Team:Tufts/Team

From 2013.igem.org

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{| style="color:#1b2c8a;background-color:#FFFFFF;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="99%" align="center"
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<a href="https://2012.igem.org/Team:MIT/Motivation#s2">
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!align="center"|[[Team:Tufts|Home]]
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  <img src="https://static.igem.org/mediawiki/2012/4/44/Mithomepage1.png" alt="Why make logic circuits with strand displacement?" style="border:1px solid black" width="250"/>
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!align="center"|[[Team:Tufts/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2013&team_name=Tufts Official Team Profile]
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!align="center"|[[Team:Tufts/Project|Project]]
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!align="center"|[[Team:Tufts/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:Tufts/Modeling|Modeling]]
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!align="center"|[[Team:Tufts/Notebook|Notebook]]
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!align="center"|[[Team:Tufts/Safety|Safety]]
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!align="center"|[[Team:Tufts/Attributions|Attributions]]
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<a href="https://2012.igem.org/Team:MIT/Motivation">
 
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  <img src="https://static.igem.org/mediawiki/2012/5/52/Mithomepage3.png" alt="How does strand displacement work?" style="border:1px solid black" width="250"/>
 
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<a href="https://2012.igem.org/Team:MIT/TheKeyReaction#SDbio">
 
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  <img src="https://static.igem.org/mediawiki/2012/d/dd/Mithomepage5.png" alt="Strand displacement reactions work in vivo!" style="border:1px solid black" width="250"/>
 
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<br />
 
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<a href="https://2012.igem.org/Team:MIT/Sensing#sensing1bio">
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== '''Who we are''' ==
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  <img src="https://static.igem.org/mediawiki/2012/8/81/Mithomepage4.png" alt="Sensing mRNA Levels using Strand Displacement" style="border:1px solid black" width="250"/>
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<a href="https://2012.igem.org/Team:MIT/NOTGate#NOTgate_designbio">
 
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  <img src="https://static.igem.org/mediawiki/2012/b/b7/Mithomepage6.png" alt="Strand Displacement NOT Gate Design" style="border:1px solid black" width="250"/>
 
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<a href="https://2012.igem.org/Team:MIT/CircuitProduction#shortRNAbio">
 
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  <img src="https://static.igem.org/mediawiki/2012/b/b0/Mithomepage2.png" alt="Making short RNAs in vivo to use in circuits" style="border:1px solid black" width="250"/><br/>
 
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<h3>Project Description</h3>
 
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<p>The limited availability of promoters, genes, and repressors, along with the difficulty in assembling and delivering large DNA plasmids bottleneck advances in sophistication of genetic circuits in mammalian systems. In contrast, sophistication of <i>in vitro</i> synthetic DNA circuits has grown exponentially through the mechanism of <a href="https://2012.igem.org/Team:MIT/Motivation">toehold-mediated strand displacement</a>. These circuits demonstrate digital logic with reliable, modular, and scalable behaviors and maintain a small base-pair footprint. </p> <p>
 
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The raw processing power of these strand displacement circuits has been trapped in the test tube, sequestered from the traditional protein-based sensing, processing, and actuation method of synthetic biology. With the adaptation of strand displacement-based information processing, the application space of synthetic biology circuits will become larger and more accessible. </p>
 
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Our project leverages strand displacement to create a processing technology that supports multi-input <b>sensing</b>, sophisticated <b>information processing</b>, and precisely-regulated <b>actuation</b> in mammalian cells. We designed and tested a novel <a href="https://2012.igem.org/Team:MIT/NOTGate">fully-functioning DNA NOT gate</a>, which enables complete logic operation. In addition, we used RNA strand displacement to <a href="https://2012.igem.org/Team:MIT/Sensing">sense cellular mRNA</a>. We also demonstrated our ability to <a href="https://2012.igem.org/Team:MIT/CircuitProduction#shortRNAbio">produce short RNAs</a> <i>in vivo</i>.
 
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'''Advisors:'''
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<p>
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*''' Advisor 1''':    Mentor for all
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Most importantly, we demonstrated that toehold-mediated strand displacement in RNA can occur in mammalian cells. This, combined with our feasibility studies outlined in the above paragraph, shows that <a href="https://2012.igem.org/Team:MIT/TheKeyReaction#iteration_2_invivo"><b>strand displacement is a viable information-processing technology</b></a>. We envision <i>in vivo</i> RNA strand displacement as a new foundation for scaling up complexity in engineered biological systems, with applications in biosynthesis, biomedical diagnostics and therapeutics.
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*'''Advisor 2''':     Our favorite
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*'''Grad Student 1''':     Our leader 
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</p>
 
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'''Undergrads:'''
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*'''Student 1''':    Sleepyhead
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*'''Student 2''':    Math nerd
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*'''Student 3''':    Is going to save the world
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*'''Student 4''':    Loves iGEM
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*'''Student 5''':  A normal student... or(r) am I?
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*'''Student 6''':  Table football fan
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*'''Student 7''':
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<br /><br />
 
