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Team:Arizona State/Future
From 2013.igem.org
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<h3>Dendritic Cell Targeting via aDEC-205 ScFv</h3> | <h3>Dendritic Cell Targeting via aDEC-205 ScFv</h3> | ||
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| - | The ant-DEC205 single chain variable fragment is an antibody fragment that binds to the DEC205 surface protein on dendritic cells. | + | The ant-DEC205 single chain variable fragment is an antibody fragment that binds to the DEC205 surface protein on dendritic cells. We plan to express this scFv on the surface of our vaccine chassis using a surface anchor protein, such as ice nucleation protein, to increase its affinity for dendritic cell targeting and uptake. |
</p> | </p> | ||
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Revision as of 02:16, 28 September 2013
Use of Ubiquitin as a Mechanism for MHC Class I Presentation
Dendritic Cell Targeting via aDEC-205 ScFv
The ant-DEC205 single chain variable fragment is an antibody fragment that binds to the DEC205 surface protein on dendritic cells. We plan to express this scFv on the surface of our vaccine chassis using a surface anchor protein, such as ice nucleation protein, to increase its affinity for dendritic cell targeting and uptake.
