Revision as of 23:05, 4 October 2013

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We are proud to participate in IGEM 2013 and are looking forward to present
Taxi.Coli - smart drug delivery

Please also visit our Facebook page!

Register the team, have fun in the competition.
iGEM 2013 Judging form.
Description of the team's project using the iGEM wiki and the team's parts using the Registry of Standard Biological Parts.
Present a poster and talk at the iGEM Jamboree.
Document at least one new standard BioBrick Part and submit it to the Registry + a new application and documentation of a previously existing BioBrick part in the Registry

Experimentally validate that at least one new BioBrick Part of your own design and construction works as expected.
Document the characterization of this part and submit this new part to the iGEM Parts Registry
Implications for the environment, security, safety and ethics and/or ownership and sharing. Describe one or more ways in which these or other broader implications have been taken into consideration in the design and execution of your project.

Improve the function of an existing BioBrick Part or Device
Outline and detail a new approach to an issue of Human Practice in synthetic biology as it relates to your project, such as safety, security, ethics, or ownership, sharing, and innovation.

Figure1: Many thank to our sponsor: AC IMMUNE

Figure1: Many thank to our sponsor: EPFL and our faculty of Life Sciences

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 '''Taxi.Coli - smart drug delivery'''
-The team’s vision is to build a biosynthetic drug delivery concept. The key word of this project is “adaptability”. Our goal is to explore a way of using E.coli as a highly modular carrier, opening the gate to several applications and alternatives in disease treatments. Using the principles of synthetic biology, we engineered a gelatinase secreting E.coli able to bind gelatin nanoparticles using a biotin-streptavidin interaction and release their cargo in a corresponding location. The drug delivery system is built in three parts: 1) the nanoparticles binding and 2) the environment sensing that 3) triggers the gelatinase release of the engineered E.coli, liberating the content of the nanoparticle.
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