Team:Fudan/test-content

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<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en"> <head> <meta http-equiv="Content-Type" content="text/html;charset=UTF-8" /> <title>ALeader</title> <link rel="stylesheet" type="text/css" href="http://new87.guangstreet.com/css/reset.css" media="all" /> <link rel="stylesheet" type="text/css" href="http://new87.guangstreet.com/css/style.css" media="all" /> <script type="text/javascript" src="http://new87.guangstreet.com/js/jquery-1.9.min.js"></script> <script type="text/javascript" src="http://new87.guangstreet.com/js/main.js"></script> </head> <body> <div id="total-wrap"> <div id="header"> <div id="emp"> <a href="https://igem.org"><div id="logo"> </div></a> </div> <div id="top-menu"> <div class="top-menu-each"> <p>Home</p> </div> <div class="top-menu-each"> <div class="arrow"></div> <p>Team</p> <div class="top-menu-sub"> <ul> <a href="/members.html"><li>Members</li></a> <a href="/attribution.html"><li>Attribution</li></a> <a href="/team_profile.html"><li>Team Profile</li></a> <a href="/notebook.html"><li>Notebook</li></a> </ul> </div> </div> <div class="top-menu-each"> <div class="arrow"></div> <p>Project</p> <div class="top-menu-sub"> <ul> <a href="/overview.html"><li>Overview</li></a> <a href="/input.html"><li>Input</li></a> <a href="/defination.html"><li>Defination</li></a> <a href="/estimation.html"><li>Estimation</li></a> <a href="/optimization.html"><li>Optimization</li></a> <a href="/application.html"><li>Application</li></a> </ul> </div> </div> <div class="top-menu-each"> <div class="arrow"></div> <p>Modeling</p> <div class="top-menu-sub"> <ul> <a href="/triphase_riboswitch.html"><li>Triphase Riboswitch</li></a> <a href="/bistable_system.html"><li>Bistable System</li></a> </ul> </div> </div> <div class="top-menu-each"> <div class="arrow"></div> <p>Supplementary</p> <div class="top-menu-sub"> <ul> <a href="/meterial.html"><li>Meterial</li></a> <a href="/protocol.html"><li>Protocol</li></a> </ul> </div> </div> <div class="top-menu-each"> <div class="arrow"></div> <p>Human Practice</p> <div class="top-menu-sub"> <ul> <a href="/pedia.html"><li>Pedia</li></a> <a href="/outreach.html"><li>Outreach</li></a> </ul> </div> </div> <div class="top-menu-each"> <p>Safety</p> </div> <div class="top-menu-each"> <a href="/gallery.html"><p>Gallery</p></a> </div> </div> </div> <div id="big-photo"> <div id="big-photo-wrap"> <img src="http://new87.guangstreet.com/img/DSQ.png" alt="pic"> <div id="big-photo-hover"> <p class="header">Background of Leader RNA</p> <p class="content">Riboswitches are regulatory RNAs that regulate gene expression by binding small molecule metabolites. Our Aleader riboswitch is such kind of regulatory parts that is induced by aminoglycoside drug.</p> </div> </div> </div> <div id="small-photo"> <div class="small-photo-each"> <img src="" alt="" /> </div> <div class="small-photo-each"> <img src="" alt="" /> </div> <div class="small-photo-each last"> <img src="" alt="" /> </div> </div> <div id="footer"> </div> </div> </body> </html>
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<p>Home</p>
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<ul><li>ALeader</li><li>Swing Spinach</li><li>Milk</li></ul>
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<div class="top-menu-each"><p>Supplementary</p></div>
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<div class="left-bar-each top">ALEADER</div>
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<div class="left-bar-each">Overview</div>
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<div class="left-bar-each">Design</div>
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<div class="left-bar-each">Terminator</div>
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<p>What is the disadvantage of a common biphase riboswitch? And why we want to purpose a novel design principle based on the idea of a triphase riboswitch?
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Here we compared the general model of the biphase and triphase riboswitch, to demonstrate the differences.
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We started with a coursedcoarse-grained description of the riboswitch function, in order to construct a model to yield a detailed relationship between the ligand concentration (L) and protein levels (P). In this diagram, only the dominant conformations calculated, and the noise is neglected. In the general model, the three major mechanisms were considered: translational repression, transcriptional termination and the mRNA degradation. And to simplifyied the model, firstly at first we only considered the thermodynamically driven regime[] of the model, in which all the conformational changeings are reversible. </p>
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<p>What is the disadvantage of a common biphase riboswitch? And why we want to purpose a novel design principle based on the idea of a triphase riboswitch?
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Here we compared the general model of the biphase and triphase riboswitch, to demonstrate the differences.
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We started with a coursedcoarse-grained description of the riboswitch function, in order to construct a model to yield a detailed relationship between the ligand concentration (L) and protein levels (P). In this diagram, only the dominant conformations calculated, and the noise is neglected. In the general model, the three major mechanisms were considered: translational repression, transcriptional termination and the mRNA degradation. And to simplifyied the model, firstly at first we only considered the thermodynamically driven regime[] of the model, in which all the conformational changeings are reversible. </p>
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Revision as of 15:41, 27 September 2013

ALeader

pic

Background of Leader RNA

Riboswitches are regulatory RNAs that regulate gene expression by binding small molecule metabolites. Our Aleader riboswitch is such kind of regulatory parts that is induced by aminoglycoside drug.

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