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| - | <p><i>Escherichia coli</i> is an Enterobacteria described by <a href="http://archive.org/stream/bergeysmanualofd1957amer/bergeysmanualofd1957amer_djvu.txt"> | + | <p><i>Escherichia coli</i> is an Enterobacteria described by <a href="http://archive.org/stream/bergeysmanualofd1957amer/bergeysmanualofd1957amer_djvu.txt">Bergey's Manual (1957)</a>. <i>Escherichia</i> is a Gram-negative rod which can be motile by peritrichous flagella or nonmotile. <i>Escherichia</i> is also a facultative anaerobe which has both a respiratory and a fermentative type of metabolism, and commonly occurs in the intestinal tract of humans and other animals. The strain <i>E. coli</i> K-12 is a debilitated strain which does not normally colonize the human intestine. It has also been shown to survive poorly in the environment, has a history of safe commercial use, and is not known to have adverse effects on microorganisms or plants. </p> |
<p>Because of its wide use as a model organism in research in microbial genetics and physiology, and its use in industrial applications, E. coli K-12 is one of the most extensively studied microorganisms. As a result, these K-12 strains are well-characterized and should be expected to remain as pure cultures under standard microbiological practices. K-12 strains are distinguishable from other Escherichia.</p> | <p>Because of its wide use as a model organism in research in microbial genetics and physiology, and its use in industrial applications, E. coli K-12 is one of the most extensively studied microorganisms. As a result, these K-12 strains are well-characterized and should be expected to remain as pure cultures under standard microbiological practices. K-12 strains are distinguishable from other Escherichia.</p> | ||
<p>According to the <a | <p>According to the <a | ||
| - | href="http://epa.gov/oppt/biotech/pubs/fra/fra004.htm"> | + | href="http://epa.gov/oppt/biotech/pubs/fra/fra004.htm">Final Risk Assessment of the U.S. Environmental Protection Agency (EPA) (1997)</a> , a potential hazard of Escherichia coli K-12 and its derivative strains to human health should be addressed in terms of its potential to colonize the human intestinal tract and the production of a toxin. In this assessment, it was determined that E. coli K-12 does not pose a threat to human or animal health in terms of colonization; any concerns can be discarded because of this kind of bacteria’s poor ability to survive and mobilize plasmids ( to the native intestinal flora in murine models and even humans <a href="http://www.sciencemag.org/content/209/4454/391.full.pdf"> (Levy and Marshall, 1980).</p> |
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Latest revision as of 01:17, 25 September 2013
Safety
Organism Description
Escherichia coli is an Enterobacteria described by Bergey's Manual (1957). Escherichia is a Gram-negative rod which can be motile by peritrichous flagella or nonmotile. Escherichia is also a facultative anaerobe which has both a respiratory and a fermentative type of metabolism, and commonly occurs in the intestinal tract of humans and other animals. The strain E. coli K-12 is a debilitated strain which does not normally colonize the human intestine. It has also been shown to survive poorly in the environment, has a history of safe commercial use, and is not known to have adverse effects on microorganisms or plants.
Because of its wide use as a model organism in research in microbial genetics and physiology, and its use in industrial applications, E. coli K-12 is one of the most extensively studied microorganisms. As a result, these K-12 strains are well-characterized and should be expected to remain as pure cultures under standard microbiological practices. K-12 strains are distinguishable from other Escherichia.
According to the Final Risk Assessment of the U.S. Environmental Protection Agency (EPA) (1997) , a potential hazard of Escherichia coli K-12 and its derivative strains to human health should be addressed in terms of its potential to colonize the human intestinal tract and the production of a toxin. In this assessment, it was determined that E. coli K-12 does not pose a threat to human or animal health in terms of colonization; any concerns can be discarded because of this kind of bacteria’s poor ability to survive and mobilize plasmids ( to the native intestinal flora in murine models and even humans (Levy and Marshall, 1980).
