Team:Hong Kong HKUST/abstract

From 2013.igem.org

(Difference between revisions)
 
(10 intermediate revisions not shown)
Line 1: Line 1:
<html>
<html>
<head>
<head>
-
<script src="http://ajax.googleapis.com/ajax/libs/jquery/1.10.1/jquery.min.js">
+
<script src="http://ajax.googleapis.com/ajax/libs/jquery/1.10.2/jquery.min.js">
</script>
</script>
Line 29: Line 29:
});
});
</script>
</script>
-
 
-
 
<style type="text/css">
<style type="text/css">
-
div.menu
+
body{background-color:#494042;width:100%;margin-bottom:20px;min-width:600px;max-width:2000px;height:100%;}
-
{
+
#menubar
-
width:100%;
+
{background-color:#EEECEC;opacity:0.8;top:-4px;width:360px;height:23px;position:absolute;top:-20px;}
-
}
+
#menubar ul li a
-
 
+
{ color:#8D1919;}
 +
#menubar.right-menu
 +
{background-color:#EEECEC;opacity:0.8;top:-4px;width:240px;height:23px;position:absolute;top:-20px;}
 +
.right-menu li a
 +
{color:#8D1919;background-color:#EEECEC;}
 +
#p-logo
 +
{visibility:hidden;}
 +
.firstHeading
 +
{visibility:hidden;}
 +
#globalWrapper
 +
{position: relative;font-size:127%;width:100%;margin:0;padding:0;padding-bottom:10px;background-color:#494042;}
 +
#content
 +
{width: 1000px;border:none;background-color:#494042;padding:0px;margin-top:0px;line-height: 1.5em;color: black;}
 +
#top-section
 +
{height:2px;border:none;background-color:#494042;}
 +
#catlinks
 +
{border-color:#494042;background-color:#494042;}
 +
#footer-box
 +
{display:none}
 +
#kepala
 +
{position:absolute;top:15px;background-color:#F0A5BE;height:121px;width:100%;}
 +
#copyright
 +
{position:absolute;left:325px;top:630px;}
.menu ul,li
.menu ul,li
{
{
Line 44: Line 64:
width:100%;
width:100%;
}
}
-
 
-
 
-
 
ul.first>li
ul.first>li
{
{
float:left;
float:left;
-
width:16.5%;
+
width:16.66%;
}
}
ul.first>li>a:link,ul.first>li>a:visited
ul.first>li>a:link,ul.first>li>a:visited
Line 66: Line 83:
ul.first>li>a:hover,ul.first>li>a:active
ul.first>li>a:hover,ul.first>li>a:active
{
{
-
background-color:#7A991A;
+
background-color:#e32e51;
}
}
Line 89: Line 106:
ul.first>li>ul>li>a:hover,ul.first>li>ul>li>a:active
ul.first>li>ul>li>a:hover,ul.first>li>ul>li>a:active
{
{
-
background-color:#B26B00;
+
background-color:#f87790;
}
}
.menu
.menu
{
{
position:absolute;
position:absolute;
-
left:-8px;
+
left:0px;
-
top:140px;
+
top:141px;
 +
width:100%;
}
}
-
#banner
+
ul, ol {
-
{
+
line-height: 1.6;
-
position:absolute;
+
font-size: 14px;
-
left:-8px;
+
-
top:15px;
+
}
}
-
 
+
#slide{width:96%;height:auto;background-color:#F4DFC0;margin-top:80px;border:2px solid;
-
 
