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Team:Evry/Protein Chelator
From 2013.igem.org
An alternative iron chelator
At the Regional Jamboree, we discussed with Edinburgh team which also work on iron chelation but with another chelator: the ferric ion-binding protein A (FbpA).
This protein from Neisseria gonorrhoeae is able to chelate various ion in solution as Fe3+
, Ti4+,Cu2+, Zr4+(Zirconium ion)
or Hf4+ (Hafnium ion).
Its affinity for ferrous iron is 1018, less than our enterobactins system, but it remains a good alternative for our treatment.
References:
- Alexeev, D., Zhu, H., Guo, M., Zhong, W., Hunter, D., Yang, W., Campopiano, D. and Sadler, P. (2003) A novel protein-mineral interface. Nature Structural Biology. 10. 297-302.
- Ferreiros, C., Criado, M. and Gomez, J. (1999) The Neisserial 37kDa ferric binding protein (FbpA). Comparative Biochemistry and Physiology Part B. 123. 1-7.
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