Team:Goettingen/Project

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===Navigation:===
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===Target: c-di-AMP===
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*<span style="color:#4a7ebb">Background</span>
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<p>Since the discovery of penicillin by Alexander Fleming in 1928, antibiotics have marked a major victory of mankind in the  battle against infectious diseases. However, after 90 years of abuse, the antibiotics are now losing their old time glory: Bacteria acquire resistance against antibiotics and become unbridled. </p>
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*[[Team:Goettingen/Project/OurProject|Our Project]]
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<p>We must control the use of antibiotics, meanwhile, we need new antibiotics, which can suffiently eliminate the invaders without hurting the "good" bacteria. Therefore, c-di-AMP, an important, recently discovered signaling molecule in gram-positive bacteria, has come to our sight.</p>
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**[[Team:Goettingen/Team/Reporters|Reporter Team]]
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<p>Out project is to build a screening system targeting c-di-AMP, which could be applied in novel-drug screening. With this system, the level of c-di-AMP in the cell can be visualised and measured. In the moment we are still wokring hard in the lab. To see our progress, please visit [[Team:Goettingen/NoteBook|Our Lab Book]].
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======Background======
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        <h3>The lack of novel antibiotics: the problem that we address </h3>
 
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        <p>The discovery of penicillin by Alexander Fleming in 1928 and the broad application of antibiotics marked a major victory of mankind in the  battle against infectious diseases. </p>
 
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<p> However, shortly after the beginning of industrial  penicillin  production in 1942 some human  pathogens  already acquired resistance against penicillin and related antibiotics. </p>
 
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<p>Moreover, the frequent use of antibiotics in the past and the rapid adaptation of bacteria to  these compounds  led to the development  of many multi-resistant pathogens.  </p>
 
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<p>Some of the pathogenic  bacteria  are even resistant  against most commercially available antibiotics.  Therefore, both the discovery and the development of new antibacterial substances  are extremely important to fight these threats of human health. Unfortunately, the pipeline of novel compounds with antibiotic activity  and appropriate pharmaceutical properties is  empty. This makes the challenge of finding  new compounds even more urgent!</p>
 
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<p> The first step in designing efficient novel antibacterial  compounds is the identification  of a suitable target. Very recently, a potentially interesting  target has been identified. The emerging signaling molecule cyclic dinucleotide c-di-AMP is essential in the Gram-positive model organism  B. subtilis  and in closely related pathogenic bacteria  such as Listeria monocytogenes, Streptococcus pneumoniae, and Staphylococcus aureus. </p>
 
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<p> These bacteria cause serious diseases and are often multi-resistant. c-di-AMP is needed for  the control  of  vital cellular processes in these pathogens because both: lack and accumulation of c-di-AMP, strongly inhibit growth of the bacteria. </p>
 
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<p> Therefore, any substance that disturbs  the homeostasis of the important signaling molecule c-di-AMP and the interaction with its  target is of substantial interest to fight human pathogens. The next important step in identifying  efficient antibacterial compounds, which either inhibit c-di-AMP biosynthesis or interfere  with the essential function of c-di-AMP  in the cell, is the development of a powerful screening system. </p>
 
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Revision as of 22:03, 26 June 2013

The beast and its Achilles heel:

 A novel target to fight multi-resistant pathogenic bacteria


Target: c-di-AMP

Since the discovery of penicillin by Alexander Fleming in 1928, antibiotics have marked a major victory of mankind in the battle against infectious diseases. However, after 90 years of abuse, the antibiotics are now losing their old time glory: Bacteria acquire resistance against antibiotics and become unbridled.

We must control the use of antibiotics, meanwhile, we need new antibiotics, which can suffiently eliminate the invaders without hurting the "good" bacteria. Therefore, c-di-AMP, an important, recently discovered signaling molecule in gram-positive bacteria, has come to our sight.

Out project is to build a screening system targeting c-di-AMP, which could be applied in novel-drug screening. With this system, the level of c-di-AMP in the cell can be visualised and measured. In the moment we are still wokring hard in the lab. To see our progress, please visit Our Lab Book.


Background

Array Team







DAC Team

Reporter Team







Parts

Retrieved from "http://2013.igem.org/Team:Goettingen/Project"