Team:Paris Bettencourt

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About one third of the world’s population has at one point in their life been infected with tuberculosis (TB) causing bacteria <em>Mycobacterium tuberculosis</em>. Luckily, nine out of ten infections are asymptomatic and latent but one out of ten progresses to a lethal active disease killing millions of people worldwide. In most cases tuberculosis attacks lungs, invading alveolar macrophages where it lives and replicates. Due to its habitat and the unusual structure and chemical composition of the cell wall many antibiotics are ineffective, making TB treatment difficult and hard to tackle. Additionally, in recent years multiple drug-resistant tuberculosis became an ever increasing problem too.
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Using Escherichia coli as a model organism we are developing and testing approaches that could lead to eradication of this infectious disease. A drug screen aimed for a specific mycobacterial metabolic pathway, a phage sensor for detection of a specific antibiotic resistance, a TB ception E. coli which could invade microphages and kill mycobacteria, and finally a Trojan horse sRNA which could silence the production of antibiotic resistance proteins thus making antibiotic treatment more effective.
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      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Overview" title="Project Overview">
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<div class="subpanel1">
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  <div style="position:relative;bottom:0px">
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    <div class="cont"><p style="font-size:32px;line-height:34px;">FIGHT TUBERCULOSIS WITH MODERN WEAPONS </p></div>
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    <div class="cont">
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      <p style="font-size:26px;">
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Tuberculosis (TB) is an infectious disease caused by <i>Mycobacterium tuberculosis</i> (Mtb) that affects nearly two billion people around the world. On this website we present four new ways to use the power of synthetic biology in the fight against TB: from gene detection, to drug targeting, to infiltrating macrophages, to sabotaging the synthesis of proteins. Hover over these panels to see the project overview.
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<p style="font-size:26px;">A biosensor that detects the presence of sequence specific antibiotic resistance genes.</p>
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      <div class="cont">
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<p style="font-size:26px;">A safe and specific high-throughput drug screening method that targets essential mycobacterial metabolic proteins.</p>
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      </div>  
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    </div>
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    <div id="thdesc" class="spdesc">
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      <div class="cont">
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<p style="font-size:26px;">A phage system with low fitness cost producing sRNA, which inhibits the synthesis of antibiotic resistance proteins.</p>
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      </div>
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    </div>
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    <div id="tcdesc" class="spdesc">
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      <div class="cont">
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<p style="font-size:26px;">Infiltrate macrophages with an <i>E.coli</i> producing TDMH, an enzyme that will lyse the Mycobacteria cell wall.</p>
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      </div>
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</div>
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      </a>
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      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Detect" title="Detect">
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    Detect
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</div>
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      </a>
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      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Target" title="Target">
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    Target
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      </a>
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      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Infiltrate" title="Infiltrate">
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    <center><img src="https://static.igem.org/mediawiki/2013/6/6c/PB_infiltrate.gif" style="height:60px;margin-bottom:20px;"/></center>
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    Infiltrate
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      </a>
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      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Project/Sabotage" title="Sabotage">
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    <center><img src="https://static.igem.org/mediawiki/2013/8/81/PB_sabotageicone.gif" style="height:60px;margin-bottom:20px;"/></center>
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    Sabotage
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      </a>
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      <a href="https://2013.igem.org/Team:Paris_Bettencourt/Results" title="Results">
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<div class="subpanel3" >
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  <img width="70px" style="margin-left:80px;margin-right:15px;position:relative;bottom:1px" src="https://static.igem.org/mediawiki/2013/d/d5/PB_handresults.gif"/>Jump to Results
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<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/TB_Facts" title="TB Facts">
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              <center><img src="https://static.igem.org/mediawiki/2013/6/69/PB_logoTBfacts.png" style="height:50px;margin-top:10px;margin-bottom:20px;"/></center>
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              <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
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              TB Facts
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    </div>
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  </div>
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</a>     
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<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/TB_France" title="TB in France">
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  <div class="subpanel5">
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    <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/3/39/PB_TBinFrance.png" width="354px" height="156px"/>     
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    <div style="position:relative;bottom:158px">       
