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Team:USTC CHINA
From 2013.igem.org
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<h2><a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/B.SubtilisCulture">Suicide mechanism of the reporter system</a></h2> | <h2><a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/B.SubtilisCulture">Suicide mechanism of the reporter system</a></h2> | ||
| - | <a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/B.SubtilisCulture"><img src=" | + | <a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/B.SubtilisCulture"><img src="https://static.igem.org/mediawiki/2013/4/48/2013ustc-china_Model1.png" width="310" height="180" /></a> |
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<h2><a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/ReporterSystem">The optimal culture conditions of Bacillus subtilis</a></h2> | <h2><a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/ReporterSystem">The optimal culture conditions of Bacillus subtilis</a></h2> | ||
| - | <a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/ReporterSystem"><img src=" | + | <a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/ReporterSystem"><img src="https://static.igem.org/mediawiki/2013/1/10/2013ustc-china_Model2.png" width="310" height="264" /></a> |
<h2><a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/MiceModeling"> | <h2><a href="https://2013.igem.org/Team:USTC_CHINA/Modeling/MiceModeling"> | ||
Mice Modeling</a></h2> | Mice Modeling</a></h2> | ||
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<h2><a href="https://2013.igem.org/Team:USTC_CHINA/HumanPractice/Communication" target="_blank"> | <h2><a href="https://2013.igem.org/Team:USTC_CHINA/HumanPractice/Communication" target="_blank"> | ||
Communication</a></h2> | Communication</a></h2> | ||
| - | <a href="https://2013.igem.org/Team:USTC_CHINA/HumanPractice/Communication" target="_blank"><img src=" | + | <a href="https://2013.igem.org/Team:USTC_CHINA/HumanPractice/Communication" target="_blank"><img src="https://static.igem.org/mediawiki/2013/5/5e/2013ustc-china_China-map.png" width="310" height="259" /></a> |
<h2><a href="https://2013.igem.org/Team:USTC_CHINA/HumanPractice/Communication" target="_blank"> | <h2><a href="https://2013.igem.org/Team:USTC_CHINA/HumanPractice/Communication" target="_blank"> | ||
Activity</a></h2> | Activity</a></h2> | ||
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<div class="sponsor" id="db"> | <div class="sponsor" id="db"> | ||
<p align="center">Deutsche Bank, China</p> | <p align="center">Deutsche Bank, China</p> | ||
| - | <div align="center"><a href="https://china.db.com/index_e.html" target="_blank"><img src=" | + | <div align="center"><a href="https://china.db.com/index_e.html" target="_blank"><img src="https://static.igem.org/mediawiki/2013/a/a7/2013ustc-china_Db-logo.png" alt="Deutsche Bank, China" height="65px" align="absmiddle" width="280px"></a> |
</div> | </div> | ||
</div> | </div> | ||
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<div class="sponsor"> | <div class="sponsor"> | ||
<p align="center">School of Life Sciences, USTC</p> | <p align="center">School of Life Sciences, USTC</p> | ||
| - | <div align="center"><a href="http://en.biox.ustc.edu.cn/" target="_blank"><img src=" | + | <div align="center"><a href="http://en.biox.ustc.edu.cn/" target="_blank"><img src="https://static.igem.org/mediawiki/2013/9/98/2013ustc-china_Life-logo.png" alt="School of Life Sciences, USTC" height="65px" align="absmiddle" width="280px"></a> |
</div> | </div> | ||
</div> | </div> | ||
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<div class="sponsor"> | <div class="sponsor"> | ||
<p align="center">USTC<span style="color:#fcc644">IF</span></p> | <p align="center">USTC<span style="color:#fcc644">IF</span></p> | ||
| - | <div align="center"><a href="http://www.ustcif.org/" target="_blank"><img src=" | + | <div align="center"><a href="http://www.ustcif.org/" target="_blank"><img src="https://static.igem.org/mediawiki/2013/3/3c/2013ustc-china_Ustcif-logo.png" height="65px" align="absmiddle" width="280px"></a> |
</div> | </div> | ||
</div> | </div> | ||
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<div class="sponsor"> | <div class="sponsor"> | ||
<p align="center">School of the Gifted Young, USTC</p> | <p align="center">School of the Gifted Young, USTC</p> | ||
| - | <div align="center"><a href="http://en.scgy.ustc.edu.cn/" target="_blank"><img src=" | + | <div align="center"><a href="http://en.scgy.ustc.edu.cn/" target="_blank"><img src="https://static.igem.org/mediawiki/2013/c/c1/2013ustc-china_Gifted_young.jpg" height="65px" align="absmiddle" width="280px"></a> |
</div> | </div> | ||
</div> | </div> | ||
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<div class="sponsor"> | <div class="sponsor"> | ||
