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Team:Evry/Modeling
From 2013.igem.org
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| - | <center><h1>Modeling:</h1></center> | + | <center><h1 style="text-align:center">Modeling:</h1></center> |
| - | The modeling part is planned around 4 main targets: | + | <p>The modeling part is planned around 4 main targets: |
<ul> | <ul> | ||
<li>Growth of an iron-chelating bacterial population | <li>Growth of an iron-chelating bacterial population | ||
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<li>Bacterial activity : iron-chelation rate, avidity (cellular scale) | <li>Bacterial activity : iron-chelation rate, avidity (cellular scale) | ||
<li>Intestine mapping and interactions | <li>Intestine mapping and interactions | ||
| - | </ul> | + | </ul></p> |
| - | <center | + | <h2 style="text-align:center">First approach: </h2> |
| - | For a better understanding of the bacteria our team is going to produce, we chose to first focus on the growth of an iron-chelating bacterial population. | + | <p>For a better understanding of the bacteria our team is going to produce, we chose to first focus on the growth of an iron-chelating bacterial population.</p> |
| - | < | + | <p>Let us suppose we have <math>N_0</math> initial siderophore-producing bacterias in a closed system with dissolved iron. Monitoring the evolution of those bacterias, the dissolved iron, the siderophores and the chelated iron through a simple model will help our biologists tune their constructions.</p> |
| - | <img:systeme differentiel/><br/><br/> | + | <!--<img:systeme differentiel/><br/><br/> |
where α is the Mc Kellar adaptation factor:<br/><br/> | where α is the Mc Kellar adaptation factor:<br/><br/> | ||
| - | <img:McKellar><br/><br/> | + | <img:McKellar><br/><br/>--> |
<script type="text/javascript">writeFooter()</script> | <script type="text/javascript">writeFooter()</script> | ||
</html> | </html> | ||
Revision as of 09:03, 25 July 2013
Modeling:
The modeling part is planned around 4 main targets:
- Growth of an iron-chelating bacterial population
- Risk assessment : forecast, control, auto-regulation, ...
- Bacterial activity : iron-chelation rate, avidity (cellular scale)
- Intestine mapping and interactions
First approach:
For a better understanding of the bacteria our team is going to produce, we chose to first focus on the growth of an iron-chelating bacterial population.
Let us suppose we have initial siderophore-producing bacterias in a closed system with dissolved iron. Monitoring the evolution of those bacterias, the dissolved iron, the siderophores and the chelated iron through a simple model will help our biologists tune their constructions.