+
border-radius:15px;padding-right:10px;margin-left:15px;}
-
#copyright
+
.center
{
{
-
position:absolute;
+
margin:auto;
-
right:320px;
+
width:70%;
-
top:700px;
+
background-color:#b0e0e6;
}
}
-
#globalWrapper
+
#interview,#presentation,#article, #interview1, #presentation1,#article1
-
{
+
{margin-top:20px;width:30%;margin-right:20px;float:left;height:250px; border:2px solid;
-
background-color:#b9b2a0;
+
border-radius:15px;font-family:"Trebuchet MS", Helvetica, sans-serif;}
-
height:800px;
+
#interview
-
}
+
{margin-left:25px;background:#e32e51;}
-
#content
+
#interview1
-
{
+
{margin-left:25px;background:#35bb91;}
-
background-color:#b9b2a0;
+
#presentation,#article1
-
border-color:#b9b2a0;
+
{background:#35bb91;}
 +
#article,#presentation1
 +
{background:#e32e51;}
 +
#art-desc,#pre-desc,#int-desc{width:50%;float:right;margin-right:8px;}
 +
#art-img,#pre-img,#int-img{width:45%;float:left;margin-left:5px;}
 +
#art-desc-text,#pre-desc-text,#int-desc-text{text-align:justify;float:right;}
 +
h3,h1,#yo{margin-left:10px;font-family:"Trebuchet MS", Helvetica, sans-serif;}
 +
h1{font-size:35px;}
-
}
+
#iGEM_Logo{
-
#menubar
+
width:100px;
-
{  
+
height:80px;
-
background-color:#EEECEC;
+
-
opacity:0.8;
+
-
top:-4px;
+
-
width:360px;
+
-
height:23px;
+
position:absolute;
position:absolute;
-
top:-20px;
+
right:10px;
 +
top:60px;
 +
z-index:+15;
}
}
-
#menubar ul li a
+
#hkust_Logo{
-
{  
+
width:60px;
-
color:#8D1919;
+
height:80px;
-
}
+
-
#menubar.right-menu
+
-
{
+
-
background-color:#EEECEC;
+
-
opacity:0.8;
+
-
top:-4px;
+
-
width:240px;
+
-
height:23px;
+
position:absolute;
position:absolute;
-
top:-20px;
+
right:110px;
 +
top:60px;
 +
z-index:+15;
}
}
-
.right-menu li a
 
-
{
 
-
color:#8D1919; 
 
-
background-color:#EEECEC;
 
-
}
 
-
 
-
#p-logo
 
-
{
 
-
height:0px;
 
-
visibility:hidden;
 
-
}
 
-
#top-section
 
-
{
 
-
height:0px;
 
-
}
 
-
#footer-box
 
-
{
 
-
height:0px;
 
-
display:none;
 
-
visbility:hidden;
 
-
}
 
-
#catlinks
 
-
{
 
-
border-color:#b9b2a0;
 
-
background-color:#b9b2a0;
 
-
}
 
-
.firstHeading
 
-
{
 
-
visibility:hidden
 
-
}
 
-
 
</style>
</style>
-
 
</head>
</head>
 +
<body>
 +
 
 +
          <a href="https://2013.igem.org/Main_Page"><img id="iGEM_Logo" src="https://static.igem.org/mediawiki/2013/4/46/Igem_qgem_logo.png"></a>
 +
         
 +
<a href="http://www.ust.hk/eng/index.htm"><img id="hkust_Logo" src="https://static.igem.org/mediawiki/2013/5/55/Hkust_logo.gif"></a>
-
<body>
+
<a href=https://2013.igem.org/Team:Hong_Kong_HKUST><center><div id="kepala"><img src="https://static.igem.org/mediawiki/igem.org/c/c7/BANNER1_%281%29.png" style="height:121px;width:100%;"></div></center></a>
-
<h3><center><div style="height:121px;width:965px;"><img src="https://static.igem.org/mediawiki/2013/5/5a/Banner_gear.png" id="banner" style="height:121px;width:965px;align:middle;"></div></center></h3>
+
-
<div id="copyright">© Copyright HKUST iGEM Team 2013, All Rights Reserved<br><br><br></div>
 
