Team:HIT-Harbin

From 2013.igem.org

(Difference between revisions)
Line 1: Line 1:
-
<html>
+
{{HIT-Harbin/hidden}}
 +
<html>
<head>
<head>
-
<!-- Basic Page Needs
+
<!-- Basic Page Needs
-
  ================================================== -->
+
================================================== -->
-
<meta charset="utf-8">
+
<meta charset="utf-8">
-
<title>Sensation</title>
+
<title>Team:HIT-Harbin</title>
-
<!-- Mobile Specific
+
<!-- Mobile Specific
-
  ================================================== -->
+
================================================== -->
-
<meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=1">
+
<meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=1">
-
<!-- CSS
+
<!-- CSS
-
  ================================================== -->
+
================================================== -->
-
<link rel="stylesheet" type="text/css" href="https://2013.igem.org/Team:HIT-Harbin/css/style.css?action=raw&ctype=text/css">
+
<link rel="stylesheet" type="text/css" href="https://2013.igem.org/Team:HIT-Harbin/css/style.css?action=raw&ctype=text/css" />
-
+
-
<!-- Web Fonts
+
-
  ================================================== -->
+
-
<link href='http://fonts.googleapis.com/css?family=Open+Sans:400,700&amp;subset=latin,latin-ext' rel='stylesheet' type='text/css'>
+
-
+
-
<!-- JS
+
-
  ================================================== -->
+
-
<script type='text/javascript' src="http://ajax.googleapis.com/ajax/libs/jquery/1.7.1/jquery.min.js"></script>
+
-
<script type='text/javascript' src="js/twitter.js"></script>
+
-
<script type='text/javascript' src="js/custom.js"></script>
+
-
<script type='text/javascript' src="js/carousel.js"></script>
+
-
<script type='text/javascript' src="js/jquery.flexslider.js"></script>
+
-
<script type='text/javascript' src="js/shortcodes.js"></script>
+
-
<script type='text/javascript' src="js/imagebox.min.js"></script>
+
-
+
-
<!--[if lt IE 9]>
+
-
<script src="http://html5shim.googlecode.com/svn/trunk/html5.js"></script>
+
-
<![endif]-->
+
-
<!--[if (gte IE 6)&(lte IE 8)]>
+
<!-- Web Fonts
-
  <script src="js/selectivizr.js"></script>
+
================================================== -->
-
<![endif]-->
+
<link href='http://fonts.googleapis.com/css?family=Open+Sans:400,700&amp;subset=latin,latin-ext' rel='stylesheet' type='text/css'>
-
+
 
