Team:Paris Bettencourt

From 2013.igem.org

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      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Overview" title="Project Overview">
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<div class="subpanel1">
-
  </div>
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  <div style="position:relative;bottom:0px">
-
</div>
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    <div class="cont"><p style="font-size:32px;line-height:34px;">FIGHT TUBERCULOSIS WITH MODERN WEAPONS </p></div>
-
<div style="clear: both;"></div>
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<script src="http://ajax.googleapis.com/ajax/libs/jquery/1.8.3/jquery.min.js"></script>
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      <p style="font-size:26px;">
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<div id="page">
+
Tuberculosis (TB) is an infectious disease caused by <i>Mycobacterium tuberculosis</i> (Mtb) that affects nearly two billion people around the world. On this website we present four new ways to use the power of synthetic biology in the fight against TB: from gene detection, to drug targeting, to infiltrating macrophages, to sabotaging the synthesis of proteins. Hover over these panels to see the project overview.
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      </p>
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  <div class="subpanel1" style="margin-right:12px;margin-bottom:12px;">
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    </div>
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    <div id="psdesc" class="spdesc">
-
      <div class="cont">
+
      <div class="cont">
-
Tuberculosis is an infectious disease caused by <i>Mycobacterium tuberculosis</i>, that affects millions of people over the world. Using <i>Escherichia coli</i> as a model organism we are developing different approaches that could contribute to the eradication of tuberculosis.
+
<p style="font-size:26px;">A biosensor that detects the presence of sequence specific antibiotic resistance genes.</p>
-
      </div>
+
      </div>
 +
    </div>
 +
    <div id="dsdesc" class="spdesc">
 +
      <div class="cont">
 +
<p style="font-size:26px;">A safe and specific high-throughput drug screening method that targets essential mycobacterial metabolic proteins.</p>
 +
      </div>    
 +
    </div>
 +
    <div id="thdesc" class="spdesc">
 +
      <div class="cont">
 +
<p style="font-size:26px;">A phage system with low fitness cost producing sRNA, which inhibits the synthesis of antibiotic resistance proteins.</p>
 +
      </div>
 +
    </div>
 +
    <div id="tcdesc" class="spdesc">
 +
      <div class="cont">
 +
<p style="font-size:26px;">Infiltrate macrophages with an <i>E.coli</i> producing TDMH, an enzyme that will lyse the Mycobacteria cell wall.</p>
 +
      </div>
 +
    </div>
 +
  </div>
 +
</div>
 +
      </a>
 +
      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Detect" title="Detect">
 +
<div id="pspanel" class="subpanel2"  onmouseover="chgtrans(this)">
 +
  <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/a/a8/PB_DetectNarrow.jpg" width="125px" height="500px"/>
 +
  <div class="titlebox">
 +
    <center><img src="https://static.igem.org/mediawiki/2013/0/0b/PB_detecticon.gif" style="height:60px;margin-bottom:20px;"/></center>
 +
    <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
    Detect
 +
  </div>
 +
</div>
 +
      </a>
 +
      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Target" title="Target">
 +
<div id="dspanel" class="subpanel2">
 +
  <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/e/e2/PB_TargetNarrow.jpg" width="125px" height="500px"/>
 +
  <div class="titlebox">
 +
    <center><img src="https://static.igem.org/mediawiki/2013/1/11/PB_TargetIcon.gif" style="height:60px;margin-bottom:20px;"/></center>
 +
    <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
    Target
 +
  </div>
 +
</div>
 +
      </a>
 +
      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Infiltrate" title="Infiltrate">
 +
<div id="tcpanel" class="subpanel2">
 +
  <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/2/21/PB_InfiltrateNarrow.jpg" width="125px" height="500px"/>
 +
  <div class="titlebox">
 +
    <center><img src="https://static.igem.org/mediawiki/2013/6/6c/PB_infiltrate.gif" style="height:60px;margin-bottom:20px;"/></center>
 +
    <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
    Infiltrate
 +
  </div>
 +
</div>
 +
      </a>
 +
      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Sabotage" title="Sabotage">
 +
<div id="thpanel" class="subpanel2">     
 +
  <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/4/42/PB_SabotageNarrow.jpg" width="125px" height="500px"/>
 +
  <div class="titlebox">
 +
    <center><img src="https://static.igem.org/mediawiki/2013/8/81/PB_sabotageicone.gif" style="height:60px;margin-bottom:20px;"/></center>
 +
    <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
    Sabotage
 +
  </div>
 +
</div>
 +
      </a>
 +
      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Results" title="Results">
 +
<div class="subpanel3" >
 +
  <img width="70px" style="margin-left:80px;margin-right:15px;position:relative;bottom:1px" src="https://static.igem.org/mediawiki/2013/d/d5/PB_handresults.gif"/>Jump to Results
 +
</div>
 +
      </a>
     </div>
     </div>
-
     <div id="psdesc" class="spdesc">
+
     <div style="clear: both;"></div>
-
       <div class="cont">
+
    <div class="panel" style="background:white;">
-
A phage system that detects the presence of sequence specific antibiotic resistance genes.
+
       <div class="subpanel4">
 +
<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/TB_Facts" title="TB Facts">
 +
  <div class="subpanel5">
 +
    <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/f/f9/PB_TBfacts2.png" width="354px" height="156px"/>
 +
    <div style="position:relative;bottom:148px">
 +
              <center><img src="https://static.igem.org/mediawiki/2013/6/69/PB_logoTBfacts.png" style="height:50px;margin-top:10px;margin-bottom:20px;"/></center>
 +
              <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
              TB Facts
 +
    </div>
 +
  </div>
 +
</a>     
 +
