Team:Heidelberg

From 2013.igem.org

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<a href="https://2013.igem.org"><object data="https://static.igem.org/mediawiki/2013/b/b3/Heidelberg_igem_logo2.png" height="70" style="left:0.5%; margin-top:-2%"></object></a>
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'''Welcome on Heidelberg 2013's wiki!'''  <br/> <br/>
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We are a highly motivated team of 13 undergraduate students from the University of Heidelberg, all with different scientific backgrounds including Molecular Biotechnology, Biology and Systems Biology. Our team is supervised by Prof. Dr. Roland Eils and Dr. Barbara DiVentura from the University of Heidelberg and the German Cancer Research Center (DKFZ) and supported by eight advisors.
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'''What we are working on:''' <br/><br/>
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Numerous non-ribosomal peptides such as antibiotics, chelators of metals, dyes and detoxificating enzymes are produced in an alternative ribosome-independent pathway as secondary metabolites, found in fungi and various bacteria. The chain of modules the enzyme - called non-ribosomal peptide synthetase (NRPS) - consists of, subsequently adds a defined amino acid to build a template-independent peptide chain. Every module’s sequence of subdomains furthermore encodes for possible chemical modifications of the amino acid.  
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We will investigate modularity of the NRPS systems giving rise to the assembly of novel, engineered synthetases and subsequent synthesis of artificial non-ribosomal peptides. Currently, we are establishing the introduction of different NRPS pathways into ''E. coli''. Our aim is to prove interchangeability of NRPS modules and domains from different host organisms. Smaller peptide synthetases, e.g. producing dyes, are used for the exchange of domains, whereas more complex synthetases, e.g. producing antibiotics, were chosen to investigate module exchangeability.  
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                <h2 class="">Team</h2>
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We wish to share the enormous potential of non-ribosomal peptide synthetases with the iGEM community by establishing a standard system for these synthetases, supported by an implemented software framework. Thereby, we are going to simplify manufacturing and applicability of non-ribosomal peptides in order to offer a cost- and energy-efficient alternative for the synthesis of biomolecules. As secondary metabolites, these peptides play important roles in basic research (such as dyes), pharmaceutical development (such as antibiotics) and recycling (such as chelators).
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                    <li><a href="#">Student Members</a></li>
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                    <li><a href="#">Attributions</a></li>
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                    <li><a href="#">Instructors</a></li>
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                <h2 class="">Project</h2>
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    <li><a href="#">Overview</a></li>
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                    <li><a href="#">Indigoidine</a></li>
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                    <li><a href="#">Tyrocidine</a></li>
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                    <li><a href="#">Delftibactin</a></li>
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            <div class="item notebook">
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                <h2>Notebook</h2>
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                    <li><a href="#">Indigoidine</a></li>
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                    <li><a href="#">Tyrocidine</a></li>
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                    <li><a href="#">Delftibactin</a></li>
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                </ul>
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            <div class="item parts">
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                <h2>Parts</h2>
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                    <li><a href="#">Favorite parts</a></li>
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            <div class="item software">
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                <h2 class="">Software</h2>
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                    <li><a href="#">NRPS designer</a></li>
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                    <li><a href="#">iGEM42</a></li>
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                <h2>Outreach</h2>
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                    <li><a href="#">Outreach</a></li>
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                    <li><a href="#">Ethical consideration</a></li>
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            <div class="item safety">
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                <h2>Safety</h2>
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                    <li><a href="#">Biosafety sheet</a></li>
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                    <li><a href="#">Be save in the lab</a></li>
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            <a href="https://www.facebook.com/pages/IGEM-Team-Heidelberg-2013/265102553624765"><img src="https://static.igem.org/mediawiki/2013/5/55/Heidelberg_Fb.png" height="50" style="float:right; margin-right:10%"/></a>
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            <a href="https://twitter.com/igem_heidelberg"><img src="https://static.igem.org/mediawiki/2013/1/1c/Heidelberg_Tw.png" height="50" style="float:right; margin-right:2% "/></a>
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            <span style="float:right; margin-top:10%; margin-right:5%;; font-family:Arial, sans-serif" class="btn btn-default btn-lg btn-popover" data-content="For centuries, alchemists believed in the existence of the Philosopher’s Stone, a mysterious substance not only able to turn common metals into precious ones, such as silver and gold, but even capable of fulfilling mankind’s ultimate desires: rejuvenation and immortality.
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            Although the Philosopher’s Stone has never been found, the quest for it has pushed alchemists to test in their laboratories numerous substances and their interactions, building up a solid knowledge that can be found nowadays in the sciences of chemistry, metallurgy and pharmacology. </br>
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            Living in the 21st century research-driven world, our belief in the Philosopher’s Stone has faded. Yet we are, now as ever, still on a quest, looking for solutions not only to help individuals live long and healthy, but also to solve the ecological problems we ourselves have created in the course of modernization. Contrary to the past, we now believe that we should not simply look for magical substances hidden somewhere in nature, rather we shall be inspired by it and create new tools for actively addressing the challenges of our society.</br>
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            Let us take you on a journey where you will meet a new class of molecules that holds the potential to revolutionize synthetic biology: the non-ribosomal peptide synthetases. We will teach you how to unlock their enormous potential for generating entirely synthetic peptides with various, customized functions, such as recycling gold from electronic waste.
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            Take your chance!</br>
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            Join our quest!" title="" data-tigger="click" data-title="Welcome!">Welcome! Click here!</span>
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            <h3 style="font-size:21px; float:right; margin-right:5%">Check out our Highlights:</h3>
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Revision as of 21:01, 3 October 2013