Team:IIT Madras

From 2013.igem.org

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{{:Team:IIT Madras/Templates/Header}}<html>
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      <div id="myCarousel" class="carousel slide">
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              <!--<h1>The Team</h1>
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              <p>Cras justo odio, dapibus ac facilisis in, egestas eget quam. Donec id elit non mi porta gravida at eget metus. Nullam id dolor id nibh ultricies vehicula ut id elit.</p>
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              <p><a class="btn btn-large btn-primary" href="#">More info</a></p>-->
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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
 
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You <strong>MUST</strong> have all of the pages listed in the menu below with the names specified. PLEASE keep all of your pages within your teams namespace. 
 
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{|align="justify"
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|You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing.
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|[[Image:IIT_Madras_logo.png|200px|right|frame]]
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|align="center"|[[Team:IIT_Madras | Team IIT_Madras]]
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<!--- The Mission, Experiments --->
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{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
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!align="center"|[[Team:IIT_Madras|Home]]
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!align="center"|[[Team:IIT_Madras/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2013&team_name=IIT_Madras Official Team Profile]
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!align="center"|[[Team:IIT_Madras/Project|Project]]
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          Shiga toxin, a worldwide menace, has killed over 1 million people to date and continues to afflict almost 150 million people each year. Currently, there is no treatment for Shiga toxicosis and it leads to complications in the human system like hemolytic uremic syndrome (HUS) and renal failure. Here, we propose a two-fold, novel synthetic biology approach to combat the lethal effect of the toxin. We aim to neutralize the already produced toxin through a nine amino acid Gb3 mimic peptide. We have engineered the Gb3 mimic along with a cellular export signal (ompF) downstream of AHL(quorum sensing molecule) inducible promoter (pLuxR). We also plan to prevent further toxin production by inhibiting the biofilm formation of shigatoxigenic E.coli using indole-3-acetaldehyde (I3A). We expect to validate our approach through functional assays and in silico modelling. Our findings can potentially initiate a new perspective of tackling Shiga toxicosis using synthetic biology tools.
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!align="center"|[[Team:IIT_Madras/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:IIT_Madras/Modeling|Modeling]]
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!align="center"|[[Team:IIT_Madras/Notebook|Notebook]]
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<img src="https://static.igem.org/mediawiki/2013/6/61/Iitm13_team_pic.JPG" width="100%" style="
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!align="center"|[[Team:IIT_Madras/Safety|Safety]]
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!align="center"|[[Team:IIT_Madras/Attributions|Attributions]]
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Latest revision as of 02:47, 28 September 2013

Indian Institute of Technology Madras
Shiga toxin, a worldwide menace, has killed over 1 million people to date and continues to afflict almost 150 million people each year. Currently, there is no treatment for Shiga toxicosis and it leads to complications in the human system like hemolytic uremic syndrome (HUS) and renal failure. Here, we propose a two-fold, novel synthetic biology approach to combat the lethal effect of the toxin. We aim to neutralize the already produced toxin through a nine amino acid Gb3 mimic peptide. We have engineered the Gb3 mimic along with a cellular export signal (ompF) downstream of AHL(quorum sensing molecule) inducible promoter (pLuxR). We also plan to prevent further toxin production by inhibiting the biofilm formation of shigatoxigenic E.coli using indole-3-acetaldehyde (I3A). We expect to validate our approach through functional assays and in silico modelling. Our findings can potentially initiate a new perspective of tackling Shiga toxicosis using synthetic biology tools.

Retrieved from "http://2013.igem.org/Team:IIT_Madras"