Revision as of 11:18, 29 September 2013

Heat Motility

The goal for our heat motility system is to obtain a higher concentration of silk in close proximity to the implant, which is achieved by immobilizing the silk producing bacteria once they are within some distance to the impant. The biological systems enabling this are the standard chemotaxis system and the DesK membrane fluidity sensor system (Link!). These systems have been modified and coupled to oneanother in order to stop B. Subtilis from moving when it is 37°C, and to make it swim when it is 25°C. In our model we simulate the behaviour of these systems and, if necessary, implement biologically plausible modifications to make it feasible.

The chemotaxis system of B. subtilis

The CheV subsystem

The methylation subsystem

The CheC CheD subsystem

Exact adaption

Motility model

Homogenous and non-homogenous environments

CheC knockout

The effects of temperature

The DesK system

Demonstration

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	<h1>Heat Motility</h1>		<h1>Heat Motility</h1>
-	The goal for our heat motility system~~(link!)~~ is to obtain a higher concentration of silk in close proximity to the implant, which is achieved by immobilizing the silk producing bacteria once they are within some distance to the impant. The biological systems enabling this are the standard chemotaxis system and the DesK membrane fluidity sensor system. These systems have been modified and coupled to oneanother in order to stop ''B. Subtilis'' from moving when it is 37°C, and to make it swim when it is 25°C. In our model we simulate the behaviour of these systems and, if necessary, implement biologically plausible modifications to make it feasible.	+	The goal for our heat motility system is to obtain a higher concentration of silk in close proximity to the implant, which is achieved by immobilizing the silk producing bacteria once they are within some distance to the impant. The biological systems enabling this are the standard chemotaxis system and the DesK membrane fluidity sensor system (Link!). These systems have been modified and coupled to oneanother in order to stop ''B. Subtilis'' from moving when it is 37°C, and to make it swim when it is 25°C. In our model we simulate the behaviour of these systems and, if necessary, implement biologically plausible modifications to make it feasible.

Team:Groningen/Modeling/Heatmotility

From 2013.igem.org