Team:Paris Bettencourt

From 2013.igem.org

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   </div>
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   <img src="https://static.igem.org/mediawiki/2013/3/3a/PB_logoParis.gif" width="122px" style="position:relative;bottom:580px;left:30px;"/>
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    <div class="panel">
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<div id="page">
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      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Overview" title="Project Overview">
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<div id="panel10">
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<div class="subpanel1">
-
We are testing new weapons for the global war against Mycobacterium tuberculosis (MTb), a pathogen that infects nearly 2 billion people. Our 4 synergistic projects aim to help in the prevention, diagnosis, and treatment of tuberculosis. 1) We are reproducing an essential MTb metabolic pathway in E. coli, where it can be easily and safely targeted in a drug screen. 2) We are building a phage-based biosensor to allow the rapid diagnosis specifically drug-resistant MTb strains. 3) We are constructing a mycobacteriophage to detect and counterselect drug-resistant Mtb in the environment. 4) We are programming E. coli to follow MTb into human macrophages and saturate it with bacteriolytic enzymes. We want to vanquish tuberculosis and build a TB-free world.
+
  <div style="position:relative;bottom:0px">
-
</div>
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    <div class="cont"><p style="font-size:32px;line-height:34px;">FIGHT TUBERCULOSIS WITH MODERN WEAPONS </p></div>
-
<div class="panel">
+
    <div class="cont">
-
  <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Overview" title="Project Overview">
+
      <p style="font-size:26px;">
-
  <div class="subpanel1">
+
Tuberculosis (TB) is an infectious disease caused by <i>Mycobacterium tuberculosis</i> (Mtb) that affects nearly two billion people around the world. On this website we present four new ways to use the power of synthetic biology in the fight against TB: from gene detection, to drug targeting, to infiltrating macrophages, to sabotaging the synthesis of proteins. Hover over these panels to see the project overview.
-
    <!--<img style="opacity:0.8" src="https://static.igem.org/mediawiki/2013/7/78/PB_ProjectLarge1.jpg" width="535px" height="428px" />--!>
+
      </p>
-
    <div style="position:relative;bottom:0px">
+
    </div>
-
    <div class="cont"><p style="font-size:32px;line-height:34px;">FIGHT TUBERCULOSIS WITH MODERN WEAPONS </p></div>
+
    <div id="psdesc" class="spdesc">
-
    <div class="cont">
+
      <div class="cont">
-
      <p style="font-size:28px;">
+
<p style="font-size:26px;">A biosensor that detects the presence of sequence specific antibiotic resistance genes.</p>
-
       Tuberculosis (TB) is an infectious disease caused by <i>Mycobacterium tuberculosis</i> (Mtb) that affects nearly two billion people around the world. On this website we present four new ways to use the power of synthetic biology in the fight against TB.
+
      </div>
-
       </p>
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    </div>
 +
    <div id="dsdesc" class="spdesc">
 +
      <div class="cont">
 +
<p style="font-size:26px;">A safe and specific high-throughput drug screening method that targets essential mycobacterial metabolic proteins.</p>
 +
      </div>  
 +
    </div>
 +
    <div id="thdesc" class="spdesc">
 +
      <div class="cont">
 +
<p style="font-size:26px;">A phage system with low fitness cost producing sRNA, which inhibits the synthesis of antibiotic resistance proteins.</p>
 +
      </div>
 +
    </div>
 +
    <div id="tcdesc" class="spdesc">
 +
      <div class="cont">
 +
<p style="font-size:26px;">Infiltrate macrophages with an <i>E.coli</i> producing TDMH, an enzyme that will lyse the Mycobacteria cell wall.</p>
 +
      </div>
 +
    </div>
 +
  </div>
 +
</div>
 +
      </a>
 +
      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Detect" title="Detect">
 +
<div id="pspanel" class="subpanel2"  onmouseover="chgtrans(this)">
 +
  <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/a/a8/PB_DetectNarrow.jpg" width="125px" height="500px"/>
 +
  <div class="titlebox">
 +
    <center><img src="https://static.igem.org/mediawiki/2013/0/0b/PB_detecticon.gif" style="height:60px;margin-bottom:20px;"/></center>
 +
    <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
    Detect
 +
  </div>
 +
</div>
 +
      </a>
 +
      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Target" title="Target">
 +
<div id="dspanel" class="subpanel2">
 +
  <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/e/e2/PB_TargetNarrow.jpg" width="125px" height="500px"/>
 +
  <div class="titlebox">
 +
    <center><img src="https://static.igem.org/mediawiki/2013/1/11/PB_TargetIcon.gif" style="height:60px;margin-bottom:20px;"/></center>
 +
    <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
    Target
 +
  </div>
 +
</div>
 +
      </a>
 +
      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Infiltrate" title="Infiltrate">
 +
<div id="tcpanel" class="subpanel2">
 +
  <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/2/21/PB_InfiltrateNarrow.jpg" width="125px" height="500px"/>
 +
  <div class="titlebox">
 +
    <center><img src="https://static.igem.org/mediawiki/2013/6/6c/PB_infiltrate.gif" style="height:60px;margin-bottom:20px;"/></center>
 +
    <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
    Infiltrate
 +
  </div>
 +
</div>
 +
      </a>
 +
      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Sabotage" title="Sabotage">
 +
<div id="thpanel" class="subpanel2">    
 +
  <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/4/42/PB_SabotageNarrow.jpg" width="125px" height="500px"/>
 +
  <div class="titlebox">
 +
    <center><img src="https://static.igem.org/mediawiki/2013/8/81/PB_sabotageicone.gif" style="height:60px;margin-bottom:20px;"/></center>
 +
    <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
    Sabotage
 +
  </div>
 +
</div>
 +
       </a>
 +
      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Results" title="Results">
 +
<div class="subpanel3" >
 +
  <img width="70px" style="margin-left:80px;margin-right:15px;position:relative;bottom:1px" src="https://static.igem.org/mediawiki/2013/d/d5/PB_handresults.gif"/>Jump to Results
 +
</div>
 +
       </a>
     </div>
     </div>
-
     <div id="psdesc" class="spdesc">
+
     <div style="clear: both;"></div>
-
       <div class="cont">
+
    <div class="panel" style="background:white;">
-
<p style="font-size:28px;">A biosensor that detects the presence of sequence specific antibiotic resistance genes.</p>
+
       <div class="subpanel4">
 +
<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/TB_Facts" title="TB Facts">
 +
  <div class="subpanel5">
 +
    <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/f/f9/PB_TBfacts2.png" width="354px" height="156px"/>
 +
    <div style="position:relative;bottom:148px">
 +
              <center><img src="https://static.igem.org/mediawiki/2013/6/69/PB_logoTBfacts.png" style="height:50px;margin-top:10px;margin-bottom:20px;"/></center>
 +
              <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
 +
              TB Facts
 +
    </div>
 +
  </div>
 +
</a>     
 +
<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/TB_France" title="TB in France">
 +
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-
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<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/Gender_Study" title="Gender Study">
-
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  <div class="subpanel7">
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<p style="font-size:28px;">A safe and specific high-throughput drug screening method that targets essential mycobacterial metabolic proteins.</p>
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<p style="font-size:28px;">A phage system with low fitness cost producing sRNA, which inhibit the synthesis of antibiotic resistance proteins.</p>
+
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<p style="font-size:28px;">Infiltrate macrophages with an <i>E.coli</i> producing TDMH, an enzyme that will lyse the Mycobacteria cell wall.</p>
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Latest revision as of 14:06, 6 November 2013

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