Team:UCL/Background

From 2013.igem.org

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                <p class="major_title">BACKGROUND INFO</p>
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<p class="major_title">WHAT IS ALZHEIMER'S?</p>
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<p class="minor_title">Alzheimer's Disease</p>
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<p class="minor_title">Dementia</p>
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Our project this year blends the fields of synthetic biology and neuroscience. We aim to demonstrate that genetic engineering techniques can be applied to the brain, creating synthetic biological systems capable of rectifying abnormalities in the brain on a cellular and macromolecular level<br><br></p>
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Dementia is an age related neurodegenerative condition, characterised by failure of recent memory and intellectual functions (attention, language, visual-spatial orientation, abstract thinking, judgement), and tends to progress steadily. These changes are due to the mounting dysfunction and death of brain cells, called neurons, that are responsible for the storage and computation of information. Late stages of the disease often see patients bedridden, mute and incontinent. Although some drugs can temporarily improve memory, pharmaceutical research, through enlightening, has been clinically unsuccessfulAt present there are no treatments that can halt, let alone revert, the inexorable progression of dementia. The treatments that do exist are purely symptomatic (Citron 2010).  
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Such novel application of synthetic biology could offer new ways to treat brain diseases, such as our target, Alzheimer’s disease, for which most modern pharmaceutical treatment is purely symptomatic. </p>
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Revision as of 17:43, 14 August 2013

WHAT IS ALZHEIMER'S?

Dementia

Dementia is an age related neurodegenerative condition, characterised by failure of recent memory and intellectual functions (attention, language, visual-spatial orientation, abstract thinking, judgement), and tends to progress steadily. These changes are due to the mounting dysfunction and death of brain cells, called neurons, that are responsible for the storage and computation of information. Late stages of the disease often see patients bedridden, mute and incontinent. Although some drugs can temporarily improve memory, pharmaceutical research, through enlightening, has been clinically unsuccessful. At present there are no treatments that can halt, let alone revert, the inexorable progression of dementia. The treatments that do exist are purely symptomatic (Citron 2010).