdot ln(1/2) \over \tau_{\text{rep-halflife}} } & \quad \text{o.w. } \end{array} \right. $$



    © COMPUT-E.COLI, Gabriel Belmonte
    Powered by:
      Google Visualization for graphing
      MathJax for LaTeX math equation rendering.