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We are proud to participate in iGEM 2013 and are excited to present Taxi.Coli: smart drug delivery.
The basic idea is to create a higly flexible and adaptable smart drug delivery system. The biosynthetic system consists of E.coli as a "Taxi", who express streptavidin on the surface as "Seats" for the "Passangers", which are the biotinylated nanoparticles. Once the Taxi.Coli recognizes a certain medium, it will produce an enzyme that degrades the nanoparticles, thus releasing the incorporated drug.

Achievements:

- We can produce biotinylated nanoparticles
- We can engineer E.coli expressing streptavidin (maybe even on the surface) to bind these nanoparticles
- We can engineer E.coli to sense different levels of pH

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Medal requirements

Bronze medal

We registered the team and had fun in the competition.
We filled in the Judging form.
We described our project using the iGEM wiki and our parts using the Registry of Standard Biological Parts.
We plan to present a poster and talk at the iGEM Jamboree in Lyon.
We designed and submitted the following Biobricks BBa_K1111001, BBa_K1111002, BBa_K111103, BBa_K1111004, BBa_K1111005, BBa_K1111006, BBa_K1111007, BBa_K1111008, BBa_K1111009, BBa_K1111010, BBa_K1111011, BBa_K1111012, BBa_K1111013, BBa_K1111014.

Silver medal

We experimentally validated that the Biobrick BBa_K1111005 works as expected.
We documented all our parts on the iGEM Registry of Standard Biological Parts.
We investigated the safety issues which could be raised by our project. Take a look at our safety page.

Gold medal

We improved the function of the already existing Biobrick BBa_K523013 by extensively characterizing and documenting it. Which will help future teams to use it.
We prepared an amazing synthetic biology kit which will be used at public events and high school visits at EPFL. Take a look at our Outreach page.
We organized a women and engineering's day at our university to promote women in science.