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Image:Example2_Team_member_01.png|Team member 1
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Image:Example2_Team_member_02.png|Team member 2
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Image:Example2_Team_member_03.png|Team member 3
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Image:Example2_Team_member_04.png|Team member 4
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Image:Example2_Team_member_05.png|Team member 5
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Image:Example2_Team_member_06.png|Team member 6
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Image:Example2_Team_member_07.png|Team member 7
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<h3>Sponsors</h3>
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== '''What we did''' ==
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<ul id="leftsponsors">
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  <li><a href="http://www.eecs.mit.edu/"><img src='https://static.igem.org/mediawiki/2011/2/22/Mit-eecs.jpg' /></a></li>
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  <li><a href="http://web.mit.edu/be/"><img src='https://static.igem.org/mediawiki/2011/a/a7/Mit-be.jpg' /></a></li>
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  <li><a href="http://web.mit.edu/cheme/"><img src='https://static.igem.org/mediawiki/2012/0/01/Cheme.png' style="width:175px"></a></li>
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  <li><a href="https://2012.igem.org/Main_Page"><img src='https://static.igem.org/mediawiki/igem.org/d/de/IGEM_basic_Logo_stylized.png' style="width:175px;"></a></li>
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  <li><a href="http://www.alnylam.com"><img src='https://static.igem.org/mediawiki/2012/1/16/ALYNYAM.jpg' style = "width:175px;"'></a></li>
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<ul id="centersponsors">
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(Provide proper attribution for all work)
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  <li><a href="http://www.geneious.com"><img src='https://static.igem.org/mediawiki/2011/6/65/Mit-geneious.jpg' /></a></li>
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  <li><a href="http://www.genewiz.com"><img src='https://static.igem.org/mediawiki/2011/3/33/Mit-genewiz.jpg' /></a></li>
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  <li><a href="http://www.neb.com"><img src='https://static.igem.org/mediawiki/2011/4/4d/Mit-neb.jpg' /></a></li>
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  <li><a href="http://www.addgene.org/"><img src='https://static.igem.org/mediawiki/2012/5/58/Addgene.png' /></a></li>
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  <li><a href="http://www.genscript.com/"><img src='https://static.igem.org/mediawiki/2012/8/80/Genscript_logo2.jpg' /></a>
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  <li><a href="http://www.pfizer.com"><img src='http://upload.wikimedia.org/wikipedia/en/7/77/Pfizerlogo.gif' width=175></a></li>
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== '''Where we're from''' ==
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  <li><a href="http://ebics.net"><img src='https://static.igem.org/mediawiki/igem.org/0/0d/EBICS_logo.JPG' style="width:175px"></a></li>
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  <li><a href="http://ehs.mit.edu/site/"><img src='https://static.igem.org/mediawiki/2012/5/52/Ehs_logo.jpg'></a></li>
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  <li><a href="http://www.monsanto.com/Pages/default.aspx"><img src='https://static.igem.org/mediawiki/2012/1/18/Monsanto.png'></a></li>
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  <li><a href="http://www.flagshipventures.com/"><img src='https://static.igem.org/mediawiki/2012/3/3c/VentureLabsLogo.jpeg' style="width:175px"></a></li>
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  <li><a href="http://www.thirdrockventures.com"><img src='https://static.igem.org/mediawiki/2012/c/ca/TRV.jpg' style="width:175px"></a></li>
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  <li><a href="http://www.idtdna.com/site"><img src='https://static.igem.org/mediawiki/2012/4/41/Idt2.png'></a></li>
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  <li><a href="http://www.cmea.com/team/team-karl-handelsman.php"><img src='https://static.igem.org/mediawiki/2012/f/f0/Karl_Handelsman_logo.png' width=175> </a></li>
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Latest revision as of 01:50, 13 August 2013


same goes. This sections is the html and the bottom section is only temporary.


Home Team Official Team Profile Project Parts Submitted to the Registry Modeling Notebook Safety Attributions


Who we are



Advisors:

  • Advisor 1: Mentor for all
  • Advisor 2: Our favorite
  • Grad Student 1: Our leader


Undergrads:

  • Student 1: Sleepyhead
  • Student 2: Math nerd
  • Student 3: Is going to save the world
  • Student 4: Loves iGEM
  • Student 5: A normal student... or(r) am I?
  • Student 6: Table football fan
  • Student 7:


Example2 Team member 01.png

Team member 1

Example2 Team member 02.png

Team member 2

Example2 Team member 03.png

Team member 3

Example2 Team member 04.png

Team member 4

Example2 Team member 05.png

Team member 5

Example2 Team member 06.png

Team member 6

Example2 Team member 07.png

Team member 7

What we did

(Provide proper attribution for all work)

Where we're from

Retrieved from "http://2013.igem.org/Team:Tufts/Team"