 +
<!-- JS
 +
================================================== -->
 +
<script type='text/javascript' src="http://ajax.googleapis.com/ajax/libs/jquery/1.7.1/jquery.min.js"></script>
 +
<script type='text/javascript' src="https://2013.igem.org/Team:HIT-Harbin/js/jquery.flexslider.js?action=raw&ctype=text/javascript"></script>
</head>
</head>
<body>
<body>
 +
<div id="header">
 +
 +
<!-- 960 Container -->
 +
<div class="container">
 +
<div class="four columns">
 +
<div id="logo"><a href="#"><img src="images/logo.png" alt="" class="address_contact" /></a></div>
 +
</div>
 +
 +
<div class="twelve columns">
 +
 +
<!-- Menu -->
 +
<div id="navigation">
 +
<ul>
 +
<li><a id="current" href="#">Home</a></li>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Team">Team</a>
 +
<ul>
 +
<li><a href="https://igem.org/Team.cgi?year=2013&team_name=HIT-Harbin">Official Team Profile</a></li>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Team">HIT IGEMers</a></li>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Team">Advisors</a></li>
 +
</ul>
 +
</li>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Project">Project</a>
 +
<ul>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Project">Overview</a></li>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Project">Background</a></li>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Project">Modeling</a></li>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Project">Attributions</a></li>
 +
</ul>
 +
</li>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Parts">Parts</a></li>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Notebook">Notebook</a></li>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Safety">Safety</a></li>
 +
<li><a href="https://2013.igem.org/Team:HIT-Harbin/Human_practices">Human Practice</a></li>
 +
</ul>
 +
</div>
 +
 +
</div>
 +
</div>
 +
</div>
 +
 +
<!-- 960 Container -->
 +
<div class="container">
 +
 +
<!-- Tagline -->
 +
<div class="sixteen columns">
 +
<div id="tagline">
 +
<p>Welcome to <a href="#">HIT-Harbin</a></p>
 +
</div>
 +
</div>
 +
 +
 +
</div>
 +
<!-- End 960 Container -->
 +
 +
<div class="container">
 +
 +
<div class="sixteen columns"><h2 class="related-title"><span>PROJECT DESCRIPTION</span></h2></div>
 +
 +
<div id="pro_des" style="text-align: center; font-weight: bold; font-size: large; color: #006600; padding:
 +
 +
5px;">
 +
Biological Proportional Operational MU-circuit
 +
</div>
 +
<div id="instructions" style="text-align: central; font-weight: normal; font-size: medium; color: #000088;
 +
 +
padding: 5px;">
 +
<p>In 1990s, Eric Mjolsness and several researchers developed the concept of genetic circuit from
 +
 +
electronic circuits, to facilitate research in modeling gene expression and regulation (Mjolsness, Sharp et al. 1991, McAdams and
 +
 +
Shapiro 1995, Reinitz and Sharp 1996, Sharp and Reinitz 1998). Upon the inspiration, Ron Weiss, a computer engineer of MIT,
 +
 +
constructed an AND-gate genetic circuit in 2001 (Weiss, Knight et al. 2001). Based on Weiss鈥? pioneering result, the team of Jeff
 +
 +
Hasty took IPTG (isopropyl 尾-D-1-Thiogalactopyranoside) and aTc (anhydrotetracycline) as the inputs and GFP (green fluorescent
 +
 +
protein) as the output; demonstrating the AND-gate circuit in a more lucid and applicable way (Hasty, McMillen et al. 2002). In
 +
 +
2005, to investigate the prospect of genetic circuit, Oliver Rackham proved that other kinds of logic circuits are feasible by
 +
 +
orthogonal topological structures (Rackham and Chin 2005). In 2013 iGEM, we inherit the idea of resembling electronic circuits. By
 +
 +
incorporating AND/OR gate and operational amplifier into one circuit, we create our device-Biological Proportional Operational Mu-
 +
 +
circuit (B-POM).</p>
 +
<br/>
 +
<p>In comparison with Weiss鈥? invention, B-POM has only one homogeneous or heterogeneous input and output.
-
<!-- Primary Page Layout
+
Besides, multiple magnitudes of input are distinguishable by the new circuit, and a given input corresponds to a certain output.
-
================================================== -->
+
-
+
-
<!-- Header -->
+
-
<div id="header">
+
-
+
-
<!-- 960 Container -->
+
-
<div class="container">
+
-
+
-
<!-- Logo -->
+
-
<div class="four columns">
+
-
<div id="logo"><a href="#"><img src="images/logo.png" alt="" /></a></div>
+
-
</div>
+
-
+
-
<div class="twelve columns">
+
-
+
-
<!-- Menu -->
+
-
<div id="navigation">
+
-
  <ul>
+
-
<li><a id="current" href="#">Home</a></li>
+
-
<li><a href="#">Features</a>
+
-
<ul>
+
-
<li><a href="about.html">About Us</a></li>
+
-
<li><a href="services.html">Services</a></li>
+
-
<li><a href="testimonials.html">Testimonials</a></li>
+
-
<li><a href="pricing_tables.html">Pricing Table</a></li>
+
-
<li><a href="shortcodes.html">Shortcodes</a></li>
+
-
<li><a href="text_columns.html">Text Columns</a></li>
+
-
<li><a href="blog_post.html">Single Blog Post</a></li>
+
-
<li><a href="#">3rd Level</a>
+
-
<ul>
+
-
<li><a href="#">Just an</a></li>
+
-
<li><a href="#">3rd Level</a></li>
+
-
<li><a href="#">Menu Example</a></li>
+
-
</ul>
+
-
</li>
+
-
</ul>
+
-
</li>
+
-
<li><a href="portfolio_3.html">Portfolio</a>
+
-
<ul>
+
-
<li><a href="portfolio_2.html">2 Columns</a></li>
+
-
<li><a href="portfolio_3.html">3 Columns</a></li>
+
-
<li><a href="portfolio_4.html">4 Columns</a></li>
+
-
<li><a href="single_project.html">Single Project</a></li>
+
-
</ul>
+
-
</li>
+
-
<li><a href="blog.html">Blog</a></li>
+
-
<li><a href="contact.html">Contact</a></li>
+
-
  </ul>
+
-
</div>
+
-
+
-
</div>
+
-
</div>
