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Team:UIUC Illinois
From 2013.igem.org
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<div id="major_image"> | <div id="major_image"> | ||
| - | <img src="https://static.igem.org/mediawiki/2013/ | + | <img src="https://static.igem.org/mediawiki/2013/8/86/Uiuc_new_home_page_pic.jpg" width="720" height="294" alt="Smiling fox" /> |
</div> | </div> | ||
<div id="abstract"> | <div id="abstract"> | ||
| - | Our project, Cardiobiotics, works to prevent cardiovascular disease by reducing the metabolism of dietary | + | Our project, Cardiobiotics, works to prevent cardiovascular disease by reducing the metabolism of dietary L-carnitine within the digestive system. This made possible through the use of three biological parts that fulfill two very important functions: the take-up and the break-down of L-carnitine.<br><br> |
The take-up of L-carnitine into the cell is facilitated by two biobricks: the <a href="http://parts.igem.org/Part:BBa_K1205002">CbcWV Uptake Protein</a> and <a href="http://parts.igem.org/Part:BBa_K1205001">CaiX Carnitine Carrier Protein</a>. This combination of proteins form a membrane-bound carnitine uptake system for bringing greater amounts of L-carnitine into the cell.<br><br> | The take-up of L-carnitine into the cell is facilitated by two biobricks: the <a href="http://parts.igem.org/Part:BBa_K1205002">CbcWV Uptake Protein</a> and <a href="http://parts.igem.org/Part:BBa_K1205001">CaiX Carnitine Carrier Protein</a>. This combination of proteins form a membrane-bound carnitine uptake system for bringing greater amounts of L-carnitine into the cell.<br><br> | ||
| - | The break-down of L-carnitine is carried out by our biobrick <a href="http://parts.igem.org/Part:BBa_K1205000">Carnitine Dehydrogenase</a>. This protein catalyzes the conversion of L-carnitine into 3- | + | The break-down of L-carnitine is carried out by our biobrick <a href="http://parts.igem.org/Part:BBa_K1205000">Carnitine Dehydrogenase</a>. This protein catalyzes the conversion of L-carnitine into 3-dehydrocarnitine, pushing it down an alternative metabolic pathway towaord the creation of the amino acid glycine.<br><br> |
The cells containing the biological parts are then suspended within calcium alginate and inserted into gelatin capsules in order to transport them to the intestinal system. | The cells containing the biological parts are then suspended within calcium alginate and inserted into gelatin capsules in order to transport them to the intestinal system. | ||
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<h3>Human Practices</h3> | <h3>Human Practices</h3> | ||
<ul> | <ul> | ||
| - | + | ||
<li style="margin-bottom:20px;"><a href="https://2013.igem.org/Team:UIUC_Illinois/Human_Practices/Outreach">Outreach</a></li> | <li style="margin-bottom:20px;"><a href="https://2013.igem.org/Team:UIUC_Illinois/Human_Practices/Outreach">Outreach</a></li> | ||
<li style="margin-bottom:20px;"><a href="https://2013.igem.org/Team:UIUC_Illinois/Human_Practices/Ethics">Ethics</a></li> | <li style="margin-bottom:20px;"><a href="https://2013.igem.org/Team:UIUC_Illinois/Human_Practices/Ethics">Ethics</a></li> | ||
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<div id="sponsor_outerbox"> | <div id="sponsor_outerbox"> | ||
<div id="sponsor_innerbox"><img src="https://static.igem.org/mediawiki/2013/6/61/Midsci_logo.jpg" width="267" height="130"></div> | <div id="sponsor_innerbox"><img src="https://static.igem.org/mediawiki/2013/6/61/Midsci_logo.jpg" width="267" height="130"></div> | ||
| - | <div id="sponsor_innerbox"><a href="http:// | + | <div id="sponsor_innerbox"><a href="http://nanobio.illinois.edu/"><img src="https://static.igem.org/mediawiki/2013/c/cf/Nano_bio_logo.png" width="630" height="100"></a></div> |
</div> | </div> | ||
<div id="sponsor_innerbox"><img src="http://res.illumina.com/images/logos/university-illinois-biotech-center.png" width="350" height="75"></div> | <div id="sponsor_innerbox"><img src="http://res.illumina.com/images/logos/university-illinois-biotech-center.png" width="350" height="75"></div> | ||
Latest revision as of 23:40, 19 February 2014
Contact Us
Our project, Cardiobiotics, works to prevent cardiovascular disease by reducing the metabolism of dietary L-carnitine within the digestive system. This made possible through the use of three biological parts that fulfill two very important functions: the take-up and the break-down of L-carnitine.
The take-up of L-carnitine into the cell is facilitated by two biobricks: the CbcWV Uptake Protein and CaiX Carnitine Carrier Protein. This combination of proteins form a membrane-bound carnitine uptake system for bringing greater amounts of L-carnitine into the cell.
The break-down of L-carnitine is carried out by our biobrick Carnitine Dehydrogenase. This protein catalyzes the conversion of L-carnitine into 3-dehydrocarnitine, pushing it down an alternative metabolic pathway towaord the creation of the amino acid glycine.
The cells containing the biological parts are then suspended within calcium alginate and inserted into gelatin capsules in order to transport them to the intestinal system.
The take-up of L-carnitine into the cell is facilitated by two biobricks: the CbcWV Uptake Protein and CaiX Carnitine Carrier Protein. This combination of proteins form a membrane-bound carnitine uptake system for bringing greater amounts of L-carnitine into the cell.
The break-down of L-carnitine is carried out by our biobrick Carnitine Dehydrogenase. This protein catalyzes the conversion of L-carnitine into 3-dehydrocarnitine, pushing it down an alternative metabolic pathway towaord the creation of the amino acid glycine.
The cells containing the biological parts are then suspended within calcium alginate and inserted into gelatin capsules in order to transport them to the intestinal system.
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