Team:Penn/Project2
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<p>The code of life is much more than a sequence of A's, G's, C's and T's; | <p>The code of life is much more than a sequence of A's, G's, C's and T's; | ||
a suite of epigenetic mechanisms, ranging from chromatin remodeling to non-coding RNAs, | a suite of epigenetic mechanisms, ranging from chromatin remodeling to non-coding RNAs, | ||
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Revision as of 00:27, 11 August 2013
Abstract
The code of life is much more than a sequence of A's, G's, C's and T's; a suite of epigenetic mechanisms, ranging from chromatin remodeling to non-coding RNAs, affect gene expression and cellular function.
Synthetic biologists and geneticists are accustomed to turning genes on and off at will, but the tools don’t exist to easily manipulate epigenetic patterns. We are developing a novel fusion protein that enables site-specific methylation, which can repress promoter activity with high precision.