<p align="center">School of physics, USTC</p> | <p align="center">School of physics, USTC</p> | ||
| - | <div align="center"><a href="http://en.physics.ustc.edu.cn/" target="_blank"><img src=" | + | <div align="center"><a href="http://en.physics.ustc.edu.cn/" target="_blank"><img src="https://static.igem.org/mediawiki/2013/6/68/2013ustc-china_Physics-logo.png" height="65px" align="absmiddle" width="280px"></a> |
</div> | </div> | ||
</div> | </div> | ||
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<div class="sponsor"> | <div class="sponsor"> | ||
<p align="center">Teaching Affairs Office of USTC</p> | <p align="center">Teaching Affairs Office of USTC</p> | ||
| - | <div align="center"><a href="http://www.teach.ustc.edu.cn/" target="_blank"><img src=" | + | <div align="center"><a href="http://www.teach.ustc.edu.cn/" target="_blank"><img src="https://static.igem.org/mediawiki/2013/f/f9/2013ustc-china_Teaching-logo.png" alt="Teaching Affairs Office Of USTC" style="background-color:white" height="65px" align="absmiddle" width="280px"></a> |
</div> | </div> | ||
</div> | </div> | ||
Revision as of 21:27, 21 September 2013
Why We Begin
we hope to provide a needle-free and non-skin-damage vaccination,
we hope everyone, even in the least developed area, could enjoy the benefit of medical progress.
more about project background
we hope everyone, even in the least developed area, could enjoy the benefit of medical progress.
more about project background
How We Design
With the support of TD-1, a special polypeptide, which can greatly facilitate macromolecule transdermal delivery through intact skin, we construct three different fuctional engineered bacillus subtilis; besides, we design a kill switch in the fouth type B.subtilis to ensure biosafety.
ANTIGEN
As the core of our in-situ system,
TD1-antigen expresser is designed
and will share a great percentage of
the total bacteria in our "band-aid".
more about project design
As the core of our in-situ system,
TD1-antigen expresser is designed
and will share a great percentage of
the total bacteria in our "band-aid".
more about project design
LTB
As one kind of our adjuvant expresser,
TD1-LTB is used to enhance the antigenicity.
For LTB has so many advantages, it's a wild using adjuvant for most of exsiting injected vaccine.
more about project design
As one kind of our adjuvant expresser,
TD1-LTB is used to enhance the antigenicity.
For LTB has so many advantages, it's a wild using adjuvant for most of exsiting injected vaccine.
more about project design
KNFα
It's worth mentioning that to improve the effects of
traditional vaccine, as another kind of our TD1-adjuvant expresser, KNFα bear the weight of our hope to increase the sensitivity of our immune system.
more about project design
It's worth mentioning that to improve the effects of
traditional vaccine, as another kind of our TD1-adjuvant expresser, KNFα bear the weight of our hope to increase the sensitivity of our immune system.
more about project design
REPORTER
Reporter, which notifies users whether the status of vaccine patch is all right and when they can stick the patches to arms . Further more killing switch is existed in them as a biosafety guard.
more about project design
Reporter, which notifies users whether the status of vaccine patch is all right and when they can stick the patches to arms . Further more killing switch is existed in them as a biosafety guard.
more about project design
What We've Achived
Molecules part
We took E.coli and the PET vector as the positive control and realized our ideas in the B.subtilis expression system based on PHT43 shuttle vector.
more about project results
We took E.coli and the PET vector as the positive control and realized our ideas in the B.subtilis expression system based on PHT43 shuttle vector.
more about project results
Protein part
Before we achieve fresh expression, we need first use purified protein to obtain exact data to verify our assumption.
more about project results
Before we achieve fresh expression, we need first use purified protein to obtain exact data to verify our assumption.
more about project results
Mice experiments
The most obvious character of our 2013USTC iGEM team is that we have not only achieved a series of molecule experiments but also tried mice experiments, which could be divided into transdermal experiments in vitro and animate mice experiments
more about project results
The most obvious character of our 2013USTC iGEM team is that we have not only achieved a series of molecule experiments but also tried mice experiments, which could be divided into transdermal experiments in vitro and animate mice experiments
more about project results
Thanks to the sponsors
Deutsche Bank, China
School of Life Sciences, USTC
USTCIF
School of the Gifted Young, USTC
School of physics, USTC
Teaching Affairs Office of USTC