+
-
</div><!-- End Header -->
+
-
+
-
<!-- 960 Container -->
+
-
<div class="container">
+
-
+
-
<!-- Tagline -->
+
-
<div class="sixteen columns">
+
-
<div id="tagline">
+
-
<p>Welcome to <a href="#">Sensation</a> Clean & Responsive HTML Template.</p>
+
-
<p>This intro text can be modified and is a good way to say hello to the visitor.</p>
+
-
</div>
+
-
</div>
+
-
+
-
<!-- Slider -->
+
-
<div class="sixteen columns">
+
-
<div class="flexslider home">
+
-
<ul class="slides">
+
-
<li>
+
Moreover, whereas general genetic circuits are vulnerable to the noise of cellular background, B-POM seems more interference-free,
-
<img src="images/img_slider_01.jpg" alt="" />
+
-
<div class="slider-caption">
+
-
<h3>This is a caption</h3>
+
-
<p>Donec scelerisque aliquet mi, non venenatis urnas iaculis. Utea id nila ante. Cras est massa, interdum ateal imperdiet etean, gravida eu quame. Aeneana volutpat hendrerit posuere.</p>
+
-
</div>
+
-
</li>
+
-
<li>
+
implicating the prominent stability of our device.</p>
-
<img src="images/img_slider_02.jpg" alt="" />
+
<br/>
-
<div class="slider-caption-2">
+
<p>In applications, we plan to enhance Bio-electric Interface, the device designed by 2012 Edinburg iGEM team. If the
-
<h3>We're The Best</h3>
+
-
<p>It�s very easy to be different, but very difficult to be better.</p>
+
-
</div>
+
-
</li>
+
-
+
-
<li>
+
-
<img src="images/img_slider_03.jpg" alt="" />
+
-
<div class="slider-caption">
+
-
<h3>This is a caption</h3>
+
-
<p>Utea id nila ante cras est massa, interdum ateal imperdiet etean, gravida eu quameas aeneana volutpat hendrerit posuere lipsum dolor sit amet.</p>
+
-
</div>
+
-
</li>
+
-
+
-
</ul>
+
-
</div>
+
-
</div>
+
-
+
-
<div class="sixteen columns" id="divider"></div>
+
-
+
-
<!-- 1/3 Columns -->
+
-
<div class="one-third column">
+
-
<div class="feature">
+
-
<div class="feature-circle green">1</div>
+
-
<div class="feature-description">
+
-
<h4>Modern & Clean Design</h4>
+
-
Proin iaculis purus consequat sem cursus digni ssim. Donec porttitor entume suscipit. Aenean rhoncus posuere odio in tincidunt.
+
-
</div>
+
-
</div>
+
-
</div>
+
-
+
-
<!-- 1/3 Columns -->
+
-
<div class="one-third column">
+
-
<div class="feature">
+
-
<div class="feature-circle gray">2</div>
+
-
<div class="feature-description">
+
-
<h4>Easy to Customize</h4>
+
-
Nam aliquam volutpat leo vel lorem bibendum. Nuncea elit purusa, tempus pulvinar rhoncus egesta vel nibh volutpat leo.
+
-
</div>
+
-
</div>
+
-
</div>
+
-
+
-
<!-- 1/3 Columns -->
+
-
<div class="one-third column">
+
-
<div class="feature">
+
-
<div class="feature-circle gray">3</div>
+
-
<div class="feature-description">
+
-
<h4>Responsive Template</h4>
+
-
Fusce porttitor turpis quis urna molestie cons equat. Nam felis purus, tincidunt sed dapibus ugravida fusce et magna libero.
+
-
</div>
+
-
</div>
+
-
</div>
+
-
<!-- End Features -->
+
-
</div>
+
-
<!-- End 960 Container -->
+
-
<!-- 960 Container -->
+
input is biochemical signal molecules and the output become electrons, B-POM can be coupled with Bio-electric Interface, that
-
<div class="container">
+
-
<div class="sixteen columns"><h2 class="related-title"><span>Recent Work</span></h2></div>
+
ephemeral processes in cells will be precisely measurable by simple electronic methods and analyzable by computer. B-POM is also
-
+
-
<!-- Project - 1/3 Columns -->
+
-
<div class="one-third column">
+
-
<div class="item">
+
-
<div class="item-img">
+
-
<a href="images/img_single_project_01.jpg" rel="imagebox[gallery]" title="Donec seid odio dui. Nullalit libero, alea pharetra augue."><img src="images/img_project_01.jpg" alt=""/><div class="overlay zoom"></div></a>
+
-
</div>
+
-
<div class="item-meta">
+
-
<h4><a href="single_project.html">Architecture in Melbourne</a></h4>
+
-
Your custom portolio item short description.
+
-
</div>
+
-
</div>
+
-
</div>
+
-
+
-
<!-- Project - 1/3 Columns -->
+
-
<div class="one-third column">
+
-
<div class="item">
+
-
<div class="item-img">
+
-
<a href="single_project.html"><img src="images/img_project_02.jpg" alt=""/><div class="overlay link"></div></a>
+
-
</div>
+
-
<div class="item-meta">
+
-
<h4><a href="single_project.html">Architecture Design</a></h4>
+
-
Ante venenatis dapibus posuere velit aliquet.
+
-
</div>
+
-
</div>
+
-
</div>
+
-
+
-
<!-- Project - 1/3 Columns -->
+
-
<div class="one-third column">
+
-
<div class="item">
+
-
<div class="item-img">
+
-
<a href="single_project.html"><img src="images/img_project_03.jpg" alt=""/><div class="overlay link"></div></a>
+
-
</div>
+
-
<div class="item-meta">
+
-
<h4><a href="single_project.html">Building / Architecture</a></h4>
+
-
Nullam dictum felis eu pede mollis pretium.
+
-
</div>
+
-
</div>
+
-
</div>
+
-
+
-
</div>
+
-
<!-- End 960 Container -->
+
 +
helpful in yoghurt producing, where the control of pH is inaccurate. When B-POM is transplanted into yoghurt-producing bacteria,
-
<!-- 960 Container -->
+
let hydrogen ions be the input and lacR be the output, and select the proper B-POM parameters, then the pH will be steady around
-
<div class="container">
+
-
<div class="twelve columns">
+
5.5. In short, our inspired and reliable device is promising in various fields.</p>
-
+
</div>
-
<!-- Title -->
+
<div align="center">
-
<h2 class="related-title"><span>Latest From Blog</span></h2>
+
<img src="https://static.igem.org/mediawiki/2013/c/c6/HIT-Harbin_Project_Schematic.png" />
 +
<h3>Figure : A Schematic of the Biological Proportional Operational MU-circuit </h3>
 +
</div>
 +
</div>
 +
</div>
-
<!-- Blog Post - 1/4 Columns -->
 
