Team:SYSU-Software

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<span>Computer Aided Synbio Tool-<br/>An Integrated Tool for Synthetic Biology</span>
<span>Computer Aided Synbio Tool-<br/>An Integrated Tool for Synthetic Biology</span>
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<div id="banner-middle" class="banner-tips"><img src="https://static.igem.org/mediawiki/2013/a/a1/Cast_logo_robot_head.png"><b>Welcome</b></div>
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<!-- <p>Synthetic Biology, depending on interdisciplinary knowledge and experience, cooperates wet and dry experiments to engineer the artificial biological systems. Here, our team has developed an integrated tool, <b>CAST (Computer Aided Synbio Tool)</b>, to address specific technical challenges in synthetic biology. Our software can automatically perform the regulatory networks and gene circuits designing with Biobricks and other regulatory elements, modeling, vector designing and proposal build. User can also optimize or alter the default methods to fulfill some further demands. All of the designed elements, networks and vectors can be stored in database to be shared through CAST. In addition, we incorporated <a href="https://2013.igem.org/Team:SYSU-Software/wetlab"><b>wetlab experimentation</b></a> into our project to validate our <a href="https://2013.igem.org/Team:SYSU-Software/model"><b>new simulation model</b></a> that work with standard dynamic characteristic. Altogether, <b>the combination of the <font color="#ff0000">design automation</font>, <font color="#ff0000">innovative models and algorithms</font>, and <font color="#ff0000">wetlab validation</font> makes complex biological systems accessible to researchers who want rapid, intuitive, and high-quality accomplish their designs</b>. -->
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<p>Synthetic Biology, depending on interdisciplinary knowledge and experience, cooperates wet and dry experiments to engineer the artificial biological systems. Our team has developed an integrated tool, <b>CAST (Computer Aided Synbio Tool)</b>, to address specific technical challenges in synthetic biology. Our software can automatically perform the regulatory networks and gene circuits designing, modeling, vector designing and proposal build.All of the design can be stored in database to be shared through CAST. In addition, we incorporated <a href="https://2013.igem.org/Team:SYSU-Software/wetlab"><b>wetlab experimentation</b></a> into our project to validate our <a href="https://2013.igem.org/Team:SYSU-Software/model"><b>new simulation model</b></a> that work with standard dynamic characteristic. Altogether, <b>the combination of the <font>design automation</font>, <font>innovative models and algorithms</font>, and <font>wetlab validation</font> makes complex biological systems accessible to researchers who want rapid, intuitive, and high-quality accomplish their designs.</b>
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<a href="https://2013.igem.org/Team:SYSU-Software/designer#part2" class="component-tooltip"  data-placement="top" title data-original-title="Is that possible that a software is able to generate gene circuits automatically? We are proud to announce that CAST can. According to users’ network constructed, our software will find all appropriate components to fabricate demanded gene circuits. Adjusting the parameters of these components, CAST will modify the gene circuits to fulfill your wish.
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<a href="https://2013.igem.org/Team:SYSU-Software/designer#part3" class="component-tooltip"  data-placement="top" title data-original-title="Real-time reaction is a important feature for excellent software. While you are adjusting the parameters, the change on the model will reflect simultaneously and present the expression curve. To gain a more practical result, CAST can perform a stochastic or time-delay model.
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<a href="https://2013.igem.org/Team:SYSU-Software/designer#part2" class="component-tooltip"  data-placement="top" title data-original-title="Is that possible that a software is able to generate gene circuits automatically? We are proud to announce that CAST can. According to users’ network constructed, our software will find all appropriate components to fabricate demanded gene circuits. Adjusting the parameters of these components, CAST will modify the gene circuits to fulfill your wish.
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<a href="https://2013.igem.org/Team:SYSU-Software/designer#part1" class="component-tooltip"  data-placement="top" title data-original-title="Is that possible that a software is able to generate gene circuits automatically? We are proud to announce that CAST can. According to users’ network constructed, our software will find all appropriate components to fabricate demanded gene circuits. Adjusting the parameters of these components, CAST will modify the gene circuits to fulfill your wish.
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<a href="https://2013.igem.org/Team:SYSU-Software/designer#part2" class="component-tooltip"  data-placement="top" title data-original-title="Is that possible that a software is able to generate gene circuits automatically? We are proud to announce that CAST can. According to users’ network constructed, our software will find all appropriate components to fabricate demanded gene circuits. Adjusting the parameters of these components, CAST will modify the gene circuits to fulfill your wish.
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<a href="https://2013.igem.org/Team:SYSU-Software/designer#part4" class="component-tooltip"  data-placement="top" title data-original-title="As automation is our soul, the plasmid is constructed without your worrying. The plasmid will be presented intuitively and detailedly. Even better, you can select different assembly standard as you wish.
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<a href="https://2013.igem.org/Team:SYSU-Software/designer#part5" class="component-tooltip"  data-placement="top" title data-original-title="Being a amateur and find it hard to begin? Do not worry! CAST is a considerable assistant. Your can accomplish your synthetic biology design under our detailed direction."><img src="https://static.igem.org/mediawiki/2013/c/cc/Component6.png"></a>
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<a href="https://2013.igem.org/Team:SYSU-Software/designer#part5" class="component-tooltip"  data-placement="top" title data-original-title="Being a amateur and find it hard to begin? Do not worry! CAST is a considerable assistant. Your can accomplish your synthetic biology design under our detailed direction."><img src="https://static.igem.org/mediawiki/2013/b/b9/Component7.png"></a>
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<a href="https://2013.igem.org/Team:SYSU-Software/designer#part1" class="component-tooltip"  data-placement="top" title data-original-title="People want function proteins instead of complicated regulatory elements accompanied. We offer a simple network designer to programme the basic regulatory relations among interested proteins-----all regulatory elements are concealed, just to emphasize the protein collaboration."><img src="https://static.igem.org/mediawiki/2013/d/d0/Component_coli.png"></a>
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<a href="https://2013.igem.org/Team:SYSU-Software/designer#part1" class="component-tooltip"  data-placement="top" title data-original-title="People want function proteins instead of complicated regulatory elements accompanied. We offer a simple network designer to programme the basic regulatory relations among interested proteins-----all regulatory elements are concealed, just to emphasize the protein collaboration."><img src="https://static.igem.org/mediawiki/2013/d/d0/Component_regulation_network.png"></a>
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<h2>Introduction</h2>
 
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<p>Accurate simulation and gene circuit design are essential but difficult parts in synthetic biology.Here, we designed CAST to cover the workflow from beginning to end, users can focus on function design and the gene circuit would be automatically designed. Furthermore, we developed a new simulation model that work with standard dynamic characteristic and verified by wetlab experiments. Moreover, we build an expandable database that users can contribute their own dynamic information which would lead to more accurate and sufficient dynamic information of all the Biobricks. Finally, our software is designed as an easy deployed server so that it can be used on personal purpose or shared by a whole lab or institution.
 
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Sun Yat-Sen University, Guangzhou, China<br/>
Sun Yat-Sen University, Guangzhou, China<br/>
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Latest revision as of 08:35, 3 June 2014

Team:SYSU-Software