Team:MIT

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{{MIT-style}}{{MIT-header2}}<html>
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document.title = "MIT iGEM - Home";
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You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
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You <strong>MUST</strong> have all of the pages listed in the menu below with the names specified. PLEASE keep all of your pages within your teams namespace. 
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<img src="https://static.igem.org/mediawiki/2013/0/05/Front_page_overview.png" width="100%" >
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<h1>Motivation</h1>
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<p>This summer, the 2013 MIT iGEM team worked to engineer exosome mediated cell-cell communication. In vivo cell-cell communication is vital for pattern formation, organ development, coordinated responses to environmental changes, and the maintenance of an organism (Bacchus, 2012)</p>
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<h1>Our Contribution</h1>
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<p>We demonstrated that exosomes can be engineered to transport protein and miRNA signals of interest. These signals remain functional and can actuate a response in a receiver cell. By co-culturing sender and receiver cells, we have demonstrated exosome mediated unidirectional cell-cell communication. </p>
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<h1>Our Vision</h1>
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<p> Exosomes provide an innovative means of engineering cell-cell communication that can have exciting application in drug testing and development. Tissue engineers are currently working to develop organoids small tissue structures that recapitulate the behavior of organs in vitro  (Lancaster, 2013). Organoids can be used to test drugs more rigorously in a human-like context rather than relying solely on animal models. Thus drugs can be developed with a better understanding of their toxicity and efficacy. These multicellular structures require cell-cell communication, and our exosome mediated communication system could serve as an enabling technology for organoid development<p>
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<p> Lancaster, Madeline et al. Cerebral organoids model human brain development and microcephaly. Nature 501, 373–379 (2013)
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Bacchus, William et al. Synthetic two-way communication between mammalian cells. Nat. Biotechnol. 30, 991–996 (2012)
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</p>
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<h1>Sponsors</h3>
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|You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing.
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<ul id="leftsponsors" style="text-align:center">
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|[[Image:MIT_logo.png|200px|right|frame]]
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  <li><a href="http://www.eecs.mit.edu/"><img src='https://static.igem.org/mediawiki/2011/2/22/Mit-eecs.jpg' /></a></li>
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  <li><a href="http://web.mit.edu/be/"><img src='https://static.igem.org/mediawiki/2011/a/a7/Mit-be.jpg' /></a></li>
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  <li><a href="http://web.mit.edu/cheme/"><img src='https://static.igem.org/mediawiki/2012/0/01/Cheme.png' style="width:175px"></a></li>
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''Tell us more about your project. Give us background. Use this as the abstract of your project. Be descriptive but concise (1-2 paragraphs)''
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  <li><a href="https://2012.igem.org/Main_Page"><img src='https://static.igem.org/mediawiki/igem.org/d/de/IGEM_basic_Logo_stylized.png' style="width:175px;"></a></li>
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|[[Image:MIT_team.png|right|frame|Your team picture]]
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|align="center"|[[Team:MIT | Team MIT]]
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<ul id="centersponsors" style="text-align:center">
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  <li><a href="http://www.geneious.com"><img src='https://static.igem.org/mediawiki/2011/6/65/Mit-geneious.jpg' /></a></li>
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  <li><a href="http://www.genewiz.com"><img src='https://static.igem.org/mediawiki/2011/3/33/Mit-genewiz.jpg' /></a></li>
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  <li><a href="http://www.addgene.org/"><img src='https://static.igem.org/mediawiki/2012/5/58/Addgene.png' /></a></li>
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  <li><a href="http://www.ll.mit.edu/"><img width="100%" src='https://static.igem.org/mediawiki/2013/6/6b/LL_Logo_blue.jpg' /></a></li>
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<li><a href="http://www.qiagen.com/"><img width="70%" src='https://static.igem.org/mediawiki/2013/0/0c/Qiagen-logo.GIF' /></a></li>
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<li><a href="http://gen9bio.com/"><img width="100%" src='https://static.igem.org/mediawiki/2013/3/33/Gen9logo.png' /></a></li>
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<ul id="rightsponsors" style="text-align:center">
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!align="center"|[[Team:MIT|Home]]
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  <li><a href="http://ebics.net"><img src='https://static.igem.org/mediawiki/igem.org/0/0d/EBICS_logo.JPG' style="width:175px"></a></li>
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!align="center"|[[Team:MIT/Team|Team]]
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  <li><a href="http://ehs.mit.edu/site/"><img src='https://static.igem.org/mediawiki/2012/5/52/Ehs_logo.jpg'></a></li>
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!align="center"|[https://igem.org/Team.cgi?year=2013&team_name=MIT Official Team Profile]
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  <li><a href="http://www.monsanto.com/Pages/default.aspx"><img src='https://static.igem.org/mediawiki/2012/1/18/Monsanto.png'></a></li>
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!align="center"|[[Team:MIT/Project|Project]]
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  <li><a href="http://www.idtdna.com/site"><img src='https://static.igem.org/mediawiki/2012/4/41/Idt2.png'></a></li>
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!align="center"|[[Team:MIT/Parts|Parts Submitted to the Registry]]
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  <li><a href="http://www.thirdrockventures.com/"><img width="100%" src='https://static.igem.org/mediawiki/2013/8/8d/Thirdrock.jpg'></a></li>
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!align="center"|[[Team:MIT/Modeling|Modeling]]
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  <li><a href="http://www.alnylam.com/"><img width="100%" src='https://static.igem.org/mediawiki/2013/c/c8/Alnylam-Pharmaceuticals-Inc-ALNY.png'></a></li>
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!align="center"|[[Team:MIT/Notebook|Notebook]]
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</ul>
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!align="center"|[[Team:MIT/Safety|Safety]]
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!align="center"|[[Team:MIT/Attributions|Attributions]]
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Latest revision as of 03:53, 29 October 2013

iGEM 2012

Motivation

This summer, the 2013 MIT iGEM team worked to engineer exosome mediated cell-cell communication. In vivo cell-cell communication is vital for pattern formation, organ development, coordinated responses to environmental changes, and the maintenance of an organism (Bacchus, 2012)

Our Contribution

We demonstrated that exosomes can be engineered to transport protein and miRNA signals of interest. These signals remain functional and can actuate a response in a receiver cell. By co-culturing sender and receiver cells, we have demonstrated exosome mediated unidirectional cell-cell communication.

Our Vision

Exosomes provide an innovative means of engineering cell-cell communication that can have exciting application in drug testing and development. Tissue engineers are currently working to develop organoids small tissue structures that recapitulate the behavior of organs in vitro (Lancaster, 2013). Organoids can be used to test drugs more rigorously in a human-like context rather than relying solely on animal models. Thus drugs can be developed with a better understanding of their toxicity and efficacy. These multicellular structures require cell-cell communication, and our exosome mediated communication system could serve as an enabling technology for organoid development

Lancaster, Madeline et al. Cerebral organoids model human brain development and microcephaly. Nature 501, 373–379 (2013) Bacchus, William et al. Synthetic two-way communication between mammalian cells. Nat. Biotechnol. 30, 991–996 (2012)

Sponsors

Retrieved from "http://2013.igem.org/Team:MIT"