<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/TB_France" title="TB in France">
 +
  <div class="subpanel5">
 +
    <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/3/39/PB_TBinFrance.png" width="354px" height="156px"/>     
 +
    <div style="position:relative;bottom:158px">       
 +
              <center><img src="https://static.igem.org/mediawiki/2013/c/cf/PB_logofrance.png" style="height:50px;margin-top:10px;margin-bottom:20px;"/></center>
 +
              <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
              TB in France
 +
            </div>
 +
  </div>
 +
</a>
 +
<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/TB_Gallery" title="TB Gallery">
 +
  <div class="subpanel5" style="margin-bottom:0;height:158px;">
 +
    <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/2/2f/PB_TBgallery%281%29.png" width="354px" height="156px"/>
 +
    <div style="position:relative;bottom:158px">
 +
              <center><img src="https://static.igem.org/mediawiki/2013/d/de/PB_logoTBgallery.png" style="height:60px;margin-top:10px;margin-bottom:10px;"/></center>
 +
              <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
              TB Gallery
 +
    </div>
 +
  </div>
 +
</a>
       </div>
       </div>
-
    </div>
+
      <div class="subpanel4">
-
    <div id="dsdesc" class="spdesc">
+
<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/Gender_Study" title="Gender Study">
-
       <div class="cont">
+
  <div class="subpanel7">
-
A safe and specific drug screening method that targets essential mycobacterial metabolic proteins.
+
    <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/8/8c/Gender.png" width="354px" height="283px"/>
-
      </div>  
+
    <div style="position:relative;bottom:258px">
-
    </div>
+
              <center><img src="https://static.igem.org/mediawiki/2013/d/da/PB_logogender.png" style="height:60px;margin-top:10px;margin-bottom:10px;"/></center>
-
    <div id="thdesc" class="spdesc">
+
              <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
-
      <div class="cont">
+
              Gender Study
-
A phage system with low fitness cost, producing sRNA which inhibit the synthesis of antibiotic resistance proteins.
+
    </div>
 +
  </div>
 +
</a>
 +
<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/Technology_Transfer" title="Technology Transfer">
 +
  <div class="subpanel9" style="font-size:26px;">
 +
    <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/3/3c/TB_knowledge.png" width="354px" height="283px"/>
 +
    <div style="position:relative;bottom:258px">       
 +
              <center><img src="https://static.igem.org/mediawiki/2013/6/6d/PB_logotransferttechno.png" style="height:60px;margin-top:10px;margin-bottom:10px;"/></center>
 +
              <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
              Technology Transfer
 +
    </div>
 +
  </div>
 +
</a>
 +
      </div>
 +
       <div class="subpanel4" style="margin-right:0px">
 +
<div style="margin-right:0;width:356px">
 +
  <a href="https://2013.igem.org/Team:Paris_Bettencourt/Collaboration" title="Collaboration">
 +
    <div class="subpanel6">
 +
      <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/e/e4/TB_collboration2.png" width="354px" height="283px"/>
 +
      <div style="position:relative;bottom:258px">
 +
<center><img src="https://static.igem.org/mediawiki/2013/7/75/PB_lofocollaboration.png" style="height:50px;margin-top:15px;margin-bottom:15px;"/></center>
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<div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
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Collaboration
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      </div>
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  </a>
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  <a href="https://2013.igem.org/Team:Paris_Bettencourt/SensiGEM" title="SensiGEM">
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      <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/d/d5/TB_senigem.png" width="354px" height="283px"/>
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<center><img src="https://static.igem.org/mediawiki/2013/3/3c/PB_logosenigem.png" style="height:60px;margin-top:10px;margin-bottom:10px;"/></center>
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SensiGEM
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An <i>E. coli</i> which invades macrophages and kills mycobacteria.
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<a href="https://2013.igem.org/Team:Paris_Bettencourt/Team" title="Team">
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<a href="https://2013.igem.org/Team:Paris_Bettencourt/Parts" title="Submitted Parts">
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  <center><img src="https://static.igem.org/mediawiki/2013/0/02/PB_Partslogo.png" height="64px"/></center>
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      TARGET
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      INFILTRATE
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Latest revision as of 14:06, 6 November 2013

FIGHT TUBERCULOSIS WITH MODERN WEAPONS

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) that affects nearly two billion people around the world. On this website we present four new ways to use the power of synthetic biology in the fight against TB: from gene detection, to drug targeting, to infiltrating macrophages, to sabotaging the synthesis of proteins. Hover over these panels to see the project overview.

A biosensor that detects the presence of sequence specific antibiotic resistance genes.

A safe and specific high-throughput drug screening method that targets essential mycobacterial metabolic proteins.

A phage system with low fitness cost producing sRNA, which inhibits the synthesis of antibiotic resistance proteins.

Infiltrate macrophages with an E.coli producing TDMH, an enzyme that will lyse the Mycobacteria cell wall.
Detect
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Jump to Results
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Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
+33 1 44 41 25 22/25
team2013@igem-paris.org
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