-
<div class="four columns" style="padding-left: 0; margin-left:0">
 
-
<div class="item">
 
-
<div class="item-img img-blog">
 
-
<a href="blog_post.html"><img src="images/img_blog_01.jpg" alt=""/><div class="overlay link"></div></a>
 
-
</div>
 
-
<div class="item-meta meta-blog">
 
-
<h4><a href="blog_post.html">Tuscany Landscape</a></h4>
 
-
<span>March 16, 2012 / 12 comments</span>
 
-
<p>Nullam dictum felis eu pede molis pretium ianteger tincidunt cras.</p>
 
-
</div>
 
-
</div>
 
-
</div>
 
-
 
-
<!-- Blog Post - 1/4 Columns -->
 
-
<div class="four columns">
 
-
<div class="item">
 
-
<div class="item-img img-blog">
 
-
<a href="blog_post.html"><img src="images/img_blog_02.jpg" alt=""/><div class="overlay link"></div></a>
 
-
</div>
 
-
<div class="item-meta meta-blog">
 
-
<h4><a href="blog_post.html">Mountain Landscape</a></h4>
 
-
<span>March 16, 2012 / 12 comments</span>
 
-
<p>Nullam dictum felis eu pede molis pretium ianteger tincidunt cras</p>
 
-
</div>
 
-
</div>
 
-
</div>
 
-
 
-
<!-- Blog Post - 1/4 Columns -->
 
-
<div class="four columns" style="padding-right: 0; margin-right:0">
 
-
<div class="item">
 
-
<div class="item-img img-blog">
 
-
<a href="blog_post.html"><img src="images/img_blog_03.jpg" alt=""/><div class="overlay link"></div></a>
 
