Team:UIUC Illinois

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        <a href="https://2013.igem.org/Team:UIUC_Illinois"><img src="https://static.igem.org/mediawiki/2013/0/02/Illinoisigem.png" width="407.36" height="200" alt="UIUC iGEM" class="center" /></a>
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Our project, Cardiobiotics, works to prevent cardiovascular disease by reducing the metabolism of dietary L-carnitine within the digestive system. This made possible through the use of three biological parts that fulfill two very important functions: the take-up and the break-down of L-carnitine.<br><br>
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      <h1>MIT's biggest</h1>
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      <h1>hackathon</h1>
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      <h1>is back.</h1>
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      <p>Open to all students, all schools.</p>
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      <p class="time-location"><span id="time"><i class="icon-time"></i> <a href="http://www.google.com/calendar/event?action=TEMPLATE&text=HackMIT&dates=20131005T000000Z/20131006T120000Z&details=MIT's%20biggest%20hackathon%20is%20back!&location=MIT%20Stata%20Center&trp=true&sprop=HackMIT&sprop=name:hackmit.org" target="_blank">Oct. 4–6, 2013</a></span><span id="location"><i class="icon-map-marker"></i> <a href="https://maps.google.com/maps?q=MIT+Stata+Center&hl=en&sll=42.361893,-71.090566&sspn=0.003464,0.00552&t=h&hnear=Ray+and+Maria+Stata+Center,+Cambridge,+Middlesex,+Massachusetts+02142&z=16">MIT Stata Center</a></span></p>
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The take-up of L-carnitine into the cell is facilitated by two biobricks: the <a href="http://parts.igem.org/Part:BBa_K1205002">CbcWV Uptake Protein</a> and <a href="http://parts.igem.org/Part:BBa_K1205001">CaiX Carnitine Carrier Protein</a>.  This combination of proteins form a membrane-bound carnitine uptake system for bringing greater amounts of L-carnitine into the cell.<br><br>
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    <header class="section-title"><span>Are you ready?</span></header>
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      <p><span class="number">36</span> hours <span class="number">500+</span> hackers <span class="number">$10000+</span> in prizes</p>
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      <p>&middot; breakfast &middot; lunch &middot; dinner &middot; snacks &middot; caffeine &middot; swag &middot;</p>
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      <p>&middot; $200 travel reimbursement &middot;</p>
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The break-down of L-carnitine is carried out by our biobrick <a href="http://parts.igem.org/Part:BBa_K1205000">Carnitine Dehydrogenase</a>. This protein catalyzes the conversion of L-carnitine into 3-dehydrocarnitine, pushing it down an alternative metabolic pathway towaord the creation of the amino acid glycine.<br><br>
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    <header class="section-title"><span>Sponsors</span></header>
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      <!-- Gold Sponsors -->
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The cells containing the biological parts are then suspended within calcium alginate and inserted into gelatin capsules in order to transport them to the intestinal system.
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    <header class="section-title"><span>Frequently Asked Questions</span></header>
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          <h4 id="format" class="question">What's the format of the hackathon?</h4>
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          <p class="answer">Anything goes! Web, desktop, mobile, and hardware projects are all welcome. (All hacks should be computer-related, though.) Projects will be judged based on creativity, technical difficulty, polish, and usefulness.</p>
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  <h3>Home</h3>
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      <li style="margin-bottom:20px;"><a href="https://2013.igem.org/Team:UIUC_Illinois"><u>Home</u></a></li>
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      <li style="margin-bottom:20px;"><a href="https://2012.igem.org/Team:UIUC-Illinois">2012 Team</a></li>
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      <li style="margin-bottom:20px;"><a href="https://2013.igem.org/Team:UIUC_Illinois/Project/Overview">Overview</a></li>
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      <li style="margin-bottom:20px;"><a href="https://2013.igem.org/Team:UIUC_Illinois/Project/Results">Results</a></li>
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      <li style="margin-bottom:20px;"><a href="https://2013.igem.org/Team:_UIUC_Illinois/Notebook">Notebook</a></li>
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  <h3>Achievements</h3>
