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EPF_Lausanne’s team is proud to take part in the iGEM 2013 competition and excited to present their project: Taxi.Coli: smart drug delivery. The team’s vision is to build a biosynthetic drug delivery concept. The key word of this project is “adaptability”. Our goal is to explore a way of using E.coli as a highly modular carrier, opening the gate to several applications and alternatives in disease treatments. Using the principles of synthetic biology, we engineered a gelatinase secreting E.coli able to bind gelatin nanoparticles using a biotin-streptavidin interaction and release their cargo in a corresponding location. The drug delivery system is built in three parts: 1) the nanoparticles binding and 2) the environment sensing that 3) triggers the gelatinase release of the engineered E.coli, liberating the content of the nanoparticle.
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Medal requirements
Bronze medal
- Register the team, have fun in the competition.
- iGEM 2013 Judging form.
- Description of the team's project using the iGEM wiki and the team's parts using the Registry of Standard Biological Parts.
- Present a poster and talk at the iGEM Jamboree.
- Document at least one new standard BioBrick Part and submit it to the Registry + a new application and documentation of a previously existing BioBrick part in the Registry
Silver medal
- Experimentally validate that at least one new BioBrick Part of your own design and construction works as expected.
- Document the characterization of this part and submit this new part to the iGEM Parts Registry
- Implications for the environment, security, safety and ethics and/or ownership and sharing. Describe one or more ways in which these or other broader implications have been taken into consideration in the design and execution of your project.
Gold medal
- Improve the function of an existing BioBrick Part or Device
- Create a new registry page for the improved part, and submit this part to the iGEM Registry
- Outline and detail a new approach to an issue of Human Practice in synthetic biology as it relates to your project, such as safety, security, ethics, or ownership, sharing, and innovation.
