Team:UIUC Illinois

From 2013.igem.org

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<li id="button"><a href="#"><a href="#" class="button">About</a></dt>
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<li id="services"><a href="#" class="button">Achivements</a></dt>
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<li id="portfolio"><a href="#" class="button">Impact</a></dt>
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  <h2 class="titleofselection">Abstract</h2>
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  <p class="text">Cardiovascular disease (CVD) has been
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    the leading cause of death in the United
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    States for over twenty years and is
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    becoming a severe global health issue.
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    CVD is highly associated with the
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    buildup of plaque in arteries, a disease
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    known as Atherosclerosis. Trimethylamine
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    N-oxide (TMAO) is a known proatherogenic
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    substance, and is abundant in
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    carnivorous humans and those who consume
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    energy drinks. It is the goal of the
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    University of Illinois at Urbana
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    Champaign (UIUC) iGEM Team to lower the
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    amount of TMAO found in such individuals
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    and therefore reduce the risk of
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    atherosclerosis for those afflicted.TMAO
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    is produced when the gut microbiota
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    process the amino acid derivatives
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    L-carnitine and choline. These
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    metabolites are abundant in red meats
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    and energy drinks, and are important
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    bodily compounds; however, humans are
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    intrinsically capable of producing the
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    necessary amounts. When these substances
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    are consumed, specific gut bacteria
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    convert L-carnitine and choline into a
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    harmful byproduct trimethylamine (TMA.)
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    To protect itself, the liver oxidizes
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    TMA into TMAO.
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    We are creating a probiotic to
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    outcompete the gut bacteria for
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        <img src="images/logo1.png" width="200" height="78" alt="UIUC iGEM" class="left" />
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    L-carnitine and choline to effectively
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    lower and ultimately remove the
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    atherogenic activity caused by TMAO.
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    Pseudomonas aeruginosa is a bacterium
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    with novel adaptations that enable it to
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    uptake L-carnitine as a sole source of
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    carbon and nitrogen. These genes have
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    been selected for and are being tested
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        Cardiovascular disease (CVD) has been the leading cause of death in the United States for over twenty years and is becoming a severe global health issue. CVD is highly associated with the buildup of plaque in arteries, a disease known as Atherosclerosis. Trimethylamine N-oxide (TMAO) is a known proatherogenic substance, and is abundant in carnivorous humans and those who consume energy drinks. It is the goal of the University of Illinois at Urbana Champaign (UIUC) iGEM Team to lower the amount of TMAO found in such individuals and therefore reduce the risk of atherosclerosis for those afflicted.TMAO is produced when the gut microbiota process the amino acid derivatives L-carnitine and choline. These metabolites are abundant in red meats and energy drinks, and are important bodily compounds; however, humans are intrinsically capable of producing the necessary amounts. When these substances are consumed, specific gut bacteria convert L-carnitine and choline into a harmful byproduct trimethylamine (TMA.) To protect itself, the liver oxidizes TMA into TMAO. We are creating a probiotic to outcompete the gut bacteria for L-carnitine and choline to effectively lower and ultimately remove the atherogenic activity caused by TMAO. Pseudomonas aeruginosa is a bacterium with novel adaptations that enable it to uptake L-carnitine as a sole source of carbon and nitrogen. These genes have been selected for and are being tested in various Escherichia coli.
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    in various Escherichia coli. </p>
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<div id="sponsors"> Sponsors </div>
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          <div class="AccordionPanelTab">Home</div>
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          <div class="AccordionPanelContent">This is where the home content should go. Ideally, this text should be meaningful and instill hope into the reader.</div>
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          <div class="AccordionPanelTab">About</div>
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          <div class="AccordionPanelContent">This is where the about content should go. Ideally, this text should be meaningful and instill hope into the reader.</div>
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        </div>
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          <div class="AccordionPanelTab">Project</div>
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          <div class="AccordionPanelContent">This is where the project content should go. Ideally, this text should be meaningful and instill hope into the reader.</div>
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          <div class="AccordionPanelTab">Medal Requirements</div>
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          <div class="AccordionPanelTab">Human Practices</div>
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          <div class="AccordionPanelContent">This is where the human practices content should go. Ideally, this text should be meaningful and instill hope into the reader.</div>
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        </div>
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        <div class="AccordionPanel">
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          <div class="AccordionPanelTab">Safety</div>
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          <div class="AccordionPanelContent">This is where the safety content should go. Ideally, this text should be meaningful and instill hope into the reader.</div>
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Revision as of 07:02, 1 September 2013

<head> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <title>iGEM Index</title> <link href="SpryAssets/SpryAccordion.css" rel="stylesheet" type="text/css" /> <script src="SpryAssets/SpryAccordion.js" type="text/javascript"></script> </head> <body> 

       <img src="images/logo1.png" width="200" height="78" alt="UIUC iGEM" class="left" /> 
       <img src="images/IGEM_basic_Logo_stylized.png" width="141.467" height="114.8" alt="iGEM" class="right" />
<img src="images/smiling fox.jpg" width="700" height="204" /> 
       Cardiovascular disease (CVD) has been the leading cause of death in the United States for over twenty years and is becoming a severe global health issue. CVD is highly associated with the buildup of plaque in arteries, a disease known as Atherosclerosis. Trimethylamine N-oxide (TMAO) is a known proatherogenic substance, and is abundant in carnivorous humans and those who consume energy drinks. It is the goal of the University of Illinois at Urbana Champaign (UIUC) iGEM Team to lower the amount of TMAO found in such individuals and therefore reduce the risk of atherosclerosis for those afflicted.TMAO is produced when the gut microbiota process the amino acid derivatives L-carnitine and choline. These metabolites are abundant in red meats and energy drinks, and are important bodily compounds; however, humans are intrinsically capable of producing the necessary amounts. When these substances are consumed, specific gut bacteria convert L-carnitine and choline into a harmful byproduct trimethylamine (TMA.) To protect itself, the liver oxidizes TMA into TMAO. We are creating a probiotic to outcompete the gut bacteria for L-carnitine and choline to effectively lower and ultimately remove the atherogenic activity caused by TMAO. Pseudomonas aeruginosa is a bacterium with novel adaptations that enable it to uptake L-carnitine as a sole source of carbon and nitrogen. These genes have been selected for and are being tested in various Escherichia coli.

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