Team:Michigan/Modeling

From 2013.igem.org

(Difference between revisions)
(Inducible Hbif Model)
(Expression Model)
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[[File:Expression.jpg|center]]
[[File:Expression.jpg|center]]
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[https://docs.google.com/document/d/18ur0oiT7_mHhmd7Nk9vDJtsAGuFecNA1CtgTz9HAjsA/edit?usp=sharing Expression Model (Link)]
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[https://docs.google.com/document/d/18ur0oiT7_mHhmd7Nk9vDJtsAGuFecNA1CtgTz9HAjsA/edit?usp=sharing Expression Model Derivation]
=Switch Model=
=Switch Model=

Revision as of 23:25, 27 September 2013

Xayona Website Template

Contents

Overview

Best model.jpg

Model of Recombinase Expression

Model of the Switch

Model of Inducible Hbif

Introduction

switch modeling

• goals: produce both states of switch, use model to optimize switch

mass action modeling

• what is mass action

• pros of mass action modeling, i.e. why we used it

• form of mass action models/solvability doc

analytical modeling:

• benefits

   • naturally standardized
   
   • given parameters, it precisely predicts behavior
   • accurately predicts the data needed to determine parameters
   • allows avoidance of numerical errors like rounding

• ERSESCO

   • equation
   • reduction
   • solution
   • equilibration
   • stabilization
   • calibration
   • optimization

File:Solvability.pdf

Expression Model

ExpressionModelFigure.png

Equation:

ExpressionModel1.png

Reduction: None

Solution:

ExpressionModel2.png

Equilibration:

ExpressionModel3.png

Stabilization:

ExpressionModel3-1.png

Calibration:

ExpressionModel4.png
ExpressionModel5.png

Optimization:

ExpressionModel6.png
Expression.jpg

Expression Model Derivation

Switch Model

SwitchModelFigure.png

Equation:

SwitchModel1.png
SwitchModel2.png

Reduction:

SwitchModel3.png

Solution:

SwitchModel3-1.png

Equilibration:

SwitchModel4-1.png

Stabilization:

SwitchModel4-2.png

Calibration:

SwitchModel5-1.png
SwitchModel5-2.png

Optimization:

SwitchModel6.png
Switch.jpg

Switch Model (Link)

Inducible Hbif Model

InducibleHbifModelFigure.png

Equation:

InducibleHbifModel1.png
InducibleHbifModel2.png

Reduction:

InducibleHbifModel3.png

Solution:

InducibleHbifModel4.png

Equilibration:

InducibleHbifModel5.png

Stabilization:

InducibleHbifModel5-2.png

Calibration:

InducibleHbifModel6-1.png
InducibleHbifModel6-2.png
InducibleHbifModel6-3.png

Optimization of Hbif:

InducibleHbifModel7-1.png

Optimization of ON:

InducibleHbifModel7-2.png

SimBiology:

InducedHbif.jpg

Inducible Hbif Model (Link)

Future Directions

Data!

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