Team:Tufts/Team

From 2013.igem.org

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<div id="template" style="text-align: center; font-weight: bold; font-size: large; color: #f6f6f6; padding: 5px;">
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This is a template page. READ THESE INSTRUCTIONS.
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You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2008.igem.org/Help:Template/Examples">HERE</a>.
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<div id="warning" style="text-align: center; font-weight: bold; font-size: small; color: #f6f6f6; padding: 5px;">
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You <strong>MUST</strong> have all of the pages listed in the menu below with the names specified.  PLEASE keep all of your pages within your teams namespace. 
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<!-- *** End of the alert box *** -->
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<div style="line-height: 220px">
 
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<a href="https://2012.igem.org/Team:MIT/Motivation#s2">
 
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  <img src="https://static.igem.org/mediawiki/2012/4/44/Mithomepage1.png" alt="Why make logic circuits with strand displacement?" style="border:1px solid black" width="250"/>
 
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</a>
 
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<a href="https://2012.igem.org/Team:MIT/Motivation">
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  <img src="https://static.igem.org/mediawiki/2012/5/52/Mithomepage3.png" alt="How does strand displacement work?" style="border:1px solid black" width="250"/>
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|You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing.
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</a>
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|[[Image:Tufts_logo.png|200px|right|frame]]
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|[[Image:Tufts_team.png|right|frame|Your team picture]]
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|align="center"|[[Team:Tufts | Team Tufts]]
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<a href="https://2012.igem.org/Team:MIT/TheKeyReaction#SDbio">
 
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  <img src="https://static.igem.org/mediawiki/2012/d/dd/Mithomepage5.png" alt="Strand displacement reactions work in vivo!" style="border:1px solid black" width="250"/>
 
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</a>
 
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<br />
 
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<a href="https://2012.igem.org/Team:MIT/Sensing#sensing1bio">
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<!--- The Mission, Experiments --->
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  <img src="https://static.igem.org/mediawiki/2012/8/81/Mithomepage4.png" alt="Sensing mRNA Levels using Strand Displacement" style="border:1px solid black" width="250"/>
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</a>
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<a href="https://2012.igem.org/Team:MIT/NOTGate#NOTgate_designbio">
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{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
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  <img src="https://static.igem.org/mediawiki/2012/b/b7/Mithomepage6.png" alt="Strand Displacement NOT Gate Design" style="border:1px solid black" width="250"/>
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!align="center"|[[Team:Tufts|Home]]
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</a>
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!align="center"|[[Team:Tufts/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2013&team_name=Tufts Official Team Profile]
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!align="center"|[[Team:Tufts/Project|Project]]
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!align="center"|[[Team:Tufts/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:Tufts/Modeling|Modeling]]
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!align="center"|[[Team:Tufts/Notebook|Notebook]]
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!align="center"|[[Team:Tufts/Safety|Safety]]
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!align="center"|[[Team:Tufts/Attributions|Attributions]]
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|}
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<a href="https://2012.igem.org/Team:MIT/CircuitProduction#shortRNAbio">
 
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  <img src="https://static.igem.org/mediawiki/2012/b/b0/Mithomepage2.png" alt="Making short RNAs in vivo to use in circuits" style="border:1px solid black" width="250"/><br/>
 
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<h3>Project Description</h3>
 
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<p>
 
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<p>The limited availability of promoters, genes, and repressors, along with the difficulty in assembling and delivering large DNA plasmids bottleneck advances in sophistication of genetic circuits in mammalian systems. In contrast, sophistication of <i>in vitro</i> synthetic DNA circuits has grown exponentially through the mechanism of <a href="https://2012.igem.org/Team:MIT/Motivation">toehold-mediated strand displacement</a>. These circuits demonstrate digital logic with reliable, modular, and scalable behaviors and maintain a small base-pair footprint. </p> <p>
 
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The raw processing power of these strand displacement circuits has been trapped in the test tube, sequestered from the traditional protein-based sensing, processing, and actuation method of synthetic biology. With the adaptation of strand displacement-based information processing, the application space of synthetic biology circuits will become larger and more accessible. </p>
 
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<p>
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== '''Who we are''' ==
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Our project leverages strand displacement to create a processing technology that supports multi-input <b>sensing</b>, sophisticated <b>information processing</b>, and precisely-regulated <b>actuation</b> in mammalian cells. We designed and tested a novel <a href="https://2012.igem.org/Team:MIT/NOTGate">fully-functioning DNA NOT gate</a>, which enables complete logic operation. In addition, we used RNA strand displacement to <a href="https://2012.igem.org/Team:MIT/Sensing">sense cellular mRNA</a>. We also demonstrated our ability to <a href="https://2012.igem.org/Team:MIT/CircuitProduction#shortRNAbio">produce short RNAs</a> <i>in vivo</i>.
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<p>
 
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Most importantly, we demonstrated that toehold-mediated strand displacement in RNA can occur in mammalian cells. This, combined with our feasibility studies outlined in the above paragraph, shows that <a href="https://2012.igem.org/Team:MIT/TheKeyReaction#iteration_2_invivo"><b>strand displacement is a viable information-processing technology</b></a>. We envision <i>in vivo</i> RNA strand displacement as a new foundation for scaling up complexity in engineered biological systems, with applications in biosynthesis, biomedical diagnostics and therapeutics.
 