<div class="menu">
<div class="menu">
-
 
<ul class="first">
<ul class="first">
Line 198: Line 182:
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/advisors">Advisors</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/advisors">Advisors</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/instructors">Instructors</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/instructors">Instructors</a></li>
 +
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/attribution">Attribution</a></li>
 +
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/acknowledge">Acknowledgement</a></li>
</ul>
</ul>
</li>
</li>
-
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/project">Project</a>
+
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/Project">Project</a>
<ul>
<ul>
-
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/abstract">Abstract(Details)</a></li>
+
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/abstract">Abstract</a></li>
-
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/modelling">Modelling</a></li>
+
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/modules">Modules Description</a></li>
 +
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/data">Data Page</a></li>
 +
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/Parts">Parts</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/characterization">Characterization</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/characterization">Characterization</a></li>
-
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/parts">Parts</a></li>
+
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/results">Result</a></li>
-
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/datapage">Data Page</a></li>
+
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/future">Future Work</a></li>
-
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/results">Results</a></li>
+
</ul>
</ul>
</li>
</li>
-
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/wetlab">Wetlab</a>
+
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/Wetlab">Wetlab</a>
<ul>
<ul>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/notebook">Notebook</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/notebook">Notebook</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/protocols">Protocols</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/protocols">Protocols</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/safety">Safety</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/safety">Safety</a></li>
 +
</ul>
</ul>
</li>
</li>
Line 222: Line 210:
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/achievement">Achievement</a>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/achievement">Achievement</a>
<ul>
<ul>
-
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/medalreqeirements">Medal Requirements</a></li>
+
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/medals">Medal Requirements</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/prizes">Prizes</a></li>
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/prizes">Prizes</a></li>
</ul>
</ul>
</li>
</li>
-
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/humanpractice">Human Practice</a></li>
+
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/hp">Human Practice</a>
 +
<ul>
 +
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/hp/cp">Country Profile</a></li>
 +
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/hp/blog">Blog</a></li>
 +
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/hp/interview">Interviews</a></li>
 +
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/hp/article/genet">Article</a></li>
 +
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/hp/video">Videos</a></li>
 +
<li><a href="https://2013.igem.org/Team:Hong_Kong_HKUST/hp/presentation">Presentations</a></li>
 +
</ul>
 +
</li>
</ul>
</ul>
-
</div>
 
-
 
 +
</div>
 +
<br><br><br>
 +
<div id="slide"><h1>Abstract</h1>
 +
<p id="yo">While a low-fat diet and regular exercise are popular approaches to combat obesity, one easy alternative is simply to increase energy metabolism. Employing a synthetic biology approach, we are working to create an artificial futile cycle in mammalian liver cells by introducing glyoxylate enzymes native to bacteria. Past research has shown that mice expressing enzymes facilitating an active glyoxylate shunt are resistant to diet-induced obesity. Our team plans to introduce an inducible system that allows us to couple the sensing of circulating fatty acid concentrations with a circuit of glyoxylate shunt. Our inducible system is intended to prevent the risk of fatty acid deficiency, while facilitating greater fatty acid uptake at higher fatty acid circulating concentrations. Such a system should increase the feasibility of a glyoxylate cycle engineered to function <i>in vivo</i>. </p>
 +
<br><br>
 +
</div>
-
</body>
 
</html>
</html>

Latest revision as of 23:00, 27 September 2013




Abstract

While a low-fat diet and regular exercise are popular approaches to combat obesity, one easy alternative is simply to increase energy metabolism. Employing a synthetic biology approach, we are working to create an artificial futile cycle in mammalian liver cells by introducing glyoxylate enzymes native to bacteria. Past research has shown that mice expressing enzymes facilitating an active glyoxylate shunt are resistant to diet-induced obesity. Our team plans to introduce an inducible system that allows us to couple the sensing of circulating fatty acid concentrations with a circuit of glyoxylate shunt. Our inducible system is intended to prevent the risk of fatty acid deficiency, while facilitating greater fatty acid uptake at higher fatty acid circulating concentrations. Such a system should increase the feasibility of a glyoxylate cycle engineered to function in vivo.