-
</div>
 
-
<div class="item-meta meta-blog">
 
-
<h4><a href="blog_post.html">Vintage Beach</a></h4>
 
-
<span>March 16, 2012 / 12 comments</span>
 
-
<p>Nullam dictum felis eu pede molis pretium ianteger tincidunt cras</p>
 
-
</div>
 
-
</div>
 
-
</div>
 
-
 
-
</div>
 
-
 
-
<!-- Testimonials - 1/4 Columns -->
 
-
<div class="four columns">
 
-
<h2 class="related-title"><span>Testimonials</span></h2>
 
-
 
-
<!-- Testimonials Carousel -->
 
-
<div class="testimonials-carousel">
 
-
<ul class="carousel">
 
-
 
-
<li class="testimonial">
 
-
<div class="testimonials">Posuere erat a ante venenatis dapibus posuere velit aliquet. Duis llis, est non coeammodo luctus, nisi erat porttitor ligula, egeteas laciniato odiomo sem.</div>
 
-
<div class="testimonials_bg"></div>
 
-
<div class="testimonials_author">Michael, <span>Flash Developer</span></div>
 
-
</li>
 
-
 
-
<li class="testimonial">
 
-
<div class="testimonials">Integer eu libero sit amet nisl vestibulum semper. Fusce nec porttitor massa. In nec neque elit. Curabitur malesuada ligula vitae purus ornare onec etea magna diam varius.</div>
 
-
<div class="testimonials_bg"></div>
 
-
<div class="testimonials_author">John, <span>Web Developer</span></div>
 
-
</li>
 
-
 
-
<li class="testimonial">
 
-
<div class="testimonials">Cras sed odio est, sit amet porttitor elit. Vestibulum elementum erat vitae ante venenatis cursus scelerisque quam vel nibh imperdiet vitae porta lorem posuere.</div>
 
-
<div class="testimonials_bg"></div>
 
-
<div class="testimonials_author">Peter, <span>Project Manager</span></div>
 
-
</li>
 
-
 
-
<li class="testimonial">
 
-
<div class="testimonials">Elementum erat vitae ante venenatis dapibus. Maecenas cursus scelerisque quam vel nibh imperdiet vitae porta lorem posuere.</div>
 