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</p>
 
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</div>
 
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'''Advisors:'''
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<br /><br />
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*''' Advisor 1''':    Mentor for all
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*'''Advisor 2''':      Our favorite
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*'''Grad Student 1''':    Our leader 
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<h3>Sponsors</h3>
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'''Undergrads:'''
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<ul id="leftsponsors">
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  <li><a href="http://www.eecs.mit.edu/"><img src='https://static.igem.org/mediawiki/2011/2/22/Mit-eecs.jpg' /></a></li>
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  <li><a href="http://web.mit.edu/be/"><img src='https://static.igem.org/mediawiki/2011/a/a7/Mit-be.jpg' /></a></li>
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  <li><a href="http://web.mit.edu/cheme/"><img src='https://static.igem.org/mediawiki/2012/0/01/Cheme.png' style="width:175px"></a></li>
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  <li><a href="https://2012.igem.org/Main_Page"><img src='https://static.igem.org/mediawiki/igem.org/d/de/IGEM_basic_Logo_stylized.png' style="width:175px;"></a></li>
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  <li><a href="http://www.alnylam.com"><img src='https://static.igem.org/mediawiki/2012/1/16/ALYNYAM.jpg' style = "width:175px;"'></a></li>
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</ul>
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<ul id="centersponsors">
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*'''Student 1''':   Sleepyhead
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  <li><a href="http://www.geneious.com"><img src='https://static.igem.org/mediawiki/2011/6/65/Mit-geneious.jpg' /></a></li>
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*'''Student 2''':   Math nerd
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  <li><a href="http://www.genewiz.com"><img src='https://static.igem.org/mediawiki/2011/3/33/Mit-genewiz.jpg' /></a></li>
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*'''Student 3''':    Is going to save the world
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  <li><a href="http://www.neb.com"><img src='https://static.igem.org/mediawiki/2011/4/4d/Mit-neb.jpg' /></a></li>
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*'''Student 4''':    Loves iGEM
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  <li><a href="http://www.addgene.org/"><img src='https://static.igem.org/mediawiki/2012/5/58/Addgene.png' /></a></li>
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*'''Student 5''': A normal student... or(r) am I?
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  <li><a href="http://www.genscript.com/"><img src='https://static.igem.org/mediawiki/2012/8/80/Genscript_logo2.jpg' /></a>
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*'''Student 6''':  Table football fan
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</li>
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*'''Student 7''':
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  <li><a href="http://www.pfizer.com"><img src='http://upload.wikimedia.org/wikipedia/en/7/77/Pfizerlogo.gif' width=175></a></li>
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</ul>
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<ul id="rightsponsors">
 
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  <li><a href="http://ebics.net"><img src='https://static.igem.org/mediawiki/igem.org/0/0d/EBICS_logo.JPG' style="width:175px"></a></li>
 
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  <li><a href="http://ehs.mit.edu/site/"><img src='https://static.igem.org/mediawiki/2012/5/52/Ehs_logo.jpg'></a></li>
 
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  <li><a href="http://www.monsanto.com/Pages/default.aspx"><img src='https://static.igem.org/mediawiki/2012/1/18/Monsanto.png'></a></li>
 
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  <li><a href="http://www.flagshipventures.com/"><img src='https://static.igem.org/mediawiki/2012/3/3c/VentureLabsLogo.jpeg' style="width:175px"></a></li>
 
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  <li><a href="http://www.thirdrockventures.com"><img src='https://static.igem.org/mediawiki/2012/c/ca/TRV.jpg' style="width:175px"></a></li>
 
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  <li><a href="http://www.idtdna.com/site"><img src='https://static.igem.org/mediawiki/2012/4/41/Idt2.png'></a></li>
 
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  <li><a href="http://www.cmea.com/team/team-karl-handelsman.php"><img src='https://static.igem.org/mediawiki/2012/f/f0/Karl_Handelsman_logo.png' width=175> </a></li>
 
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<gallery>
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Image:Example2_Team_member_1.png|Team member 1
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Image:Example2_Team_member_2.png|Team member 2
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Image:Example2_Team_member_3.png|Team member 3
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Image:Example2_Team_member_4.png|Team member 4
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Image:Example2_Team_member_5.png|Team member 5
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Image:Example2_Team_member_6.png|Team member 6
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Image:Example2_Team_member_7.png|Team member 7
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</gallery>
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|}
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</ul>
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== '''What we did''' ==
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<br />
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(Provide proper attribution for all work)
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</div> <!--End of col_center-->
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== '''Where we're from''' ==
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</body>
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</html>
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Revision as of 00:54, 26 June 2013


This is a template page. READ THESE INSTRUCTIONS.
You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples HERE.
You MUST have all of the pages listed in the menu below with the names specified. PLEASE keep all of your pages within your teams namespace.


You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing.
File:Tufts logo.png
200px
File:Tufts team.png
Your team picture
Team Tufts


Home Team Official Team Profile Project Parts Submitted to the Registry Modeling Notebook Safety Attributions


Who we are



Advisors:

  • Advisor 1: Mentor for all
  • Advisor 2: Our favorite
  • Grad Student 1: Our leader


Undergrads:

  • Student 1: Sleepyhead
  • Student 2: Math nerd
  • Student 3: Is going to save the world
  • Student 4: Loves iGEM
  • Student 5: A normal student... or(r) am I?
  • Student 6: Table football fan
  • Student 7:


Team member 1

Team member 2

Team member 3

Team member 4

Example2 Team member 5.png

Team member 5

Example2 Team member 6.png

Team member 6

Example2 Team member 7.png

Team member 7

What we did

(Provide proper attribution for all work)


Where we're from

Retrieved from "http://2013.igem.org/Team:Tufts/Team"