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              <center><img src="https://static.igem.org/mediawiki/2013/c/cf/PB_logofrance.png" style="height:50px;margin-top:10px;margin-bottom:20px;"/></center>
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              <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
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              TB in France
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            </div>
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</a>
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              <center><img src="https://static.igem.org/mediawiki/2013/d/de/PB_logoTBgallery.png" style="height:60px;margin-top:10px;margin-bottom:10px;"/></center>
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              TB Gallery
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</a>
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<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/Gender_Study" title="Gender Study">
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              <center><img src="https://static.igem.org/mediawiki/2013/d/da/PB_logogender.png" style="height:60px;margin-top:10px;margin-bottom:10px;"/></center>
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              <div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
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              Gender Study
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</a>
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<a href="https://2013.igem.org/Team:Paris_Bettencourt/Human_Practice/Technology_Transfer" title="Technology Transfer">
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  <div class="subpanel9" style="font-size:26px;">
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    <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/3/3c/TB_knowledge.png" width="354px" height="283px"/>
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    <div style="position:relative;bottom:258px">       
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              <center><img src="https://static.igem.org/mediawiki/2013/6/6d/PB_logotransferttechno.png" style="height:60px;margin-top:10px;margin-bottom:10px;"/></center>
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              Technology Transfer
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</a>
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<div style="margin-right:0;width:356px">
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  <a href="https://2013.igem.org/Team:Paris_Bettencourt/Collaboration" title="Collaboration">
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      <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/e/e4/TB_collboration2.png" width="354px" height="283px"/>
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<center><img src="https://static.igem.org/mediawiki/2013/7/75/PB_lofocollaboration.png" style="height:50px;margin-top:15px;margin-bottom:15px;"/></center>
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<div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
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Collaboration
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      </div>
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  </a>
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  <a href="https://2013.igem.org/Team:Paris_Bettencourt/SensiGEM" title="SensiGEM">
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      <img class="narrowimg" src="https://static.igem.org/mediawiki/2013/d/d5/TB_senigem.png" width="354px" height="283px"/>
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      <div style="position:relative;bottom:258px">
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<center><img src="https://static.igem.org/mediawiki/2013/3/3c/PB_logosenigem.png" style="height:60px;margin-top:10px;margin-bottom:10px;"/></center>
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<div style="width:60%;margin-left:20%;margin-bottom:20px;"><hr></div>
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SensiGEM
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  </a>
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<a href="https://2013.igem.org/Team:Paris_Bettencourt/Team" title="Team">
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  <center><img src="https://static.igem.org/mediawiki/2013/1/1c/PB_Teamlogo.png" height="64px"/></center>
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</a>
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      <div class="subpanel8">
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<a href="https://2013.igem.org/Team:Paris_Bettencourt/Notes" title="Notebook">
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  <center><img src="https://static.igem.org/mediawiki/2013/2/27/PB_Notebooklogo.png" height="64px"/></center> 
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</a>
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<a href="https://2013.igem.org/Team:Paris_Bettencourt/Parts" title="Submitted Parts">
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  <center><img src="https://static.igem.org/mediawiki/2013/0/02/PB_Partslogo.png" height="64px"/></center>
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</a>
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      </div>
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      <div class="subpanel8" style="margin-right:0">
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<a href="https://2013.igem.org/Team:Paris_Bettencourt/Medal_Fulfillment" title="Medal Fulfillment">
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  <center><img src="https://static.igem.org/mediawiki/2013/2/2a/PB_medallogo.png" height="64px"/></center>
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</a>
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      </div>
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Latest revision as of 14:06, 6 November 2013

FIGHT TUBERCULOSIS WITH MODERN WEAPONS

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) that affects nearly two billion people around the world. On this website we present four new ways to use the power of synthetic biology in the fight against TB: from gene detection, to drug targeting, to infiltrating macrophages, to sabotaging the synthesis of proteins. Hover over these panels to see the project overview.

A biosensor that detects the presence of sequence specific antibiotic resistance genes.

A safe and specific high-throughput drug screening method that targets essential mycobacterial metabolic proteins.

A phage system with low fitness cost producing sRNA, which inhibits the synthesis of antibiotic resistance proteins.

Infiltrate macrophages with an E.coli producing TDMH, an enzyme that will lyse the Mycobacteria cell wall.
Detect
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Infiltrate
Sabotage
Jump to Results
TB Facts
TB in France
TB Gallery
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Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
+33 1 44 41 25 22/25
team2013@igem-paris.org
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