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      <li style="margin-bottom:20px;"><a href="https://2013.igem.org/Team_UIUC_Illinois/Medal_Requirements">Achievements</a></li>
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  <h3>Safety</h3>
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      <li style="margin-bottom:20px;"><a href="https://igem.org/Team:UIUC_Illinois/Safety/Main">Safety Main Page</a></li>
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          <h4 id="teams" class="question">How big should teams be? Can I do it alone?</h4>
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<div id="bar_box">
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          <p class="answer">Teams should be at most 4 people total. You can do it alone, but it'll be less fun! We'll have a site up to help find teams before the event, and you'll have time at the start to meet others.</p>
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<img src="https://static.igem.org/mediawiki/2013/7/7b/Black_line_450.jpg" width="333"><img src="https://static.igem.org/mediawiki/2013/7/7b/Black_line_450.jpg" width="333"></div>
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<div id="sponsor_text">
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          <h4 id="past-projects" class="question">Are we allowed to build on past projects? Other code?</h4>
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<h3>Thanks to our sponsors!</h3></div>
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          <p class="answer">We strongly discourage building off of existing projects you've worked on. To be fair to others, let us know if you are using some of your old code in your hacks. Using third-party APIs and libraries is definitely okay, as long as they're accessible by everyone else as well.</p>
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<div id="sponsor_outerbox">
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<div id="sponsor_innerbox"><img src="https://static.igem.org/mediawiki/2013/e/e5/Epoch.png" width="150" height="150"></div>
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<div id="sponsor_innerbox"><a href="http://www.igb.illinois.edu/"><img src="https://static.igem.org/mediawiki/2013/2/20/IGB_Logo_New.jpg" width="800" height="132"></a></div>
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<div id="sponsor_innerbox"><a href="http://bioengineering.illinois.edu"><img src="https://static.igem.org/mediawiki/2013/e/e8/Bioedept.jpg" width="299" height="40"></a></div>
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<div id="sponsor_innerbox"><a href="http://ifoundry.illinois.edu/"><img src="https://static.igem.org/mediawiki/2013/1/1d/IFoundry.jpg" width="140" height="42"></a></div>
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          <h4 id="attend" class="question">Who can attend?</h4>
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<div id="sponsor_innerbox"><img src="https://static.igem.org/mediawiki/2013/4/48/Dental.jpg" width="130" height="48"></div>
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          <p class="answer">All undergraduate and graduate students are welcome. You must <a href="http://hackmit.eventbrite.com">register</a> to participate. Don't forget to bring your valid student ID to the hackathon!</p>
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<div id="sponsor_innerbox"><img src="https://static.igem.org/mediawiki/2013/8/81/Fisher.jpg" width="138" height="50"></div>
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          <h4 id="travel" class="question">I'm not too close to MIT. Can I get reimbursed for travel?</h4>
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          <p class="answer">All attendees can claim up to a $200 travel reimbursement. Just make sure to bring a receipt, ticket, and photo ID to the hackathon. <a href="mailto:team@hackmit.org">Email us</a> if you need more.</p>
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Latest revision as of 23:40, 19 February 2014

Contact Us
UIUC iGEM
Smiling fox
Our project, Cardiobiotics, works to prevent cardiovascular disease by reducing the metabolism of dietary L-carnitine within the digestive system. This made possible through the use of three biological parts that fulfill two very important functions: the take-up and the break-down of L-carnitine.

The take-up of L-carnitine into the cell is facilitated by two biobricks: the CbcWV Uptake Protein and CaiX Carnitine Carrier Protein. This combination of proteins form a membrane-bound carnitine uptake system for bringing greater amounts of L-carnitine into the cell.

The break-down of L-carnitine is carried out by our biobrick Carnitine Dehydrogenase. This protein catalyzes the conversion of L-carnitine into 3-dehydrocarnitine, pushing it down an alternative metabolic pathway towaord the creation of the amino acid glycine.

The cells containing the biological parts are then suspended within calcium alginate and inserted into gelatin capsules in order to transport them to the intestinal system.

Retrieved from "http://2013.igem.org/Team:UIUC_Illinois"