Team:EPF Lausanne

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Taxi.Coli: Smart Drug Delivery iGEM EPFL

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EPF_Lausanne’s team is proud to take part in the iGEM 2013 competition and excited to present their project: Taxi.Coli: smart drug delivery. The team’s vision is to build a biosynthetic drug delivery concept. The key word of this project is “adaptability”. Our goal is to explore a way of using E.coli as a highly modular carrier, opening the gate to several applications and alternatives in disease treatments. Using the principles of synthetic biology, we engineered a gelatinase secreting E.coli able to bind gelatin nanoparticles using a biotin-streptavidin interaction and release their cargo in a corresponding location. The drug delivery system is built in three parts: 1) the nanoparticles binding and 2) the environment sensing that 3) triggers the gelatinase release of the engineered E.coli, liberating the content of the nanoparticle.

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Medal requirements

Bronze medal

  • Register the team, have fun in the competition.
  • iGEM 2013 Judging form.
  • Description of the team's project using the iGEM wiki and the team's parts using the Registry of Standard Biological Parts.
  • Present a poster and talk at the iGEM Jamboree.
  • Document at least one new standard BioBrick Part and submit it to the Registry + a new application and documentation of a previously existing BioBrick part in the Registry

Silver medal

  • Experimentally validate that at least one new BioBrick Part of your own design and construction works as expected.
  • Document the characterization of this part and submit this new part to the iGEM Parts Registry
  • Implications for the environment, security, safety and ethics and/or ownership and sharing. Describe one or more ways in which these or other broader implications have been taken into consideration in the design and execution of your project.

Gold medal

  • Improve the function of an existing BioBrick Part or Device
  • Outline and detail a new approach to an issue of Human Practice in synthetic biology as it relates to your project, such as safety, security, ethics, or ownership, sharing, and innovation.
  • Figure1: Many thank to our sponsor: AC IMMUNE
    Figure1: Many thank to our sponsor: EPFL and our faculty of Life Sciences