Team:UT Dallas/Project

From 2013.igem.org

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Harmful bacteria, such as Streptococcus mutans, live in the mouth and convert sucrose into lactic acid and fructose/glucose.  The lactic acid creates acidic conditions in the mouth, leading to tooth enamel decay.  The fructose/glucose combination forms a sticky polysaccharide called dextran.  This molecule is responsible for dental plaque and creates the optimal platform for populous colonies of bacteria on the surface of the teeth.  Streptococcus mutans has been determined to be the primary contributor to dental plaque and cavities.<br><br>
Harmful bacteria, such as Streptococcus mutans, live in the mouth and convert sucrose into lactic acid and fructose/glucose.  The lactic acid creates acidic conditions in the mouth, leading to tooth enamel decay.  The fructose/glucose combination forms a sticky polysaccharide called dextran.  This molecule is responsible for dental plaque and creates the optimal platform for populous colonies of bacteria on the surface of the teeth.  Streptococcus mutans has been determined to be the primary contributor to dental plaque and cavities.<br><br>
<center><img src='https://static.igem.org/mediawiki/2013/b/b8/Streptococcus_mutans_01.jpg' height=400 width=500></center><br>
<center><img src='https://static.igem.org/mediawiki/2013/b/b8/Streptococcus_mutans_01.jpg' height=400 width=500></center><br>
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Our project entails selectively fighting off this bacteria through 3 different ways:
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<li>CscR and FruR</li>
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<li>Competence Stimulating Protein, and/or</li>
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<li>Destroying the biofilm upon which the bacteria grows through NspC, Norspermidine.</li><br> 
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</div>
</div>

Revision as of 08:24, 27 September 2013

Part 1
Part 2
Part 3
Overview

Harmful bacteria, such as Streptococcus mutans, live in the mouth and convert sucrose into lactic acid and fructose/glucose. The lactic acid creates acidic conditions in the mouth, leading to tooth enamel decay. The fructose/glucose combination forms a sticky polysaccharide called dextran. This molecule is responsible for dental plaque and creates the optimal platform for populous colonies of bacteria on the surface of the teeth. Streptococcus mutans has been determined to be the primary contributor to dental plaque and cavities.


Our project entails selectively fighting off this bacteria through 3 different ways:
  • CscR and FruR
  • Competence Stimulating Protein, and/or
  • Destroying the biofilm upon which the bacteria grows through NspC, Norspermidine.