-
<div class="testimonials_bg"></div>
 
-
<div class="testimonials_author">Kathy, <span>Art Director</span></div>
 
-
</li>
 
-
 
-
</ul>
 
-
</div>
 
-
 
-
</div>
 
-
 
-
</div>
 
-
<!-- /End 960 Container -->
 
-
<!-- Footer -->
+
<!-- Back To Top Button -->
-
<div id="footer">
+
<div id="backtotop"><a href="#"></a></div>
-
+
-
<!-- 960 Container -->
+
-
<div class="container">
+
-
+
-
<!--  Text Widget - 1/4 Columns -->
+
-
<div class="four columns">
+
-
<div id="footer-logo"><img src="images/logo.png" alt="" /></div>
+
-
<p>Sensation is an incredibly beautiful responsive HTML Template. Nunceasle ullamacorper comodore semas placea.</p>
+
-
<ul class="social">
+
-
<li class="facebook"><a href="#"></a></li>
+
-
<li class="twitter"><a href="#"></a></li>
+
-
<li class="vimeo"><a href="#"></a></li>
+
-
<li class="linked"><a href="#"></a></li>
+
-
<li class="flickr"><a href="#"></a></li>
+
-
  </ul>
+
-
</div>
+
-
+
-
<!--  Contact - 1/4 Columns -->
+
-
<div class="four columns">
+
-
<h4>Contact Details</h4>
+
-
<div class="address"><img style="padding-top: 1px" src="images/address.png" alt="" /><strong>Address:</strong> Aleje Jerozolimskie 30, Warsaw, Poland</div>
+
-
<div class="address"><img style="padding-top: 1px" src="images/phone.png" alt=""/><strong>Phone:</strong> +44 (0) 560-655-995</div>
+
-
<div class="address"><img style="padding-top: 3px" src="images/mail.png" alt=""/><strong>Email:</strong><a href="#"> contact@sensation.com</a></div>
+
-
</div>
+
-
+
-
<!--  Latest Tweets - 1/4 Columns -->
+
-
<div class="four columns">
+
-
<h4>Latest Tweets</h4>
+
-
<ul id="twitter"></ul>
+
-
<script type="text/javascript">
+
-
jQuery(document).ready(function($){
+
-
$.getJSON('http://api.twitter.com/1/statuses/user_timeline/envato.json?count=2&amp;callback=?', function(tweets){
+
-
$("#twitter").html(tz_format_twitter(tweets));
+
-
}); });
+
-
</script>
+
-
<div class="clearfix"></div>
+
-
</div>
+
-
+
-
<!--  photo Stream - 1/4 Columns -->
+
-
<div class="four columns">
+
-
<h4>Photo Stream</h4>
+
-
<div class="flickr-widget">
+
-
<script type="text/javascript" src="http://www.flickr.com/badge_code_v2.gne?count=8&amp;display=latest&amp;size=s&amp;layout=x&amp;source=user&amp;user=36587311@N08"></script>
+
-
<div class="clearfix"></div>
+
-
</div>
+
-
</div>
+
-
+
-
</div><!-- End 960 Container -->
+
-
</div>
+
-
+
-
<!--  Footer - Copyright-->
+
-
<div id="footer_bottom">
+
-
<!-- 960 Container -->
+
-
<div class="container">
+
-
+
-
<div class="eight columns">
+
-
<div class="copyright">?Copyright 2012 by <span>Sensation</span>. All Rights Reserved.</div>
+
-
</div>
+
-
+
-
<div class="eight columns">
+
-
<div class="author-info">Template by <a href="#">Vasterad</a> for <span>ThemeForest</span>.</div>
+
-
</div>
+
-
+
-
</div><!-- End 960 Container -->
+
-
</div>
+
-
+
-
<!-- Back To Top Button -->
+
-
<div id="backtotop"><a href="#"></a></div>
+
-
+
-
<!-- Imagebox Build -->
+
-
<script src="js/imagebox.build.js"></script>
+
-
+
-
<div style="display:none"><script src='http://v7.cnzz.com/stat.php?id=155540&web_id=155540' language='JavaScript' charset='gb2312'></script></div>
+
</body>
</body>
</html>
</html>

Revision as of 06:26, 22 September 2013

Team:HIT-Harbin

Welcome to HIT-Harbin

Biological Proportional Operational MU-circuit

In 1990s, Eric Mjolsness and several researchers developed the concept of genetic circuit from electronic circuits, to facilitate research in modeling gene expression and regulation (Mjolsness, Sharp et al. 1991, McAdams and Shapiro 1995, Reinitz and Sharp 1996, Sharp and Reinitz 1998). Upon the inspiration, Ron Weiss, a computer engineer of MIT, constructed an AND-gate genetic circuit in 2001 (Weiss, Knight et al. 2001). Based on Weiss鈥? pioneering result, the team of Jeff Hasty took IPTG (isopropyl 尾-D-1-Thiogalactopyranoside) and aTc (anhydrotetracycline) as the inputs and GFP (green fluorescent protein) as the output; demonstrating the AND-gate circuit in a more lucid and applicable way (Hasty, McMillen et al. 2002). In 2005, to investigate the prospect of genetic circuit, Oliver Rackham proved that other kinds of logic circuits are feasible by orthogonal topological structures (Rackham and Chin 2005). In 2013 iGEM, we inherit the idea of resembling electronic circuits. By incorporating AND/OR gate and operational amplifier into one circuit, we create our device-Biological Proportional Operational Mu- circuit (B-POM).


In comparison with Weiss鈥? invention, B-POM has only one homogeneous or heterogeneous input and output. Besides, multiple magnitudes of input are distinguishable by the new circuit, and a given input corresponds to a certain output. Moreover, whereas general genetic circuits are vulnerable to the noise of cellular background, B-POM seems more interference-free, implicating the prominent stability of our device.


In applications, we plan to enhance Bio-electric Interface, the device designed by 2012 Edinburg iGEM team. If the input is biochemical signal molecules and the output become electrons, B-POM can be coupled with Bio-electric Interface, that ephemeral processes in cells will be precisely measurable by simple electronic methods and analyzable by computer. B-POM is also helpful in yoghurt producing, where the control of pH is inaccurate. When B-POM is transplanted into yoghurt-producing bacteria, let hydrogen ions be the input and lacR be the output, and select the proper B-POM parameters, then the pH will be steady around 5.5. In short, our inspired and reliable device is promising in various fields.

Figure : A Schematic of the Biological Proportional Operational MU-circuit