|
|
| Line 25: |
Line 25: |
| | <img src="http://upload.wikimedia.org/wikipedia/en/d/d6/IGEM_official_logo.png" id="igem"/><!--igem logo--> | | <img src="http://upload.wikimedia.org/wikipedia/en/d/d6/IGEM_official_logo.png" id="igem"/><!--igem logo--> |
| | <img src="http://collegediabetesnetwork.org/wp-content/uploads/2012/07/UPenn_logo1.png" id="penn"/> <!--penn logo--> | | <img src="http://collegediabetesnetwork.org/wp-content/uploads/2012/07/UPenn_logo1.png" id="penn"/> <!--penn logo--> |
| - | <div class="left_wrap"> | + | |
| - | <div class="section1"><!--page wrapper-->
| + | |
| - | <div class="text"><!--white text box-->
| + | |
| - | <h2>ABSTRACT</h2> <!--title-->
| + | |
| - | <p>The code of life is much more than a sequence of A's, G's, C's and T's;
| + | |
| - | a suite of epigenetic mechanisms, ranging from chromatin remodeling to non-coding RNAs,
| + | |
| - | affect gene expression and cellular function. <div class="figure-wrap" style="margin-left: 200px;"><img class="figure" src="https://googledrive.com/host/0B4ZBZOYYKBzEeG5XLTdURjc0aTA" "/>
| + | |
| - | <img class="figure" src="https://googledrive.com/host/0B4ZBZOYYKBzEeG05enR0ZFFXeEE" />
| + | |
| - | <img class="figure" src="https://googledrive.com/host/0B4ZBZOYYKBzEXzVMY3EtX284cTA" /></div>
| + | |
| - | <p> In particular, DNA methylation has been
| + | |
| - | shown to alter transcriptional activity in a powerful, heritable manner. Abnormal methylation
| + | |
| - | patterns are associated with diseases including immunodeficiency syndromes, neurodevelopmental
| + | |
| - | disorders, and many types of cancer. Comprehensive understanding and control of DNA methylation
| + | |
| - | could be invaluable to researchers studying these diseases.</p>
| + | |
| - |
| + | |
| - |
| + | |
| - | <p>Synthetic biologists and geneticists are accustomed to turning genes on and off at will,
| + | |
| - | but the tools don’t exist to easily manipulate epigenetic patterns. We are developing a novel
| + | |
| - | fusion protein that enables site-specific methylation, which can repress promoter activity with
| + | |
| - | high precision. <div class="figure-wrap" style="float: center;"><img src="https://googledrive.com/host/0B4ZBZOYYKBzEdmZMalozd0pkSjg" style="height: 75px; margin: 5px; float: left;"/>
| + | |
| - | <img src="https://googledrive.com/host/0B4ZBZOYYKBzEdlExOEgtVlZYYUU" style="height: 75px; float: left; margin: 5px;"/></div><p>In coming years, this fusion protein could become a powerful tool for epigenetics
| + | |
| - | researchers looking to perform on/off studies in the vein of classical genetics, as well as an
| + | |
| - | orthogonal mode of repressing constitutive promoters for bacterial synthetic biologists.
| + | |
| - | Eventually, it could even give clinical researchers the means to restore healthy methylation
| + | |
| - | levels in many insofar-untreatable epigenetic diseases.</p>
| + | |
| - | <img src="https://googledrive.com/host/0B4ZBZOYYKBzEMzM5dWpRQWNvb1k" style="height: 75px; display: inline; float: right; margin: 5px;"/>
| + | |
| - | <img src="https://googledrive.com/host/0B4ZBZOYYKBzEek95VVUyMkltSHc" style="height: 75px; float: right; margin: 5px; "/>
| + | |
| - | </div>
| + | |
| | | | |
| | | | |
"
