Team:Arizona State/MHC

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Recombinant expression of FluM1 from Influenza & Melan-A from Melanoma provides protein epitope for antigen recognition

The BactoVax vaccine platform has been engineered to act as a general vaccine platform, suitable for vaccination against bacteria, viruses, and tumors. Our current system has been engineered to express both viral antigen FluM1 and cancer surface antigen Melan-A to illustrate the modular nature of the platform itself. Instead of having to engineer a separate vaccine for every single different strain of a particular disease or group of disease separately, BactoVax provides a chassis that can be easily modified simply by addition of the nucleotide sequence for antigen of interest to trigger a specialized immune response.

MHC Pathway presentation Depends Upon Pathogenic characteristics

Expression of Lysteriolysin in E.coli Nissile can confer difference in MHC presentation