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| - | <div id="page-container">
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| - | <div id="logo"> <h1 class="titleofselection"></h1> </div>
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| - | <div id="sidebar">
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| - | <div id="main-nav">
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| - | <ul class="myClass">
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| - | <li id="button"><a href="#"><a href="#" class="button">About</a></dt>
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| - | <li id="services"><a href="#" class="button">Achivements</a></dt>
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| - | <li id="portfolio"><a href="#" class="button">Impact</a></dt>
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| - | <li id="contact"><a href="#" class="button">Outreach</a></dt>
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| - | <li id="button"><a href="#" class="button">Pictures</a></dt>
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| - | <li id="services"><a href="#" class="button">Project</a></dt>
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| - | <li id="portfolio"><a href="#" class="button">Safety</a></dt>
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| - | </ul>
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| - | </div>
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| - | </div>
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| - | <div id="picture"><img src="Images/exportedforsite.png" width="839" height="296"></div>
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| - | <div id="abstract">
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| - | <h2 class="titleofselection">Abstract</h2>
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| - | <p class="text">Cardiovascular disease (CVD) has been
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| - | the leading cause of death in the United
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| - | States for over twenty years and is
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| - | becoming a severe global health issue.
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| - | CVD is highly associated with the
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| - | buildup of plaque in arteries, a disease
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| - | known as Atherosclerosis. Trimethylamine
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| - | N-oxide (TMAO) is a known proatherogenic
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| - | substance, and is abundant in
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| - | carnivorous humans and those who consume
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| - | energy drinks. It is the goal of the
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| - | University of Illinois at Urbana
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| - | Champaign (UIUC) iGEM Team to lower the
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| - | amount of TMAO found in such individuals
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| - | and therefore reduce the risk of
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| - | atherosclerosis for those afflicted.TMAO
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| - | is produced when the gut microbiota
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| - | process the amino acid derivatives
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| - | L-carnitine and choline. These
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| - | metabolites are abundant in red meats
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| - | and energy drinks, and are important
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| - | bodily compounds; however, humans are
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| - | intrinsically capable of producing the
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| - | necessary amounts. When these substances
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| - | are consumed, specific gut bacteria
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| - | convert L-carnitine and choline into a
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| - | harmful byproduct trimethylamine (TMA.)
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| - | To protect itself, the liver oxidizes
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| - | TMA into TMAO.
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| - | We are creating a probiotic to
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| - | outcompete the gut bacteria for
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| - | L-carnitine and choline to effectively
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| - | lower and ultimately remove the
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| - | atherogenic activity caused by TMAO.
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| - | Pseudomonas aeruginosa is a bacterium
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| - | with novel adaptations that enable it to
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| - | uptake L-carnitine as a sole source of
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| - | carbon and nitrogen. These genes have
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| - | been selected for and are being tested
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| - | in various Escherichia coli. </p>
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| - | </h2> </div>
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| - | <div id="sponsors"> Sponsors </div>
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| - | </div>
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| | </body> | | </body> |
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| | </html> | | </html> |
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