Design & Device

Promoter: 4 copies of NFκB gene

On the basis of NF-κB signaling pathway and its feedback loop dynamics, we provided a device: A high-throughput drug screening system. The system is used to screen targeted drugs in NF-κB signaling pathway and lasts even longer. Natrually, we could estimate whether the kind of drug is good or not.


NF-κB is a DNA binding protein, which means that the dimer could recognize a certain gene sequence and bind with it. Thus, we designed a four coupies of NF-κB gene sequence as the promoter. The downstream gene IκB flag with GFP, which could be a controller in tumor invading，moreover ， easy to observe.

Expriments