Team:Dundee

From 2013.igem.org

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<div id="template" style="text-align: center; font-weight: bold; font-size: large; color: #f6f6f6; padding: 5px;">
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This is a template page. READ THESE INSTRUCTIONS.
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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
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You <strong>MUST</strong> have all of the pages listed in the menu below with the names specified. PLEASE keep all of your pages within your teams namespace. 
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{|align="justify"
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                <div class="item"><!-- add the active class to any slider you want shown first -->
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|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
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                  <img src="https://static.igem.org/mediawiki/2013/thumb/a/a4/Algal_Bloom3.jpg/800px-Algal_Bloom3.jpg" style="width:100%;height:100%">
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|[[Image:Dundee_logo.png|200px|right|frame]]
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''Tell us more about your project. Give us background.  Use this as the abstract of your project. Be descriptive but concise (1-2 paragraphs)''
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|[[Image:Dundee_team.png|right|frame|Your team picture]]
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|align="center"|[[Team:Dundee | Team Dundee]]
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!align="center"|[[Team:Dundee|Home]]
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!align="center"|[[Team:Dundee/Team|Team]]
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                </div>
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!align="center"|[https://igem.org/Team.cgi?year=2013&team_name=Dundee Official Team Profile]
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!align="center"|[[Team:Dundee/Project|Project]]
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!align="center"|[[Team:Dundee/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:Dundee/Modeling|Modeling]]
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!align="center"|[[Team:Dundee/Notebook|Notebook]]
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!align="center"|[[Team:Dundee/Safety|Safety]]
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!align="center"|[[Team:Dundee/Attributions|Attributions]]
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        <h2 style="margin-top:-10px;"> Targeting a Deadly Toxin</h2>
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        Explosions in the population of cyanobacteria can produce toxic algal blooms. Microcystin-LR the most potent and common algal bloom toxin, binds Protein Phosphatase 1. The average cyanobacteria infested lake in America contains over 1000 times the Microcystin safe drinking water limit set by the World Health Organisation. <br><br>
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        Concerned by a harmful algal bloom in the local community, we used synthetic biology to target the toxin. We exploited the mechanism of Microcystin's toxicity to develop our Mop; by expressing Protein Phosphatase 1 we can mop up Microcystin. The interaction was also the basis for developing a biological Detector. To deploy our Detector and to consider the root causes of algal blooms we created the electronic Moptopus. It sits on a lake and monitors conditions relevant to cyanobacterial growth to help predict future blooms.
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        <a href="https://2013.igem.org/Team:Dundee/Project">
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                          <p><b style="font-size:16px">Mop</b><br><br> Mopping up a toxin (microcystin) by engineering a bacterium to produce the human PP1 protein, the protein to which microcystin binds.</p>
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        <a href="https://2013.igem.org/Team:Dundee/Project/Detector">
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                          <p><b style="font-size:16px;">Detector</b><br><br> Detecting microcystin by manipulation of the <i>E. coli</i> osmoregulator EnvZ.</p>
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        <a href="https://2013.igem.org/Team:Dundee/Project/SoftwareTheory">
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                          <p><b style="font-size:16px;">Moptopus</b><br><br>  An electronic sensing device that provides a platform for toxin detection. It relates a range of environmental conditions to algal bloom formation and toxicity.</p>
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        <a href="https://2013.igem.org/Team:Dundee/HumanPractice">
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                          <p><b style="font-size:16px;">Human Practices</b><br><br>This project has been carried out in collaboration with the community. By informing, listening and responding to their input, our project is based around community defined need, and is not merely a technical exercise. </p>
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        <p class="muted credit"> Created for <a href="https://igem.org/Main_Page">iGEM 2013</a> Dundee. Based upon <a href ="http://twitter.github.io/bootstrap/">Bootstrap</a> and <a href="http://jquery.com/">JQuery</a>. Design by <a href="http://www.kyleharrison.co.uk">Kyle Harrison </a>. </p>
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Latest revision as of 23:35, 28 October 2013

iGEM Dundee 2013 · ToxiMop

Dundee 2013

Targeting a Deadly Toxin

Explosions in the population of cyanobacteria can produce toxic algal blooms. Microcystin-LR the most potent and common algal bloom toxin, binds Protein Phosphatase 1. The average cyanobacteria infested lake in America contains over 1000 times the Microcystin safe drinking water limit set by the World Health Organisation.

Concerned by a harmful algal bloom in the local community, we used synthetic biology to target the toxin. We exploited the mechanism of Microcystin's toxicity to develop our Mop; by expressing Protein Phosphatase 1 we can mop up Microcystin. The interaction was also the basis for developing a biological Detector. To deploy our Detector and to consider the root causes of algal blooms we created the electronic Moptopus. It sits on a lake and monitors conditions relevant to cyanobacterial growth to help predict future blooms.



Retrieved from "http://2013.igem.org/Team:Dundee"