Team:Fudan/test-content

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<a href="https://igem.org"><div id='logo'> </div></a>
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<p>Home</p>
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<a href="https://2013.igem.org/team:fudan"><p>Home</p></a>
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<a href="/members.html"><li>Members</li></a>
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<a href="/team:fudan/members.html"><li>Members</li></a>
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<a href="/attribution.html"><li>Attribution</li></a>
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<a href="/team:fudan/attribution.html"><li>Attribution</li></a>
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<a href="/team_profile.html"><li>Team Profile</li></a>
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<a href="/notebook.html"><li>Notebook</li></a>
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<a href="/team:fudan/overview.html"><li>Overview</li></a>
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<a href="/input.html"><li>Input</li></a>
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<a href="/team:fudan/input.html"><li>Input</li></a>
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<a href="/defination.html"><li>Defination</li></a>
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<a href="/team:fudan/defination.html"><li>Defination</li></a>
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<a href="/estimation.html"><li>Estimation</li></a>
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<a href="/team:fudan/estimation.html"><li>Estimation</li></a>
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<a href="/optimization.html"><li>Optimization</li></a>
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<a href="/team:fudan/optimization.html"><li>Optimization</li></a>
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<a href="/application.html"><li>Application</li></a>
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<a href="/Team:fudan/triphase_riboswitch.html"><li>Triphase Riboswitch</li></a>
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<a href="/bistable_system.html"><li>Bistable System</li></a>
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<a href="/protocol.html"><li>Protocol</li></a>
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<a href="/team:fudan/pedia.html"><li>Pedia</li></a>
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<a href="/outreach.html"><li>Outreach</li></a>
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<a href="/team:fudan/outreach.html"><li>Outreach</li></a>
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<div class="left-bar-each top">ALEADER</div>
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<p class="header">Background of Leader RNA</p>
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<div class="left-bar-each">Overview</div>
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<p class="content">Riboswitches are regulatory RNAs that regulate gene expression by binding small molecule metabolites. Our Aleader riboswitch is such kind of regulatory parts that is induced by aminoglycoside drug.</p>
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<div class="left-bar-each">Design</div>
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<div class="left-bar-each">Terminator</div>
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<div class="left-bar-each">Three State</div>
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<div class="left-bar-each">TCD</div>
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<div class="left-bar-each">Modelling</div>
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<p>What is the disadvantage of a common biphase riboswitch? And why we want to purpose a novel design principle based on the idea of a triphase riboswitch?
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Here we compared the general model of the biphase and triphase riboswitch, to demonstrate the differences.
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We started with a coursedcoarse-grained description of the riboswitch function, in order to construct a model to yield a detailed relationship between the ligand concentration (L) and protein levels (P). In this diagram, only the dominant conformations calculated, and the noise is neglected. In the general model, the three major mechanisms were considered: translational repression, transcriptional termination and the mRNA degradation. And to simplifyied the model, firstly at first we only considered the thermodynamically driven regime[] of the model, in which all the conformational changeings are reversible. </p>
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<p>What is the disadvantage of a common biphase riboswitch? And why we want to purpose a novel design principle based on the idea of a triphase riboswitch?
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<div class="small-photo-each last">
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Here we compared the general model of the biphase and triphase riboswitch, to demonstrate the differences.
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<img src="" alt="" />
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We started with a coursedcoarse-grained description of the riboswitch function, in order to construct a model to yield a detailed relationship between the ligand concentration (L) and protein levels (P). In this diagram, only the dominant conformations calculated, and the noise is neglected. In the general model, the three major mechanisms were considered: translational repression, transcriptional termination and the mRNA degradation. And to simplifyied the model, firstly at first we only considered the thermodynamically driven regime[] of the model, in which all the conformational changeings are reversible. </p>
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Latest revision as of 20:22, 27 September 2013

ALeader

ALEADER
Overview
Design
Terminator
Three State
TCD
Modelling
Data

What is the disadvantage of a common biphase riboswitch? And why we want to purpose a novel design principle based on the idea of a triphase riboswitch? Here we compared the general model of the biphase and triphase riboswitch, to demonstrate the differences. We started with a coursedcoarse-grained description of the riboswitch function, in order to construct a model to yield a detailed relationship between the ligand concentration (L) and protein levels (P). In this diagram, only the dominant conformations calculated, and the noise is neglected. In the general model, the three major mechanisms were considered: translational repression, transcriptional termination and the mRNA degradation. And to simplifyied the model, firstly at first we only considered the thermodynamically driven regime[] of the model, in which all the conformational changeings are reversible.

What is the disadvantage of a common biphase riboswitch? And why we want to purpose a novel design principle based on the idea of a triphase riboswitch? Here we compared the general model of the biphase and triphase riboswitch, to demonstrate the differences. We started with a coursedcoarse-grained description of the riboswitch function, in order to construct a model to yield a detailed relationship between the ligand concentration (L) and protein levels (P). In this diagram, only the dominant conformations calculated, and the noise is neglected. In the general model, the three major mechanisms were considered: translational repression, transcriptional termination and the mRNA degradation. And to simplifyied the model, firstly at first we only considered the thermodynamically driven regime[] of the model, in which all the conformational changeings are reversible.